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Secreted proteins playa crucial role in intercellular communication during embryogenesis and in the adult. We recently described a novel method, designated as secretion cloning, that allows identifying extracellular proteins exclusively based on their ability to be secreted by transfected cells. In this paper, we present the results of a large-scale screening of more than 90,000 clones from three

Information and Communication Technologies (ICT) have relevant positive and negative impacts on environmental sustainability on various levels: First-order effects such as increasing electronic waste streams; second-order effects such as improved energy-efficiency of production; third-order effects such as a product-to-service shift in consumption or rebound effects in transport. In the simulation

Cytotoxic eosinophil granule proteins are considered important in the pathogenesis of allergic airway diseases such as rhinitis and asthma. To explore the cellular mechanisms behind eosinophil granule release in human allergic airways, 16 symptom-free patients with seasonal allergic rhinitis were challenged daily with allergen during 1 wk. Nasal lavage samples and biopsies, obtained before and 24

An initial-boundary value problem to a system of nonlinear partial differential equations, which consists of a hyperbolic and a parabolic part, is taken into consideration. The problem is discretised by a compact finite difference method. An approximation of the numerical solution is constructed, at which the difference scheme is linearised. Nonlinear convergence is proved using the stability of t

This paper is an attempt to understand how people, in the daily practice of interacting with material culture, created, dealt with and interpreted complex and socially stressful historical processes. A 16th-century timber-framed burgher house, the Reformation and industrialization are the focus of attention. Today the house stands in a museum of cultural history in the south Scandinavian town of L

Did the West - USA, UK, France and West-Germany - overthrow the Shah of Iran year 1979? Many Iranians believe so. Therefore the purpose of this thesis is to examine the role of the West in the Iranian revolution. The question which will be answered is: what are the motives that talk for respectively against the statement that the West overthrew the Shah of Iran? The method used is motive analyzes

The aim of this study is to offer a Lacanian psychoanalytic reading of some of the Danish philosopher/theologian Søren Kierkegaard's main writings. The thesis that I advance is that Kierkegaard is a subject of the lack, and that his writings are a modality of existentially handling this fundamental and constitutive lack. This is done, first, by showing what the concept "the subject of the

Title: Towards entering a new market: The role of Cooper’s stage-gate model in market knowledge absorption Date of the Seminar: 18.05.2016 Course: ENTN39 Corporate Entrepreneurship and Innovation Internship and Degree Project (Master’s thesis 15 ECTS) Authors: Tim Müller & Jukka Riitamäki Supervisor: Anna Brattström Keywords: stage-gate model, new product development, customer understandi

Climate change is an issue that can no longer be ignored and actions are taken all over the world in order to prevent the effects from becoming too severe. The energy system is transitioning towards more renewable energy sources and wind power has an important role in this development. The penetration of wind power in a lot of countries all over the world has increased rapidly during the last deca

At the Department of Orthopedics of University Hospital, Lund, Sweden, cancer incidence and overall and cause-specific mortality were studied in a prospective cohort of 677 women who had experienced a fracture of the distal forearm in 1974 or 1975. The women were followed through population-based population, cancer, and death registries in southern Sweden. There was a significant reduction In over

The main aims of this work were: 1) to increase the understanding of the segregation process that occurs during a segregation test that follows the ASTM sifting segregation procedure, and 2) to understand the effect of powder load, fines mass fraction and particle diameter ratio on the segregation of ideal blends. Binary blends of microcrystalline cellulose particles (mean diameter ranging from 16

Over the past 50 years, the concept existential question has played a less prominent role in upper secondary school curricula. The interpretation of the world view perspective has been retained until the curriculum 2000. Perspectives of personal development and interpretation of life in upper secondary school have almost disappeared. The syllabus has been content centred, reflective and analytical

Accurate detection and identification are essential components for epidemiological, ecological, and evolutionary surveys of avian haemosporidian parasites. Microscopy has been used for more than 100 years to detect and identify these parasites; however, this technique requires considerable training and high-level expertise. Several PCR methods with highly sensitive and specific detection capabilit

Studies showing that large-scale public health interventions in early life have lasting economic consequences are still scarce and rarely disclose the mechanisms. Being born in a hospital versus having a traditional birth attendant at home represents the most common early life policy change worldwide. Knowing the consequences of this policy is also important given the ongoing enlargement of matern

Steven Klepper's theory of industry clustering based on organizational reproduction and inheritance through spinoffs challenged the Marshallian view on industry clustering. This article provides an assessment of Klepper's theoretical and empirical work on industry clustering. We explore how "new" his spinoff theory on industry clustering was, and we investigate the impact of Klepper's theory on th