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We aimed at assessing familial risk of melanoma by considering a detailed family history of multiple primary (invasive/in situ) melanomas (MPM), stratified by histology and location.

To study frequency, possible baseline predictors, timing, and duration of sustained remission [SR; defined as 28-joint Disease Activity Score (DAS28) < 2.6 for at least 6 mos] in patients with established rheumatoid arthritis (RA) treated with different tumor necrosis factor (TNF) inhibitors [etanercept (ETN), infliximab (IFX), adalimumab (ADA)]. In addition, the aim was to compare (head-to-head)

Background No effective standard treatment exists for patients with radioiodine-refractory, advanced differentiated thyroid carcinoma. We aimed to assess efficacy and safety of vandetanib, a tyrosine kinase inhibitor of RET, VEGFR and EGFR signalling, in this setting. Methods In this randomised, double-blind, phase 2 trial, we enrolled adults (aged >= 18 years) with locally advanced or metastatic

The aim of the present study was to investigate the extent to which personality traits, after controlling for general intelligence, predict academic performance in different school subjects. Upper secondary school students in Sweden (N=315) completed the Wonderlic IQ test (Wonderlic, 1992) and the IPIP-NEO-PI test (Goldberg, 1999). A series of hierarchical structural equation models showed that ge

Airway hyperreactivity (AHR) is a major feature of asthmatic and inflammatory airways. Cigarette smoke exposure, and bacterial and viral infections are well-known environmental risk factors for AHR, but knowledge about the underlying molecular mechanisms on how these risk factors lead to the development of AHR is limited. Activation of intracellular mitogen-activated protein kinase (MAPK)/nuclear

Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing–proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (Tc

The objective of this paper is to provide a classification of recycling policy measures in relation to the actual recycling levels achieved in the EU Member States and in the European Environment Agency member countries. The paper covers the following five waste streams: packaging waste, waste electrical and electronic equipment (WEEE), municipal solid waste (MSW), biodegradable municipal waste (B

The morphological matrix is an important element of the engineering design methodology and is present in many textbooks. This method originally aimed at generating an exhaustive set of solutions for a given problem, by decomposing it into subproblems, finding solutions to each subproblem, and combining them. One issue associated with the morphological matrix has been the necessity to deal with the

Popular Abstract in Undetermined The thesis is written within the project Strengthening Legal Education in Vietnam.Well-known trademarks have been recognized as one of the most important types of trademark in the trademark system as reflected in both national law and in international treaties. The legal regime of well-known trademark protection has been continuously enhanced and developed over time due to the increasing importance of well-known trademarks becoming known to a worldwide public as well as develop

Gender scholarship has identified how paid care work reproduces male dominance and reinforces women's subordination, but also how labour and workplaces provide a critical space for women through the development of new forms of identity and struggle. In this ethnographic study of Swedish nurses' work, the concept of normative femininity is used in order to explore gender, labour, and changing relat