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Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the sing
Det finns ett myller av sammanflätade tilldragelser som man skulle kunna ta fasta på för att förstå uppkomsten av den globala rättviserörelsen. Det är fråga om ett myller som i och med demonstrationerna i Seattle, Prag, Göteborg, Genua och den globala fredsdemonstrationen den 15 februari 2003, de sociala världsforumen i Porto Alegre och Mumbai och ett otal andra aktiviteter inte går att förstå som
We report experimental measurements of high-order harmonic spectra generated in Ar using a carrier-envelope-offset (CEO) stabilized 12 fs, 800 nm laser field and a fraction (less than 10%) of its second harmonic. Additional spectral peaks are observed between the harmonic peaks, which are due to interferences between multiple pulses in the train. The position of these peaks varies with the CEO and
To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcino
Popular Abstract in Swedish Under senare år har de högsta domstolarna i Norden i ett antal uppmärksammade avgöranden åsidosatt lagar, som stått i strid med respektive lands grundlag eller med EKMR. En omdebatterad fråga är om domstolarna har gått för långt – eller om de har väntat för länge med att ta på sig denna uppgift. I denna bok sätts de nordiska domarnas uppgift att kritiskt granska lagarsIn recent years, the supreme courts in the Nordic countries have set aside statutes as contrary to the constitution of the country or to the ECHR. A much debated question is whether the courts have gone too far – or if they have waited too long to take on this task. In this dissertation, the task of Nordic judges to critically examine the compatibility of legislation with constitutional norms is
Popular Abstract in Swedish På de allra flesta arbetsplatser utsätts arbetstagarna för risker, och de kemiska hälsoriskerna utgör en omfattande del av dessa. Till exempel är det många som får astma orsakad av exponeringar i arbetsmiljön. En vanlig orsak till yrkesrelaterade luftvägsbesvär är exponering för isocyanater. Isocyanater är små reaktiva (instabila) ämnen som används i polymerindustrin föExposure to isocyanates may induce disorders in the airways of workers. Therefore, application, development and validation of methods for exposure assessment is of great importance. In the present study, we have determined the personal air and biomarker levels of isocyanates for a group of occupationally exposed workers (n=170) in different types of industrial processes. Also, the biomarker levels
Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis (RA) with both anti-citrullinated protein antibodies (ACPA) and auto-antibodies against the citrullinating enzyme, peptidylarginine deiminas
This study was aimed to optimize glucose level at different stages of buffalo in vitro embryo production procedure. Three glucose levels (1.5, 5.6 and 10 mm) along with a control (0 mm) were used at three phases of in vitro fertilisation (IVF) procedure viz. in vitro maturation (IVM), in vitro culture (IVC-I) (12-72 hpi) and IVC-II (72 hpi to 7 dpi). Maturation rate of oocytes was found different
The transition radiation tracker (TRT) is one of the three subsystems of the inner detector of the ATLAS experiment. It is designed to operate for 10 yr at the LHC, with integrated charges of /spl sim/10 C/cm of wire and radiation doses of about 10 Mrad and 2/spl times/10/sup 14/ neutrons/cm/sup 2/. These doses translate into unprecedented ionization currents and integrated charges for a large-sca
Continuous supermacroporous chromatographic columns with anion-exchange ligands [2-(dimethylanlino)ethyl group] and immobilized metal affinity (IMA) ligands (Cu2+-loaded iminodiacetic acid) have been developed allowing binding of Escherichia coli cells and the elution of bound cells with high recoveries. These poly(acrylamide)-based continuous supermacroporous columns have been produced by radical
Alkaline sphingomyelinase (alk-SMase) is a new member of the NPP (nucleotide pyrophophatase/phosphodiesterase) family that hydrolyses SM (sphingomyelin) to generate ceramide ill the intestinal tract. The enzyme may protect the intestinal mucosa front inflammation and tumorigenesis. PAF (platelet-activating factor) is a pro-inflammatory phospholipid involved in pathogenesis of inflammatory bowel di
The aim of this study was to explore participants' experiences and opinions about a free-choice system in relation to policy objectives articulated by the national government and local authorities. A case study was conducted. Thirty five informants participated. Qualitative interviews were undertaken. Results discussed are how to address different dimensions of choice, not only where, also what, b
Angiogenesis inhibition is an established treatment for several tumor types. Unfortunately, this therapy is associated with adverse effects, including hypertension and renal toxicity, referred to as "preeclampsia." Recently, we demonstrated in patients and in rats that the multitarget tyrosine kinase inhibitor sunitinib induces a rise in blood pressure (BP), renal dysfunction, and proteinuria asso
Congenic DRF.(f/f) rats are protected from type 1 diabetes (T1D) by 34 Mb of F344 DNA introgressed proximal to the Gimap5 lymphopenia gene. To dissect the genetic factor(s) that confer protection from T1D in the DRF.(f/f) rat line, DRF.(f/f) rats were crossed to inbred BBDR or DR.(lyp/lyp) rats to generate congenic sublines that were genotyped, monitored for T1D and positional candidate genes sequ
Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. Many antineoplastic drugs are classified as carcinogenic and teratogenic to humans. Cyclophosphamide (CP
he aim of this study was to explore aspects of the meaning of home as experienced by very old single-living people in Sweden. A grounded theory approach was used, and interviews were conducted with 40 men and women aged 80-89. The findings indicate that home has a central place in the lives of very old people because it is where they live and spend so much time. The significance of the home is bas
Examensarbetet har utförts på Höganäs AB där stor del av verksamheten drivs av ABB:s styrsystem. Eftersom ABB:s I/O-moduler har lång leveranstid för tillfället men också ett högt inköpspris så sökte företaget alternativ. Det skulle vara lönsamt att testa och analysera alternativ då priserna kan reduceras men också en nödlösning när I/O-moduler går sönder i verksamheten, eller när något nytt behöve
