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INTRODUCTION: The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) and power to predict progression in large, multisite cohorts remains unclear. METHOD: Longitudinal demographics, T1-weighted magnetic resonance imaging (MRI), and cognitive scores of 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]-negative
At the core of this artistic research project is the idea that composing music can entail more than structuring sonic material; it may involve constructing the very space in which musical thoughts take shape. This space, the composable, is understood not as a fixed, pre-existing framework but as a space in flux—shaped by instruments, devices, spatial configurations, and performative gestures—where
Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genom
This case-study of pricing capability in the European packaging industry examines the process and mechanisms whereby pricing capability affects product market value appropriation. Pricing related challenges illustrated by the five cases included in the study ranged from keeping track of and setting consistent prices for up to 5000 different products spread across almost a thousand different custom
Members of the REST gene family characteristically have a transcription unit consisting of three exons. The first and the last exon are conserved among members, while the second exon--encoding almost all of the mature protein--differs considerably. The so far known REST genes are highly, and almost exclusively, expressed in the seminal vesicles. By sequence analysis we have now identified the gene
A series of comparative studies is suggested, focused on perceptions of outrigger canoes, and aimed at an increased understanding of the relationship between social relations, biodiversity, and sustainable development in Oceanic societies on small islands and in coastal areas undergoing rapid cultural change. After a critique of the recent notion that canoe-building in Polynesia developed as a res
