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Size and orientation of polar nanoregions characterized by PDF analysis and using a statistical model in a Bi(Mg1/2Ti1/2)O3-PbTiO3 ferroelectric re-entrant relaxor

Revealing the local structure information of relaxor ferroelectrics is necessary for a clear understanding of their structure-property relationships, especially the determination of the size of polar nanoregions (PNRs), which is still a long-standing challenge. In this work, the local structure of the pseudo-cubic solid solutions 0.60Bi(Mg1/2Ti1/2)O3-0.40PbTiO3 and 0.65Bi(Mg1/2Ti1/2)O3-0.35PbTiO3,

Association of glycemic control and chronic kidney disease with hospitalization in type 2 diabetes in a cross-sectional study in Region Halland

Aims: To examine the separate associations of glycemic control and chronic kidney disease with hospitalization days over one year in patients with type 2 diabetes (T2D). Materials and methods: A cross-sectional study using retrospective data on T2D patients in Region Halland, Sweden, during 2020. Data from the Region Halland database included hospitalizations, emergency visits, primary care encoun

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

The LKB1 tumour suppressor kinase phosphorylates and activates a number of protein kinases belonging to the AMP-activated protein kinase (AMPK) subfamily. We have used a modified tandem affinity purification strategy to identify proteins that interact with AMPKalpha, as well as the twelve AMPK-related kinases that are activated by LKB1. The AMPKbeta and AMPKgamma regulatory subunits were associate

Use of inhaled corticosteroids and bone mineral density in a population based study: the Nord-Trondelag Health Study (the HUNT Study)

Conflicting results have been reported of the long-term effects of treatment with inhaled corticosteroids (ICS) on bone. The objective of this study was to compare ICS users and non-users regarding bone mineral density (BMD) in a large population. A total of 65 225 adults participated in a cross-sectional study in the Nord-Trondelag Health Study 1995-1997. Those reporting asthma or asthma-related

"A Scrapbook of You + Me" : Intermediality and Bookish Nostalgia in J.J. Abrams and Doug Dorst's S.

Abstract på danska:Artiklen læser det eksperimentende bog-værk S. (2013), af Doug Dorst og J.J. Abrams, som en refleksion over, og et udtryk for den trykte romans forandrede status i en digital tidsalder. Som en eksperimenterende roman med gulnede sider og håndskrift i marginen synes S. at reflektere en materiel vending i literaturen. Den idealiserer bogmediet som et rum for materialitet og intimiThis article reads J. J. Abrams and Doug Dorst's S. (2013) as a reflection of the changing status and function of the printed novel in the digital age. As an experimental novel with yellowing pages and handwriting in the margins, S. appears to reflect a “material turn” in literature. It celebrates the book as a space of intimacy and memory, positioned in opposition to new digital media. However, t

Prevalence of obstructive lung diseases and respiratory symptoms in southern Sweden

The prevalence of obstructive lung diseases is increasing in Scandinavia and worldwide. The reasons for this are not known. The prevalence varies between countries but also between different areas within the same country. In northern Europe a north-south gradient and also an east-west gradient have been proposed. To our knowledge this is the first comprehensive epidemiological study concerning obs

A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX.

Trabecular bone score (TBS) is a grey-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images. TBS is a BMD-independent predictor of fracture risk. The objective of this meta-analysis was to determine whether TBS predicted fracture risk independently of FRAX probability and to examine their combined performance by adjusting the FRAX pr

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the bra

Hand injuries and cold sensitivity: Reliability and validity of cold sensitivity questionnaires.

Purpose. Sensitivity to cold is a common consequence of hand injuries and other conditions, and this phenomenon has a profound effect on health-related quality of life and upper-extremity disability. The aim of the present study was to examine the reliability and validity of the Swedish version of the Cold Sensitivity Severity (CSS) scale and Cold Intolerance Symptom Severity (CISS) questionnaire

Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B

We have designed and synthesized a new series of azapeptides which act as potential inhibitors of cathepsin B and/or cathepsin K. Their structures are based upon the inhibitory sites of natural cysteine protease inhibitors, cystatins. For the synthesized azapeptides, the equilibrium constants for dissociation of inhibitor-enzyme complex, K-i, were determined. Comparison of these values indicated t

Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy

Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11-duplications detected in about 2%–3% of all patients. Some genes are implicated like the LZTR1, ISL1, CELSR3, and the WNT3 genes, but most are not explained m

Agriculture for Economic Development in Africa Evidence from Ethiopia

The twenty-frst century has seen the concurrent rise of optimism about economic growth in sub-Saharan Africa and the return of the agricultural sector to the top of the development agenda. Ethiopia—with its rapid economic growth for two decades, achieved during a policy focus on the agricultural sector—is at the forefront of both these developments. This chapter introduces the book’s main theme of

The Sound of Interconnectivity; The European Vasculitis Society 2022 Report

The first European Vasculitis Society (EUVAS) meeting report was published in 2017. Herein, we report on developments in the past 5 years which were greatly influenced by the pandemic. The adaptability to engage virtually, at this critical time in society, embodies the importance of networks and underscores the role of global collaborations. We outline state-of-the-art webinar topics, updates on d

Is this time different? : Social capability and catch-up growth in Ethiopia, 1950–2020

This paper explores whether Ethiopia's rapid economic growth is transformative enough for the country to eventually catch up with high-income countries. It does so by exploring the change and continuity of four elements of social capability from 1950 to 2020: structural transformation, economic inclusion and the state's autonomy and accountability. It finds that Ethiopia's social capability modestThis paper explores whether Ethiopia's rapid economic growth is transformative enough for the country to eventually catch up with high-income countries. It does so by exploring the change and continuity of four elements of social capability from 1950 to 2020: structural transformation, economic inclusion and the state's autonomy and accountability. It finds that Ethiopia's social capability modest

Diversity mechanisms of MIMO antennas with six degrees-of-freedom

Abstract in Undetermined In this paper, we investigate the roles of different diversity mechanisms in two recently proposed six-port MIMO antennas using the effective degree-of-freedom concept. In particular, we confirm that angle and polarization diversities are indeed the dominant diversity mechanisms for the compact antenna that is designed to replicate the characteristics of the ideal co-locat

On parametric effects of wettability, surface roughness and porosity on nucleate pool boiling heat transfer

Phase-change heat transfer enhancement is of critical importance to meet high cooling demands. Recently, surface engineering (surface structuring) has emerged as a promising heat transfer enhancement method, especially with the development of nanotechnology. Surface parameters such as wettability, surface roughness and porosity are modified by surface engineering. This work aims to discuss the par