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Co-elution effects can influence molar mass determination of large macromolecules with asymmetric flow field-flow fractionation coupled to multiangle light scattering

Starch and hence, amylopectin is an important biomacromolecule in both the human diet as well as in technical applications. Therefore, accurate and reliable analytical methods for its characterization are needed. A suitable method for analyzing macromolecules with ultra-high molar mass, branched structure and high polydispersity is asymmetric flow field-flow fractionation (AF4) in combination with

Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies

A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in

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This paper presents diagnostic criteria for Menière’s disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. The classification includes two

Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

Adenosine A(1) and A(2A) receptors are neuromodulatory systems that can control mnemonic behavior, which is modified by diabetes. Since the density of these adenosine receptors can change upon chronic noxious brain conditions, we now tested if the density of A(1) and A(2A) receptors was modified in the hippocampus of streptozotocin-induced diabetic rats. The binding density of the selective A(1) r

Effects of ultrasonic irradiation on the synthesis, crystallization, thermal and dissolution behaviour of chloride-intercalated, co-precipitated CaFe-layered double hydroxide

The output power (30–150 W) and the periodicity (20–100%) of ultrasound emission were varied in a wide range to regulate and improve the crystallization process in the commonly used co-precipitation technique of chloride-intercalated CaFe-layered double hydroxides. The influence of ultrasound irradiation on the as-prepared materials was studied by X-ray diffractometry, dynamic light scattering, UV

Investigation of Ultrafast Molecular Dynamics via Covariance Mapping : A Tool for Intense XUV Light Sources

The study of molecular dynamics involves observations of the motion of nuclei and electrons. While nuclear motion is usually on the picosecond or femtosecond timescale, attosecond precision is necessary to directly observe the motion of electrons. Ultrashort laser pulses have become established as a viable tool for probing femtosecond dynamics by irradiating the target for only extremely short tim

Impact of competitive foods in public schools on child nutrition : effects on adolescent obesity in the United States an integrative systematic literature review

Background: The United States (US) is currently facing a public health crisis due to the percentage of obesity in adolescents. The Center for Disease Control (CDC) stated the risks for children due to obesity are many. Adolescents obtain a large portion of their daily caloric intake at school; therefore, what foods/drinks they are consuming is so serious. Objective: To identify and analyze literat

Optimisation of occupational radiological protection in image-guided interventions : potential impact of dose rate measurements

The optimisation of occupational radiological protection is challenging and a variety of factors have to be considered. Physicians performing image-guided interventions are working in an environment with one of the highest radiation risk levels in healthcare. Appropriate knowledge about the radiation environment is a prerequisite for conducting the optimisation process. Information about the dose

Level of education and the risk of cancer in Sweden

It is well known that certain cancers have shown clusteringin educational and socioeconomic groups, but recent comprehensive data on clustering by education are limited. We determined standardized incidence ratios (SIRs), adjusted for several variables, for cancer among men and women in six educational groups based on the Swedish Family-Cancer Database. People were identified with a certain educat

Predictive risk mapping of human leptospirosis using support vector machine classification and multilayer perceptron neural network

Leptospirosis is a zoonotic disease found wherever human is in direct or indirect contact with contaminated water and environment. Considering the increasing number of cases of this disease in the northern part of Iran, identifying areas characterized by high disease incidence risk can help policy-makers develop strategies to prevent its further spread. This study presents an approach for generati

Long-term results from a phase II study of single agent paclitaxel (Taxol) in previously platinum treated patients with advanced ovarian cancer : the Nordic experience

BACKGROUND: Owing to the wide spread perception of a possible benefit from paclitaxel in the second-line situation the Nordic Gynecologic Oncology Group (NGOG) conducted two prospective phase II studies of paclitaxel single agent treatment (175 mg/m2, three-hour i.v. infusion with standard pre-medication every third week) in patients with relapsing or progressing epithelial ovarian cancer followin

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

African trypanosomes induce a generalized state of immunosuppression in their mammalian hosts. One characteristic of this is a suppression of lymphocyte responses to mitogen, which is mediated by suppressor macrophages. We investigated the involvement of nitric oxide in this phenomenon. Both peritoneal and splenic cell cultures from infected mice released nitrite and this was inhibitable by NG-mon

Exploring workplace related health resources from a salutogenic perspective: Results from a focus group study among healthcare workers in Sweden

Objective: The aim of this study was to explore healthcare workers' opinions on workplace related health resources relevant to promotion of their health. Participants: 16 registered nurses and 19 assistant nurses, from a medical emergency ward at a medium sized hospital in the south of Sweden, participated in the study. Methods: Eight focus group interviews were conducted, the material was con

Non-Legal Aspects of Legally Controlled Decision-Making. The failure of predictability in governing the 3G infrastructure development in Sweden

Predictability is a key function of law. When the application of law goes from being flexible to becoming unpredictable this key function is lost. This article shows how legal application can deviate from formal agreements and law, how legal predictability experiences a setback when other forces or values affect the decision making that is supposed to be strictly legally controlled. Non-legally ac

The impact of patient heterogeneity and socioeconomic factors on abatacept retention in rheumatoid arthritis across nine European countries.

There are substantial differences in accessibility to biological disease modifying antirheumatic drugs (bDMARDs) across countries. The objective of this study was to analyse the impact of patient demographics, disease characteristics and gross domestic product (GDP) on abatacept (ABA) retention in patients with rheumatoid arthritis (RA) treated in clinical practice.

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

FLT3 and c-KIT are crucial regulators of hematopoietic stem and progenitor cells. We investigated the role of STS1 and STS2 on FLT3 and c-KIT phosphorylation, activity, and function in normal and stress-induced hematopoiesis. STS1/STS2-deficient mice show a profound expansion of multipotent progenitor and lymphoid primed multipotent progenitor cells with elevated colony-forming capacity. Although

Lipoprotein binding to anionic biopolyelectrolytes and the effect of glucose on nanoplaque formation in arteriosclerosis and Alzheimer's disease.

Arteriosclerosis with its clinical sequelae (cardiac infarction, stroke, peripheral arterial occlusive disease) and vascular/Alzheimer dementia not only result in far more than half of all deaths but also represent dramatic economic problems. The reason is, among others, that diabetes mellitus is an independent risk factor for both disorders, and the number of diabetics strongly increases worldwid

Musculoskeletal Injury in Professional Dancers: Prevalence and Associated Factors: An International Cross-Sectional Study.

OBJECTIVE: The purpose of the study was to determine the prevalence and factors associated with injury in professional ballet and modern dancers, and assess if dancers are reporting their injuries and explore reasons for not reporting injuries. DESIGN: Cross-sectional study. SETTING: Participants were recruited from nine professional ballet and modern dance companies in Canada, Denmark, Israel,

Powered Mobility Devices in a Nordic Context: Service Delivery, Effectiveness and Methodological Development

This thesis has contributed to the methodological development in the field of assistive technology and has generated new knowledge about the effectiveness and the service delivery process when powered mobility devices are provided to adult first time users in a Nordic context. Some of the results have been used to investigate the relationship between the three key elements of Donabedian’s conceptu

Role of DARPP-32 in Breast Cancer Cell Signalling and Migration

Breast cancer is the most common form of cancer in women. While the prognosis for breast cancer patients without local or distal dissemination is relatively favorable, the prognosis is considerably worse once distal metastasis has been established. It is therefore imperative to identify molecular targets and develop novel anti-metastatic therapies that will stop, reduce or delay the spread and gro