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Europe’s Beating Cancer Plan is a substantial European Union (EU) investment into cancer prevention and treatment. Integration of genetic services towards personalised cancer prevention and care is a flagship of this plan. Genetic counselling is critical to this integration, facilitating informed patient decision making and improved clinical management. However, growing demands for genetic testing
We explore mission assignment and task offloading in Open Radio Access Network (Open RAN)-enabled intelligent transportation systems (ITS), where autonomous vehicles utilize mobile edge computing for efficient processing. Existing studies often overlook mission dependencies and offloading costs, leading to suboptimal decisions. To address this, we formulate a novel optimization problem that integr
Background: Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods: We conducted GWA
Aims. We aim to refine the fundamental parameters of the TOI-2141 planetary system, which includes a transiting sub-Neptune orbiting a Sun-like star on a relatively long orbit of 18.26 days, by combining new photometric and spectroscopic observations. Methods. We analyzed new space-based photometry from TESS and CHEOPS, as well as 61 radial velocity measurements from HARPS-N. We performed individu
OBJECTIVE: It is unknown how risk factors for infection after transrectal prostate biopsy interact. We designed a study to evaluate this.METHODS: We identified biopsy procedures from 2006 to 2020 in the Swedish nationwide database PCBaSe. Primary outcome was post-biopsy infection, defined as a dispensed prescription of a urinary tract antibiotic and secondary outcome was inpatient care for infecti
Heat pumps are a key technology for decarbonizing residential heating, yet their diffusion remains limited in many countries, partly due to challenges of public acceptance and legitimacy. This study tracks how heat pumps are portrayed in German public discourse by analyzing sentiment in online news coverage. We compile a corpus of 33,131 German heat pump–related news articles published between 201
PurposeStreptococcus pyogenes is a cause of endometritis, a severe infection in women of reproductive age. S. pyogenes is classified into emm-types based on variations of the emm-gene. We aimed to compare the distribution of emm-types in endometritis to that of controls with bacteraemia, and to assess associations between emm-types and disease severity or clustering of cases.MethodsVaginal or cerv
The intrinsically disordered MYC proteins are master regulators of cellular growth and function, but when deregulated they become cancer drivers. MYC-protein interactions are key to oncogenesis, and while disrupting such interactions would be of significant therapeutic benefit, the intrinsically disordered properties of MYC have dramatically hampered their characterization. Here, we apply an integ
This paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplic
The efficiency and durability of Polymer Electrolyte Fuel Cells (PEFCs) depend on optimizing porous media components such as gas diffusion and catalyst layers. In parallel, the Lattice Boltzmann Method (LBM) has emerged as a powerful tool to model fluid flow, mass transport, and multiphase interactions in complex porous structures. This works provides a concise overview of recent advances in apply
The electrification of the transportation sector is a central strategy for decarbonization, yet it raises concerns about the capacity of existing electric power grids to meet increasing demand. This thesis investigates the interaction between large-scale electrified vehicle fleets and the electric power system under the assumption of full transport electrification. The focus is on assessing the re
Background: Policy advocacy (PA) in European healthcare has a strong tradition promoting evidence-based policies. Key organisations, including the European Observatory on Health Systems and Policies, the WHO’s Evidence-Informed Policy Network, and the OECD play pivotal roles in integrating research into policymaking. Objectives: To assess the involvement of European Family Medicine (FM) Associatio
The Circular Economy (CE) concept is widely promoted as a pathway to sustainability, yet its practical realization can appear to be challenging and unclear due to divergent definitions, interpretations and understanding about the implications and goals of a realized CE. Addressing this gap, this study develops the Circular Economy Loop Strategies (CELS) Framework, a synthesizing foundational model
With sea-level rise and increasingly frequent extreme weather events threatening communities, ecosystems and built infrastructure alike, climate change adaptation is pressing. This remains true in high-income countries where research capturing power dynamics underpinning adaptation continues to develop with implications for how policy and exclusion can be understood. Through a systematic review, t
Finding the optimal subset of individuals to observe in order to obtain the best estimate of the average opinion of a society is a crucial problem in a wide range of applications, including policy-making, strategic business decisions, and the analysis of sociological trends. We consider the opinion vector X to be updated according to a DeGroot opinion dynamical model with stubborn agents, subject
Strengthening international climate governance is seen as pivotal for advancing the Sustainable Development Goals (SDGs). However, a systematic understanding of their dynamic interactions remains limited. Given the strong interconnections among the SDGs, climate governance policies designed to advance one goal can significantly influence progress on others, highlighting the need for an integrated
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a growing clinical threat due to convergence of resistance and virulence determinants. We conducted a multicenter genomic epidemiology study analysing CR-hvKp isolates collected from 19 tertiary-care hospitals across Türkiye between 2018 and 2023. CR-hvKp isolates were subjected to whole-genome sequencing to investigate
Background: Inadequate postoperative pain management after lumbar discectomy may delay recovery, increase the risk of chronic pain, and prolong hospitalization. Effective analgesic strategies must balance pain control with minimal adverse effects. Objective: To identify the most effective postoperative analgesic interventions for patients undergoing lumbar discectomy. Databases and Data Treatment:
The article examines Europeanisation processes at the Spanish University of Valladolid (UVa) in the years around Spain’s adhesion to the European Communities in 1986. This event has often been seen as key to the Spanish transition to democracy, which had begun after the death of Francisco Franco in 1975. Drawing on a variety of source materials, the article shows that Europeanisation at the UVa in
