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Comparison of fatty acid profile in plasma phospholipids in women from Granada (southern Spain) and Malmo (southern Sweden)

We conducted a first pilot study on healthy women living in two countries with different dietary habits, Granada in the south of Spain and Malmo in the south of Sweden, in order to compare their levels of plasma phospholipid fatty acids, and to examine the relationship between the differences in food consumption. This study is part of a pilot study which is nested in the European Prospective Inves

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.

The 65-kDa glutamic acid decarboxylase (GAD65) autoantibodies (GAD65Abs), commonly found in type 1 diabetes mellitus (T1DM) patients, are also found at lower frequencies in type 2 diabetes mellitus (T2DM) patients. GAD65Abs in T1DM patients are epitope specific, in contrast to those found in other GAD65Ab-positive individuals, including T2DM patients. Our aim was to assess whether epitope-specific

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death

Induction of the mitochondrial permeability transition (MPT) has been implicated in cellular apoptosis and in ischemia-reperfusion injury. During MPT, a channel in the inner mitochondrial membrane, the mitochondrial megachannel, opens and causes isolated mitochondria to swell. MPT and mitochondrial swelling is inhibited by cyclosporin A (CsA), which may also inhibit apoptosis in some cells. Treatm

Migration, Transnationalism, and Social Change in Central Asia: Everyday Transnational Lives of Uzbek Migrants in Russia

There is an extensive research that explores the reproduction of transnational communities and relations, with a particular focus on locality, identity and culture. However, the existing literature on transnational migration is largely based on the case studies of immigrant communities living in the United States and Western Europe, while not much has been said about the transnational practices of

Surgical evaluation of a recombinant factorVIII prepared using a plasma/albumin-free method: Efficacy and safety of Advate in previously treated patients

Evaluation of factor F(V)III replacement in patients with haemophilia A undergoing surgery is critical for FVIII concentrates, yet large scale, multi-center prospective studies, particularly using continuous infusion, are generally lacking for new products. This study evaluated efficacy and safety of a newly developed recombinant FVIII (rAHF-PFM) administered by bolus or continuous infusion in hae

Applying the ASM3 model for evaluation of control strategies for a biological nitrogen removal wastewater treatment plant

Biological nutrient removal processes for municipal wastewaters have received quite some attention during the past decades, especially due to the introduction of stricter legislation with respect to allowable effluent pollutant discharge limits. The necessity for performance improvement of existing activated sludge wastewater treatment plants (ASWWTPs) has created a need for detailed process model

Burst detection and location in water transmission pipelines

This paper presents results from testing of a burst detection and location technique on a water transmission pipeline. The primary targets of the method are medium and large bursts that are the result of a sudden rupture of a pipe wall or other physical element in the pipeline system. The technique is based on the continuous monitoring of the pressure in the pipeline combined with a hydraulic tran

Neuropathy in female dental personnel exposed to high frequency vibrations

Objective-To evaluate early neuropathy in dental personnel exposed to high frequency vibrations. Methods-30 dentists and 30 dental hygienists who used low and high speed hand pieces and ultrasonic scalers were studied, and 30 dental assistants and 30 medical nurses not exposed to vibration (all women). Vibrotactile sensibility, strength, motor performance, sensorineural symptoms and signs, and vas

Cross-border regions in the Baltic Sea Area. Regionalisation and destination branding in tourism

This paper concerns tourism and destination branding. The aim of this study is to contribute to a discussion, within the field of tourism studies, considering the relationship between place-specific qualities of destinations and the development of destination profiles and destination brands. Interreg III A programmes within cross-border regions of the Baltic Sea Area are used as examples to highli

Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer

Inherited germline polymorphisms can cause gene expression levels in normal tissues to differ substantially between individuals. We present an analysis of the genetic architecture of normal adult skin from 470 genetically unique mice, demonstrating the effect of germline variants, skin tissue location, and perturbation by exogenous inflammation or tumorigenesis on gene signaling pathways. Gene net

Dopamine and Huntington's disease

Huntington's disease (HD) is an incurable, inherited, progressive neurodegenerative disorder that is defined by a combination of motor, cognitive and psychiatric features. Pre-clinical and clinical studies have demonstrated an important role for the dopamine (DA) system in HD with dopaminergic dysfunction at the level of both DA release and DA receptors. It is, therefore, not surprising that the d

On-line solid-phase extraction in liquid chromatography using restricted access pre-columns for the analysis of s-triazines in humic-containing waters

A coupled-column liquid chromatographic system using solid phase extraction pre-columns for the seven chlorotriazines, atrazine, desethylatrazine, desisopropylatrazine (DIA), propazine, simazine, desethylterbuthylazine and terbuthylazine, using photodiode-array detection (PDAD) was developed. Restricted access (RA), was investigated as a pre- column material, making use of non-adsorptive size excl

Nature of relaxation processes revealed by the action signals of intensity-modulated light fields

We present a generalized theory and experimental results of the action signals induced by the absorption of two photons from two phase-modulated laser beams. In our experiment, the phases of the laser beams are modulated at the frequencies φ1 and φ2, respectively. Their collinear combination leads to the modulation of the total intensity at the frequency φ=φ2-φ1. The action signals, such as photol

The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, α1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge

Background: The aim of this paper was to investigate the role of SLPI in patients with allergic rhinitis. From this point of view, we also examined leukocyte elastase, α1-antitrypsin, and albumin. SLPI is an inhibitor of serine proteases such as leukocyte elastase, cathepsin G, and mast-cell chymase. Since chymase is considered to participate in mast-cell degranulation and histamine release, SLPI

Bacterial vaginosis - Transmission, role in genital tract infection and pregnancy outcome: An enigma

Larsson PG, Bergstrom M. Forsum U, Jacobsson B, Strand A, Wolner-Hanssen P Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. APMIS 2005; 113:233-45. Whether bacterial vaginosis (BV) is acquired from an endogenous or an exogenous source is subject to controversy Despite findings of an association between sexual behaviour and BV some data indicate t