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BACKGROUND: Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population. The aim of this study was

Background: Despite high demand, mental health services in primary care in Ireland are underdeveloped. People with mild/moderate anxiety, depression and unspecified psychological distress are frequently seen in primary care settings, mostly by general practitioners (GPs). Occupational therapists have the potential to contribute to service-provision with interventions specially designed for the tar

Many bacteria can interfere with how antibodies bind to their surfaces. This bacterial antibody targeting makes it challenging to predict the immunological function of bacteria-associated antibodies. The M and M-like proteins of group A streptococci (GAS) exhibit IgGFc-binding regions, which they use to reverse IgG binding orientation depending on the host environment. Unraveling the mechanism beh

BACKGROUND: Residents struggle with advance care planning (ACP) discussions in the inpatient setting, and may not be aware of newer models for ACP that stress the importance of giving prognostic information and making a recommendation about cardiopulmonary resuscitation to patients and families.METHODS: A controlled study of a cognitive model for ACP embedded in a quality improvement (QI) project.

During WWII, the botanist Hylander (1943, 1949) studied the floristic composition of lawns in 249 landscape gardens mostly in Sweden and concluded that they all harboured multiple, but largely the same, non-native species and genotypes that had most likely been introduced together by the sowing of some im- ported grass seed mix. As demonstrated by the later additions by, for example, Ohlsén (1947)During WWII, the botanist Hylander (1943, 1949) studied the floristic composition of lawns in 249 landscape gardens mostly in Sweden and concluded that they all harboured multiple, but largely the same, non-native species and genotypes that had most likely been introduced together by the sowing of some im- ported grass seed mix. As demonstrated by the later additions by, for example, Ohlsén (1947)

Objectives: Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC. Materials and methods: ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (

Abnormal loading of the knee due to injuries or obesity is thought to contribute to the development of osteoarthritis (OA). Small animal models have been used for studying OA progression mechanisms. However, numerical models to study cartilage responses under dynamic loading in preclinical animal models have not been developed. Here we present a musculoskeletal finite element model of a rat knee j

Heart failure (HF) is a leading cause of death in both men and women. However, risk factors seem to differ for men and women and significant gaps in sex-specific knowledge exist. Mitochondria are critical for cardiomyocytes and in this study, we investigated the role of baseline mitochondrial DNA copy number (mtDNA-CN) in HF incidence in middle-aged women and its possible role in the association b

During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in Staphylococcus aureus. These enzymes are cofactors in ribosome assembly, where they cycle between the ON (GTP-bound) and OFF (GDP-bound) ribosome-associated

In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor

Recent Advances: Various studies have suggested that mitochondrial DNA copy number (mtDNA-CN), a surrogate biomarker of mitochondrial dysfunction, is an easily quantifiable biomarker for chronic diseases, including diabetes and cancer. However, current knowledge is limited, and the results are controversial. This has been attributed mainly to methodology and study design.Critical Issues: The incid

Background: The demographic shift is fast becoming a global challenge. Populations ageing rapidly is widely seen as one of the most powerful transformative forces affecting society over the next four decades.Due to the demographic challenge in most countries it is important to consider making working life sustainable. It is obvious that the main factor that distinguishes senior workers from other

Projektet är ett samarbete mellan LTH och åtta gymnasieskolor i närregionen som startade under hösten 2007 och går ut på att använda den s.k. SI-metodiken som komplement till den ordinarie undervisningen i naturvetenskapliga ämnen. SI-övningarna leds av teknologer från LTH. Syftet med projektet är flera: att förbättra samverkan mellan LTH och gymnasieskolor i närregionen; öka intresset för naturve

Evaluation of a complex healthcare intervention should include careful exploration of the mechanisms through which it brings about change. This paper describes a qualitative evaluation of the Redesigning Daily Occupations (ReDO®-10) programme as it was implemented for the first time with women with stress-related issues in a primary care setting in Ireland. The ReDO®-10 is a 10-week group interven

The atrioventricular (AV) node plays a central role during atrial fibrillation (AF).We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing the slower of the two AV nodal pathways, the refractory periods of the pathways, and the prolongation of refractory periods. All model parameters are

Uppsatsen undersöker den skönlitterära läsupplevelsen i applikationen Iceberg Reader för Iphone. Vid uppsatsens tillkomst var läsapplikationer för Iphone och Ipad något nylanserat i Sverige, och få läsare hade erfarenhet av läsning via denna plattform. Med hjälp av två kvalitativa undersökningar – en enkät, där nio personer deltog, och en fokusgruppsundersökning, där fem av de nio var med – har vi

Studiens syfte är att undersöka om vapenfokuseringseffekten påverkar det visuella minnet allena eller om den även påverkar det auditiva minnet. Ett teoretiskt resonemang förs även huruvida vapenfokuseringseffekten påverkar arbetsminnets system selektivt. Efter bekvämlighetsurval utfördes experiment där den ena gruppen (30 personer) fick se en film på ett rån (experimentgruppen) och den andra grupp