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Laminins are heterotrimeric glycoproteins of the basement membranes. Laminin 1 (alpha 1, beta 1, gamma 1) is the major laminin expressed during early mouse embryogenesis. To gain access, to the physiological function of laminin alpha 1 chain, we developed a conditionally null allele of its encoding gene (Lama1) using the cre/loxP system. Floxed-allele-carrying mice (Lama1(flox/flox)) display no ov

Detecting danger is one of the foremost tasks for a neural system. Larval parasitoids constitute clear danger to Drosophila, as up to 80% of fly larvae become parasitized in nature. We show that Drosophila melanogaster larvae and adults avoid sites smelling of the main parasitoid enemies, Leptopilina wasps. This avoidance is mediated via a highly specific olfactory sensory neuron (OSN) type. While

Conversation published in Europanic, a publication documenting the history and development of Europan in Sweden. The conversation reflects on the author’s experience through five awarded editions of the Europan competition in Spain, Norway and Sweden. Europan is a biennial European competition and platform for architecture, housing and urban development involving multiple European countries and mu

In this paper we investigate the performance of Nordic hedge funds in terms of their ability to earn abnormal returns during the period 2003-2011. We further test for the presence of short-term persistence during the period of disturbed market conditions. The single-index and four-factor models are used in order to estimate the traditional performance measures for individual funds as well as for p

An indication of the problematic consent in a private relationship was given by judge Pettiti in his concurring opinion in Laskey, Jaggard and Brown v. The United Kingdom. The applicants were accused and convicted for sado-masochistic acts on themselves and on other, consenting people in private. One of the applicants' claim was that those acts were conducted by willing adult participants. The

A study of diurnal variations in methane flux in a fen in Kobbefjord in Southwest Greenland is presented. Four separate periods, each of one week, from the growing seasons of 2009 and 2010 were chosen. Methane flux data were compared to surface temperature, soil temperature and photosynthetically active radiation (PAR). Regression tests between surface temperature and methane flux produced highly

Air pollution is a global health problem and in Mozambique, indoor air pollution is primarily caused by cooking over an open fire. This study examines the potential of coconut charcoal as a cleaner cooking fuel and as a possible source of income for women in the village of Linga Linga, Mozambique. Previous research conducted in the village identified a need to investigate the willingness of the co

The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in human

BACKGROUND: Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles in key cellular processes. N-BLR is a primate-specific long non-coding RNA that modulates the epithelial-to-mesenchymal transition, facilitates cell migration, and increases colorectal cancer invasion.RESULTS: We performed multivariate analyses of data from t

OBJECTIVE:: To compare the effects of ST-waveform analysis in combination with cardiotocography with conventional cardiotocography for intrapartum fetal monitoring. DATA SOURCES:: We searched MEDLINE, Embase, and PubMed for randomized controlled trials (RCTs) evaluating ST-waveform analysis for intrapartum fetal monitoring. METHODS OF STUDY SELECTION:: We identified RCTs that compared ST-waveform

Aims The aims were to (i) investigate initial construct validity of a tool for assessment of time allocation in occupational balance, and (ii) describe perceived occupational balance and its relationship with socio-demographics, well-being, and personal recovery among people with mental illness. Methods Satisfaction with Daily Occupations and Occupational Balance (SDO-OB) was administered to 226 p

Hassles and uplifts, a concept used in measuring daily stress events, was applied to working mothers' everyday life. The aim was to explore the stability in working mothers' experiences in patterns of daily occupations, operationalized as hassles and uplifts, between the year 2000 (baseline) and the year 2005 (follow-up). Further, the intention was to reveal possible differences in the number, ori

We have studied the oxidation of CO over Rh(100) using high pressure x-ray photoelectron spectroscopy under CO and O2 pressures ranging from 0.01 to 1 mbar. The results show a very low or no conversion for the CO covered surface found at low temperatures, while the activity rises slightly when the temperature is high enough for some CO to desorb, exposing surface sites for dissociative O2 adsorpti

Popular Abstract in Swedish Energiförsörjning är essentiellt för alla samhällen världen över, men jordens resurser är inte obegränsade. Växter utgör en stor källa av förnyelsebara råvaror som skulle kunna användas för att ersätta en del fossila energikällor och material. I växters cellväggar finns olika typer socker som sitter ihop i kedjor av så kallade polysackarider. Cellulosa är den mest kändaβ-Mannoside hydrolases are enzymes that are involved in conversion of the major soft-wood hemicellulose O-acetyl-galactoglucomannan, an important renewable biomass resource. They belong to clan A of glycoside hydrolases and share a common (β/α)8-TIM barrel fold. For their catalysis, they use a two-step retaining double displacement mechanism, and may in addition to hydrolysis also perform transgly

When liquid packaging board is made aseptic in the filling machine, the unsealed edges of the board are exposed to hydrogen peroxide. A high level of liquid penetration may lead to aesthetic as well as functional defects. The ability to make a priori predictions about the edge wicking properties of a certain paperboard material is therefore of great interest to the paper industry, as well as to pa

Invasive species can displace natives, and thus identifying the traits that make aliens successful is crucial for predicting and preventing biodiversity loss. Pathogens may play an important role in the invasive process, facilitating colonization of their hosts in new continents and islands. According to the Novel Weapon Hypothesis, colonizers may out-compete local native species by bringing with