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Recent transport equity literature has proposed a sufficientarian approach to transport planning, according to which all individuals would be entitled to a minimum level of accessibility deemed adequate or sufficient. The implementation of this approach would require the adoption of an accessibility standard as a key performance indicator guiding transport investments, land use planning and servic

The research study focuses on the application of Soft Systems Methodology (SSM) to develop a collaborative user-centered approach within the context of organizational learning, and concludes with suggestions of further research. More specifically, it explores library users’ and academic librarians’ ideal characteristics for the library discovery and access services mediated through the Onl

When we develop general-purpose robot software components, we rarely know the full context that they will execute in. This limits our ability to make predictions, including our ability to detect program bugs early. Since running a robot is an expensive task, finding errors at runtime can prolong the debugging loop or even cause safety hazards. In this paper, we propose an approach to help develope

OBJECTIVE: To explore the experience of using audience response systems (ARS) in postgraduate physiotherapy training.DESIGN: Qualitative interview study following the 'reflexive thematic analysis' by Braun and Clarke.SETTING: Higher education university.PARTICIPANTS: Ten Italian students (60% men, N=6; 40% women, N=4) agreed to partake in the interviews.RESULTS: We generated four themes. Specifica

There has been much progress in the field of nanofluidics, and novel applications, such as single-cell analysis, have been achieved. In such cases, controlling the location of the gas/liquid interface is vital and partial hydrophobic modification is frequently used to pin the position of this interface. However, because the fluid manipulating pressure in such devices is comparable to the Laplace p

Commercial aviation systems are increasingly stretched to their capacity while existing Safety Management Systems (SMS) do not live up to our expectations as higher efficiency standards are taxing human resources, higher competition levels are reducing the potential for collaboration and the sharing of risk data, and technological advances are making systems difficult to operate and re-design. Avi

The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. The presentation relies on MHC class I (MHC-I) and MHC class II (MHC-II) molecules that are encoded by MHC-I and

In many contexts of multilingualism, language learners can initiate communication in the target language (TL), or a contact language (such as English). Patterns of use emerging from these choices vary between individuals and affect TL development. Willingness to communicate (WTC) needs to be investigated in ways that capture these variations. So far, WTC has not been studied in multilingual contex

Objectives Important gaps in previous research include a lack of studies on the association between socioeconomic characteristics of the workplace and coronary heart disease (CHD). We aimed to examine two contextual factors in association with individuals' risk of CHD: the mean educational level of all employees at each individual's workplace (education work) and the neighbourhood socioeconomic ch

Frost is damaging to plants when air temperature drops below their tolerance threshold. The set of mechanisms used by cold-tolerant plants to withstand freezing is called “hardening” and typically take place in autumn to protect against winter damage. The recent incorporation of a hardening scheme in the demographic vegetation model FATES opens up the possibility to investigate frost mortality to

Smart contracts are programs with data (mutable state); stored on and executed by blockchain platforms. The transactions (or function invocations) dispatched to smart contracts often change their state. In the Ethereum blockchain, nodes (aka miners/validators) can schedule a set of transactions in any order in a block. Multiple transactions in a single block operating on a contract's shared state

PURPOSE: Invasive lobular carcinoma (ILC) is a subtype of breast cancer accounting for 10% of breast tumors. The majority of patients are treated with endocrine therapy; however, endocrine resistance is common in estrogen receptor-positive breast cancer and new therapeutic strategies are needed. Bromodomain and extraterminal inhibitors (BETi) are effective in diverse types of breast cancer but the

Methylglyoxal (MG) is a reactive and toxic compound produced in carbohydrate, lipid, and amino acid metabolism. The glyoxalase system is the main detoxifying route for MG and consists of two enzymes, glyoxalase I (GlxI) and glyoxalase II (GlxII). GlxI catalyzes the formation of S-d-lactoylglutathione from hemithioacetal, and GlxII converts this intermediate to d-lactate. A relationship between the

Calls for research contribution and demands for original theories have become visibly and audibly louder in review processes over the last two decades. In interpretivist marketing and consumer research, such calls have been accompanied by an emphasis on the importance of theory and on drawing on context when crafting impactful research contributions. By investigating the rhetorical claims made by

Ball-rolling dung beetles are known to integrate multiple cues in order to facilitate their straight-line orientation behaviour. Recent work has suggested that orientation cues are integrated according to a vector sum, that is, compass cues are represented by vectors and summed to give a combined orientation estimate. Further, cue weight (vector magnitude) appears to be set according to cue reliab

Context:Bug reports created during software development and maintenance do not always describe deviations from a system’s valid behavior. Such invalid bug reports may consume significant resources and adversely affect the prioritization and resolution of valid bug reports. There is a need to identify preventive actions to reduce the inflow of invalid bug reports. Existing research has shown that m