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We evaluated the effect of anticholinergic burden on 219 participants with incident Parkinson's disease (PD) and 99 controls at study baseline and 18 months. Anticholinergic burden for each individual was calculated and summed according to the Anticholinergic Drug Scale (ADS). Medication with anticholinergic activity was more commonly prescribed in PD compared to controls, although mean ADS scores
Soil carbon (C) and nitrogen (N) availability depend on the breakdown of soil polymers such as lignin, chitin, and protein that represent the major fraction of soil C and N but are too large for immediate uptake by plants and microorganisms. Microorganisms may adjust the production of enzymes targeting different polymers to optimize the balance between C and N availability and demand, and for inst
Vulture populations worldwide have suffered precipitous declines in recent decades. The Cinereous Vulture Aegypius monachus, a highly philopatric scavenger distributed across southern Europe and the central Asian plateau, is threatened in many parts of its range. Turkey holds the second largest population of this species in the Western Palaearctic, but there has been no research on its genetic str
OBJECTIVE: Determine prevalence and associations with pulmonary hypertension (PH) in preterm infants.STUDY DESIGN: Prospective institutional echocardiographic PH screening at 36 to 38 weeks' corrected gestational age (GA) for infants born <32 weeks' GA who had bronchopulmonary dysplasia (BPD; group BPD), and infants without BPD who had a birth weight (BW) <750 g, or clinical suspicion for PH (grou
In A Transnational History of the Australian Animal Movement, Gonzalo Villanueva covers the important events that led to the addition of an entirely new issue to the political agenda, transforming the conditions of nonhuman animals into a matter of public concern. Grounded in transnational history, social movement studies, and the emerging field of critical animal studies, A Transnational History
Deepened knowledge on response of biota and ecological processes following fire is essential for a future with warmer climate and more disturbances. In 2014 the first mega-fire (13,100 ha) for at least a century in Scandinavia hit south-central Sweden, in a production forest landscape shaped by clearcutting forestry. Ecological dynamics is followed in >20 projects from universities, authorities an
The generated magnitude of quadrature squeezing in a cavity-coupled ensemble, which is continuously driven using a coherent off-axis field, is theoretically explored. Using a truncated set of equations of motion derived from a Dicke Hamiltonian, steady-state quadrature squeezing of the cavity field is numerically calculated to approach a limit of -3dB, while frequency-modulated quadrature squeezin
Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precision
A large fraction of nitrogen (N) in forest soils is present in mineral-associated proteinaceous compounds. The strong association between proteins and minerals limits microbial accessibility to this source, which is a relatively stable reservoir of soil N. We have shown that the ectomycorrhizal (ECM) fungus Paxillus involutus can acquire N from iron oxide-associated proteins. Using tightly control
Improving our understanding of the relationships between biodiversity and the delivery of ecosystem services is crucial for the development of sustainable agriculture. We introduce a novel framework that is based on the identification of indicator species for single or multiple ecosystem services across taxonomic groups based on indicator species analyses. We utilize multi-species community data (
Hybridization is increasingly recognized as a potent evolutionary force. Although additive genetic variation and novel combinations of parental genes theoretically increase the potential for hybrid species to adapt, few empirical studies have investigated the adaptive potential within a hybrid species. Here, we address whether genomic contingencies, adaptation to climate, or diet best explain dive
Towards a Cultural Politics of Climate Change provides a new perspective on how climate change matters in policy-making, business and everyday life. It argues that the work of low carbon transitions takes place through the creation of devices, the mobilisation of desires, and the articulation of dissent. Using case studies from the US, Australia, and Europe, the book examines the creation and cont
Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, whic
Both research and policy recognize land systems as fundamental to human life and activities. However, these two perspectives approach land from different ends and it can be difficult to see how studied variables contribute to broader policy goals. In this paper, we argue that there is a need to better select variables to study land systems as social-ecological systems, and to align research more w
Offspring size is a key functional trait that can affect all phases of the life history, from birth to reproduction, and is common to all the Metazoa. Despite its ubiquity, reviews of this trait tend to be taxon-specific. We explored the causes and consequences of offspring size variation across plants, invertebrates and vertebrates. We find that offspring size shows clear latitudinal patterns amo
Applying media analysis, this article addresses how the exclusion of Muslim women from fields of common public interest in Sweden, such as partaking as an active citizen, is materialized. Focusing on a specific event—the cancellation of a screening of Burka Songs 2.0—and the media coverage and representation of the cancellation, it discusses the role of discourses of gender equality, secularity an
