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In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. In contrast, up-regulation of the ß-chain on these same

This article explores how the NT accounts of the rending of the veil in the Temple at the time of Jesus have been interpreted: as a sign of wrath, joy and grief.

The organisational network of global environmental governance (GEG) mirrors the complexity of the planet's manifold and overlapping ecosystems. Bursting onto the international stage in the 1970s, environmental issues began to be addressed by a series of new international organisations, most of them affiliated with the United Nations. Some of them, such as the United Nations Environment Programme (

Many studies identify energy efficiency as the most important and least costly option for reducing CO2-emissions while at the same time contributing to other policy objectives. The main challenge seems to be how to design, implement and evaluate policy to ensure that these opportunities are captured and policy perceived as legitimate. There is often a gap between rhetoric or broadly stated objecti

Introduction Opportunities for leisure activities and physical mobility are important for the ageing population. Therefore, we aim to describe leisure activities outside the home among very old (over 80 years of age) users and non-users of mobility devices in two European countries. Method Survey data on mobility device use, self-rated physical mobility and leisure activities outside the home were

2,2-Bis(hydroxymethyl)butyric acid (BHMB) is an important multifunctional chemical for the emerging bio-based polymer industry. It can be produced from trimethylolpropane (TMP) by selective oxidation using growing cells of Corynebacterium sp. ATCC 21245. However, this process is limited by the low volumetric productivity and low concentration of the final product. In the present study, we performe

The effect of primary vestibular disturbance on postural control was investigated in 11 normal subjects exposed to perturbation by bi-polar binaural galvanic stimulation of the vestibular nerve. The stimulus consisted of 30 s of sinusoidal galvanic stimulation at frequencies of 0.2, 0.3, 0.5, 1.0, 1.5, 2.0, 3.0 and 4.0 Hz, with a current of +/- 1 mA, the subject standing with open or closed eyes a

The development of new materials for solar-to-energy conversion should consider stability, ease of fabrication, and beneficial photophysical properties. In this context, a set of novel π-conjugated building blocks, with phospha- and arsaalkenes possessing a unique dithienyl annulated heterofulvenoid core, have been prepared as air- and moisture-stable sensitizers. These compounds unify electron-do

BACKGROUND: Maintaining and improving the quality of prosthetics and orthotics education at the Tanzania Training Centre for Orthopaedic Technologists is essential for the provision of appropriate prosthetics and orthotics services in African countries.OBJECTIVES: To describe how Tanzanian and Malawian graduates' of the Diploma in Orthopaedic Technology perceive their education and how it could be

Onshore wind turbines are becoming increasingly widespread globally, with the associated net effect that a greater number of people will be exposed to wind turbine noise (WTN). Sleep disturbance by WTN has been suggested to be of particular importance with regards to a potential impact on human health. Within the Wind Turbine Noise Effects on Sleep (WiTNES) project, we have experimentally investig

The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial

In a prospective study, resection of the thyroid gland by means of a linear stapling device was compared with the conventional resection technique in 12 consecutive patients with thyreotoxicosis. The median time for resection of the stapled lobe was shorter than for the conventionally resected right lobe, although the difference was not statistically significant. The median preoperative bleeding d

HYPOTHESIS: A variety of clinical and biochemical variables may be associated with hypocalcemia after surgery for parathyroid adenoma.DESIGN: A prospective study of patients who underwent surgery for solitary parathyroid adenoma.SETTING: A university hospital department of surgery.PATIENTS: Eighty-six consecutive patients who underwent surgery for solitary parathyroid adenoma.INTERVENTION: Parathy

Episodes of transient thyrotoxicosis after surgery for primary hyperparathyroidism have previously been described, and surgical trauma to the thyroid gland has been suggested as an etiologic factor. However, there are several links between the thyroid and parathyroid hormonal systems, and therefore other explanations are possible as well. In this study we investigate pre- and postoperative serum l