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Popular Abstract in Swedish Man har länge känt till att högt blodtryck {hypertoni}, bukfetma och sockersjuka {ålders diabetes} existerar samtidigt hos en och samma individ. Under de senaste decennierna har forskare försökt att hitta en gemensam mekanism till dessa tillstånd. Framför allt de senaste åren har man riktat uppmärksamheten mot det fett- och sockerreglerande hormonet insulin som tycks vaHypertensive individuals, even non-obese, have been shown to be resistant to the insulin-mediated glucose uptake in peripheral tissues {mainly skeletal muscle}. The aim of this study was to investigate hypothetical pathophysiological mechanisms for the development of hypertension with regard to insulin sensitivity in normotensive men with a family history of hypertension (RELs) as compared to men

Popular Abstract in Swedish Min avhandling består av sex delarbeten som redovisar olika undersökningar av ett värmestabilt enzym (xylanas). Detta enzym är isolerat från en bakterie (Rhodothermus marinus) som lever i varma källor (vid 55-77 °C) och enzymet förväntas alltså fungera vid dessa temperaturer. Enzymets uppgift i bakterien är att förse den med lagom långa kolhydratmolekyler som bakterien A gene encoding a multidomain xylanase from the thermophilic bacterium Rhodothermus marinus has been cloned, sequenced and produced in Escherichia coli . The gene product was found to be a 109 kDa protein consisting of five domains. The catalytic domain and the two polysaccharide binding domains (PBD, previously called carbohydrate binding domains) have been cloned and produced separately for func

A method for detection and genotyping of genital Chlamydia trachomatis infections based on omp1 gene amplification and sequencing was developed. DNA was extracted from urogenital or urine samples using a Chelex-based method, and an approximately 1,100-bp-long fragment from the omp1 gene was directly amplified and sequenced. Genotyping was performed by BLAST similarity search, and phylogenetic tree

Many studies have reported an increased incidence of inhibitors in previously untreated patients (PUPs) with severe haemophilia A after the introduction of recombinant products. It was the objective of this study to investigate whether the inhibitor incidence has increased between 1990 and 2009 in an unselected cohort of PUPs with severe haemophilia A (FVIII<1 %). Patients were consecutively recru

BACKGROUND: Oesophageal perforation is a rare but life-threatening condition with a significant morbidity and mortality. In this retrospective, nationwide study, the results of oesophageal perforation are reported for a well defined cohort, with special emphasis on the incidence, aetiology and results of surgical treatment.MATERIAL AND METHODS: 29 consecutive patients (16 males) were diagnosed wit

BACKGROUND: The aim of this work was to investigate the cortical and white matter changes that underlie cognitive impairment in patients with incident Parkinson's disease (PD) disease using voxel-based morphometry and diffusion tensor imaging.METHODS: Newly diagnosed nondemented PD (n = 125) and control subjects (n = 50) were recruited from the Incidence of Cognitive Impairment in Cohorts with Lon

A survey was made of the current status of treatment of haemophilic boys at 20 centres in 16 European countries and includes approximately 1500 of the estimated 6500 haemophiliacs in the participating countries. Many mild haemophiliacs are not seen, or seen infrequently, at haemophilia centres and this requires study. Nine of 18 centres provide continuous prophylaxis to 80-100% of their patients,

Popular Abstract in Swedish Moderna tillverkningsmaskiner är dyra och därför måste dess tillgänglighet och effektivitet ständigt hållas högt. Sådana resultat kan man inte åstadkomma utan tillämpning av en effektiv underhållsstrategi. Förutsättningar för att minska eller arrestera förslitnings hastighet på maskins delar och öka maskinlivslängden är stora vid användning av tillståndsövervakning, (TÖModern machinery is expensive and therefore must run at high availability and effectiveness which cannot be achieved without an effective maintenance policy. Condition monitoring, (CM), techniques can be utilised to reduce or arrest the rate of deterioration of a component so increasing operating life. The main result reported in this thesis is that the rolling element bearing’s mean effective li

A rare lethal autosomal recessive syndrome with skeletal dysplasia, polycystic kidneys and multiple malformations was first described by Gillessen-Kaesbach et al and subsequently by Nishimura et al. The skeletal features uniformly comprise a round pelvis, mesomelic shortening of the upper limbs and defective ossification of the cervical spine. We studied two unrelated families including three affe

