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The PITX family of transcription factors regulate the development of many organs. Pitx1 mutants have a mild pituitary phenotype, but Pitx2 is necessary for the development of Rathke's pouch, expression of essential transcription factors in gonadotropes, and expansion of the Pit1 lineage. We report that lack of Pitx2 causes the pouch to undergo excessive cell death, resulting in severe pituitary hy

Aim: A correct diagnosis of coeliac disease, one of the most common chronic diseases in Swedish children, demands small bowel biopsy, which can be performed endoscopically or by means of a peroral capsule. Recently there was a debate among Swedish paediatric gastroenterologists, with some advocating the cessation of capsule biopsy in favour of endoscopic biopsies. To gain information on which to b

Several studies show that there are interactive processes between eutrophication and uptake of persistent organic pollutants (POPs) in aquatic biota. The main concept is that the increased biomass and production in aquatic ecosystems, due to excess discharge of nutrients, causes a chain event that results in reduced uptake of POPs in primary producers (phytoplankton). This effect is then transferr

This study describes the removal of polycyclic aromatic hydrocarbons (PAHs) from creosote oil contaminated soil by modified Fenton's reaction in laboratory-scale column experiments and subsequent aerobic biodegradation of PAHs by indigenous bacteria during incubation of the soil. The effect of hydrogen peroxide addition for 4 and 10 days and saturation of soil with H2O2 on was studied. In both exp

Mixtures of ethyl (hydroxyethyl)cellulose (EHEC) and sodium dodecanoate (SDoD) were investigated using surface tension, conductivity and transmittance measurements. The parameters of the surfactant to polymer association processes such as the critical aggregation concentration (cac) and saturation of the polymer by SDoD (psp) were determined from the plots of surface tension and specific conductiv

Exhaled nitric oxide is a potential marker of lower airway inflammation. Allergic rhinitis is associated with asthma and bronchial hyperresponsiveness. To determine whether or not nasal and exhaled NO concentrations are increased in allergic rhinitis and to assess the relation between hyperresponsiveness and exhaled NO, 46 rhinitic and 12 control subjects, all nonasthmatic nonsmokers without upper

Aims/hypothesis: We compared five surrogate insulin sensitivity ( IS) methods against the euglycaemic - hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL). Methods: We compared these IS methods against the clamp (0.28 nmol center dot min(-1) center dot m(-2) insulin infusion) M value in 147 women (

beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cor

https://www.keg.lu.se/sites/keg.lu.se/files/sgspl_utbildningsplan_2014-05-22.pdf - 2026-07-19

https://www.keg.lu.se/sites/keg.lu.se/files/sgspl_utbildningsplan_beslut_2017-02-02.pdf - 2026-07-19

In this paper, we determined the optimal flow rate trajectory during the loading phase of a mAb capture column. For this purpose, a multi-objective function was used, consisting of productivity and resin utilization. Several general types of trajectories were considered, and the optimal Pareto points were obtained for all of them. In particular, the presented trajectories include a constant-flow l

development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates.METHODS: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories

Traumatic brain injury (TBI) represents a significant risk factor for development of neurodegenerative diseases such as Alzheimer's and Parkinson's. The S100A9-driven amyloid-neuroinflammatory cascade occurring during primary and secondary TBI events can serve as a mechanistic link between TBI and Alzheimer's as demonstrated recently in the human brain tissues. Here by using immunohistochemistry i

The mitochondrial permeability transition pore is an inducer of cell death. During the reperfusion phase after cerebral ischemia, calcium accumulates in mitochondria, and a burst of free radical formation occurs, conditions that favor the activation of the mitochondrial permeability transition pore. Here the authors demonstrate that a blocker of the mitochondrial permeability transition pore, the

Dubbla tragedier – om att låta en litterär slitning förvandla ett dramatiskt skrivande Annika Nyman Huvudhandledare: Sven Bjerstedt Bihandledare: Maja Zade, Sofie Lebech Institution: Teaterhögskolan i Malmö 75%-seminarium, 18 mars 2022 Opponent: Laura Luise Schultz 1 1 Innehållsförteckning 1 Innehållsförteckning 2 2 Bakgrund, syfte och frågeställningar 6 2.1 Bakgrund 6 2.1.1 Peter Szondi och drama

https://www.thm.lu.se/sites/thm.lu.se/files/2022-03/Annika%20Nyman%2075%25-material.pdf - 2026-07-19