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A case of absent right aortic cusp causing serious aortic incompetence in a neonate is reported. A "bicuspidalization" repair broke down within 24 hours, but reoperation with annular enlargement and insertion of a 19-mm prosthetic valve resulted in complete recovery. This rare but life-threatening anomaly of the aortic valve can be recognized with Doppler echocardiography. Valve replacement in con

Ett landskapsperspektiv krävs för att effektivt bevara biologisk mångfald och gynna ekosystemtjänster, eftersom de bakomliggande ekologiska processerna sker på rumsliga skalor som är större än enskilda fält och gårdar. Genom att förstå dessa processer bidrar forskningsmiljön SAPES och associerade forskningsprojekt till att visa värdet av att lantbrukare samarbetar för att gemensamt gynna ekosystem

Urbanization has been very strong since the middle of the 1900s and from 2007, 50% of the population in the world has become urban. Today almost one third of this urban population, around 1 billion, is living in areas classified as slums with substandard housing and a lack of land rights. In some cases more than 50% of the growth of cities in developing countries has been implemented by the inform

Development of inhibitory antibodies to infused factor VIII (FVIII) concentrates continues to be the most serious complication of haemophilia A management. Induction of immune tolerance by administering high doses of FVIII concentrate (antigen) and prothrombin complex concentrates to control bleeding was originated in the 1970s in Bonn, Germany, by Dr Hans-Hermann Brackmann, and became known as th

Idiopathic pulmonary fibrosis is a fatal interstitial lung disease with limited therapeutic options. Current evidence suggests that IPF may be initiated by repeated epithelial injury in the distal lung followed by abnormal wound healing responses which occur due to intrinsic and extrinsic factors. Mechanisms contributing to chronic damage of the alveolar epithelium in IPF include dysregulated cell

Background: The role of non-group A streptococci and Fusobacterium necrophorum in pharyngotonsillitis has been disputed and few prospective studies have evaluated the effect of antibiotic treatment. This study uses registry data to investigate the relation between antibiotic prescription for pharyngotonsillitis in primary healthcare and return visits for pharyngotonsillitis, complications, and ton

Introduction: Monitoring replacement therapy with standard and extended half-life (EHL) products is challenging, since one-stage assay (OSA) and chromogenic substrate assay (CSA) results may differ significantly. Recent recommendations include local validation of each new product with recovery within 20–30%, depending on activity level. Aim: To validate factor VIII (FVIII) activity for monitoring

Många lantbrukare utför frivilliga åtgärder för att gynna miljön. Som kompensation för kostnader och inkomstbortfall får lantbrukarna en miljöersättning. Ersättningen är åtgärdsbaserad, vilket innebär att dess storlek beror på vilken typ av åtgärd det handlar om och dess omfattning. Denna studie undersöker effekten av att istället göra ersättningar resultatbaserade, det vill säga basera dem på hur

Diabetes impacts on brain metabolism, structure and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. However, it remains to be determined whether brain dysfunction induced by obesogenic diets results from permanent brain alterations. We tested the hy

AIM: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal.METHODS: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to co

Denne korte artikkelen tar for seg preverbale adverbialer, det vil si adverbialer som kan stå mellom det initiale leddet og det finitte verbet i setninger som i utgangspunktet skulle ha det finitte verbet på andre plass. Disse adverbialene modifiserer den proposisjonelle kjernen i utsagnet, noe som viser seg i at når et slikt adverbial står preverbalt, kan elementer som ikke inngår i den proposisjDenne korte artikkelen tar for seg preverbale adverbialer, det vil si adverbialer som kan stå mellom det initiale leddet og det finitte verbet i setninger som i ut-gangspunktet skulle ha det finitte verbet på andre plass. Disse adverbialene modifiserer den proposisjonelle kjernen i utsagnet, noe som viser seg i at når et slikt adverbial står preverbalt, kan elementer som ikke inngår i den proposi-

Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients fro

Listeners are constantly trying to predict what the speaker will say next. We concurrently measured the electrophysiological and haemodynamic correlates of syntactic pre-activation, investigating when and where the brain processes speech melody cues to upcoming word order structure. Pre-activation of syntactic structure was reflected in a left-lateralised pre-activation negativity (PrAN), which wa

At the catalytic site for the hydrolysis of cellulose the enzyme cellobiohydrolase Cel7A binds the enantiomers of the adrenergic beta-blocker propranolol with different selectivity. Methyl-to-hydroxymethyl group modifications of propranolol, which result in higher affinity and improved selectivity, were herein studied by 1H,1H and 1H,13C scalar spin–spin coupling constants as well as utilizing the

AIMS: The main objective was to determine premature stroke risk in men and women in Sweden with previous hospital admission for Type 1 diabetes or without previous hospital admission.METHODS: All individuals in Sweden aged 15-34 years at first hospital admission for Type 1 diabetes and aged 15-49 years at first hospital admission for stroke during the study period (1987-2001) were identified. Stan

Local adaptation is of fundamental interest to evolutionary biologists. Traditionally, local adaptation has been studied using reciprocal transplant experiments to quantify fitness differences between residents and immigrants in pairwise transplants between study populations. Previous studies have detected local adaptation in some cases, but others have shown lack of adaptation or even maladaptati

The gender-neutral third-person pronoun singular hen was recently introduced in Swedish as a complement to she (hon) and he (han). The initiative to add hen initially received strong criticism. In the present study, we analyzed 208 arguments from 168 participants with critical attitudes toward hen. We used Blaubergs’ (1980) and Parks and Roberton’s (1998) taxonomies of critical arguments against p