Popular Abstract in Swedish Avhandlingens syfte är att ge ett bidrag till att belysa hur olika teorier och modeller kan förklara den sociala, kulturella och psykologiska situation som en avgränsad grupp kvinnor med narkotikaproblem befinner sig i. I avhandlingen görs en ansats att integrera ett socialpsykologiskt perspektiv med ett kvinnoforskningsperspektiv och ett personlighetspsykologiskt perspThe purpose of this study was to systematically examine the social, cultural and psychological situation of a group of women with drug addiction, and to gain an understanding of it. Different theoretical perspectives were utilized in efforts to understand and explain why some young women start using drugs. The attempt was made to integrate a social psychological perspective with a perspective base

Popular Abstract in English Forests have a positive impact on the level of greenhouse gases in the atmosphere because they absorb carbon dioxide through photosynthesis and store carbon in the soil. Moreover, many forests function as a sink for the greenhouse gas methane (CH4). The uptake of CH4 takes place in well-aerated soils through oxidation by methanotrophic bacteria. However, there is a net

Neural tissue transplantation has become an alternative treatment for Parkinson's disease (PD) and other neurodegenerative disorders. The clinical use of neural grafts as a source of dopamine for Parkinson's disease patients, although beneficial, is associated with logistical and ethical issues. Thus, alternative graft sources have been explored including polymer-encapsulated cells and nonneural c

The thesis aims to compare two approaches to psychosocial rehabilitation – day centres and clubhouses – and to explore if either appears better suited to support people in mental health recovery. The recovery focus is on opportunities for engaging in meaningful daily occupations, accessibility to social interaction and factors pertaining to perceived health and well-being. The thesis consists of f

Adaptation of crops to climate change has to be addressed locally due to the variability of soil, climate and the specific socio-economic settings influencing farm management decisions. Adaptation of rainfed cropping systems in the Mediterranean is especially challenging due to the projected decline in precipitation in the coming decades, which will increase the risk of droughts. Methods that can

I DEN DIVERSIFIERADE STADEN, hur kan vi planera och bygga platser för gemenskap som inte är beroende av social och kulturell likhet? I en tid då offentliga samtal förs kring segregation och utan-förskapsområden, aktualiseras frågor kring den fysiska miljöns betydelse för människors lika livsvillkor. I avsaknad av mer genomgripande lösningar kring boendesegregation har de offen-tliga rummen hamnat HOW CAN WE PLAN AND DESIGN FOR community in diverse urban situations? In response to segregation and social fragmentation, public space is increasingly being conceived of as a vehicle for fostering openness towards differences, both in planning practice and theory. Drawing on two recent public space projects – Superkilen in Copenhagen, Denmark, and Jubileumsparken in Gothenburg, Sweden – this thes

The ventral mesencephalon, containing the developing dopaminergic neurons of the substantia nigra-ventral tegmental region, was obtained from aborted human fetuses of 9-19 weeks of gestation. The tissue was grafted into the striatum of rats previously subjected to a 6-hydroxydopamine lesion of the mesostriatal dopamine pathway. The graft recipients were immunosuppressed by daily injections of Cycl

Aims To investigate the efficacy of sensor-augmented pump therapy vs. multiple daily injection therapy in patients with suboptimally controlled Type 1 diabetes. Methods In this investigator-initiated multi-centre trial (the Eurythmics Trial) in eight outpatient centres in Europe, we randomized 83 patients with Type 1 diabetes (40 women) currently treated with multiple daily injections, age 18-65 y

To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations.

Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women(1-4). A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified(5-9). We previously reported a susceptibility locus (SLEB2) for Nordic multi-case

Popular Abstract in Swedish Avhandlingen är en ny edition med en parallell engelsk översättning av åtta grekiska berättelser relaterade till ökenfadern Daniel från Sketis: 1) Abba Daniel från Sketis; 2) Abba Marcus, den helige dåren; 3) Den blinde mannen; 4AB) En helig och kysk ung kvinna; 5) Kvinnan som låtsades vara en drinkerska; 6) Eulogios Stenhuggaren; 7) Andronikos Penningväxlaren och hans This volume is a new edition with a parallel English translation of eight Greek stories related to Daniel of Sketis: 1) Abba Daniel from Sketis; 2) Abba Mark the Fool; 3) The blind man; 4AB) A holy and chaste young woman; 5) The woman who pretended to be a drunkard; 6) Eulogios the Stone-cutter; 7) Andronikos the Money-dealer and his wife Athanasia; 8) Anastasia Patrikia. The stories deal with se