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Background: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (

We investigate whether it is possible that viable microbes could have been transported to the Earth from planets in extra-solar systems by means of natural vehicles such as ejecta expelled by comets or asteroid impacts on such planets. The probabilities of close encounters with other solar systems are taken into account as well as the limitations of bacterial survival times inside ejecta in space,

The primary goal of this study was to examine whether changes in the temporal distance of a moral dilemma affect how it is perceived and subsequently resolved. Based on Construal Level Theory (Trope & Liberman, 2003), it was predicted that the relative weight of abstract justice features should increase and the relative weight of concrete care features should decrease with temporal distance. T

Evidence-based knowledge of how to guide the mothers of preterm infants in breastfeeding establishment is contradictive or sparse. The aim was to investigate the associations between pre-specified clinical practices for facilitating breastfeeding, and exclusive breastfeeding at discharge as well as adequate duration thereof.

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Ungefär var tionde kvinna beräknas drabbas av bröstcancer, och i Sverige insjuknar ungefär 7.000 kvinnor årligen. Glädjande nog har överlevnaden förbättrats och nästan 90% lever 5 år efter sin diagnos och cirka två tredjedelar kan anses botade. Trots detta dör cirka 1.500 kvinnor i sjukdomen i Sverige vBreast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. The heterogeneity of breast tumours is reflected in the identification of at least five molecular subtypes named basal-like, luminal A, luminal B, HER2-enriched and normal-like, which are believed to originate from different cell typ

Performance improvements are always needed in computer graphics. Better performance frees up computational resources which can be used to increase the level of realism in the rendered images. Despite a very rapid development of graphics hardware, we are still far from the point where photo-realistic rendering can be done in real time. Therefore, better algorithms must be developed in order to adva

Syftet med rapporten har varit att analysera erfarenheterna av miljöanpassad upphandling och innovationsupphandling, samt hur dessa styrmdel kan bidra till uppfyllandet av olika politiska målsättningar. Rapporten redogör bl.a. för målsättningarna för upphandling, betydelsen av en efterfrågedriven innovationspolitik, samt hur upphandling kan samverka med andra styrmedel på miljöområdet.

Objective To estimate the diagnostic accuracy and interobserver agreement in predicting intracavitary uterine pathology at offline analysis of three-dimensional (3D) ultrasound volumes of the uterus. Methods 3D volumes (unenhanced ultrasound and gel infusion sonography with and without power Doppler, i.e. four volumes per patient) of 75 women presenting with abnormal uterine bleeding at a bleeding

Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants becaus

The ATLAS Collaboration measures the inclusive production of Z bosons via their decays into electron and muon pairs in p + Pb collisions at root S-NN = 5.02 TeV at the Large Hadron Collider. The measurements are made using data corresponding to integrated luminosities of 29.4 and 28.1 nb(-1) for Z -> ee and Z -> mu mu, respectively. The results from the two channels are consistent and combined to

Potential applications of grating-based X-ray phase-contrast imaging are investigated in various fields due to its compatibility with laboratory X-ray sources. So far the method was mainly restricted to X-ray energies below 40 keV, which is too low to examine dense or thick objects, but a routine operation at higher energies is on the brink of realisation. In this study, imaging results obtained a

This article outlines a potential synergy between sustainability and well-being research. Currently aims within well-being and sustainability research focus on increasing well-being. First, sustainability is defined and important concepts within it highlighted, that is, aims, interdependencies, constraints, values and balanced adaptive processes. It is suggested that positioning well-being more cl

Since its publication in 1962, Mats P. Malmer’s book Jungneolithische Studien has heavily influenced subsequent work on the Swedish-Norwegian Battle Axe Culture. Malmer characterized burial customs as strictly regulated and conservative. Recent archaeological activity in the province of Scania, southern Sweden, provides us with an augmented empirical basis for testing Malmer’s conclusions. In addi

Background: Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhibit a similar spatial encoding of sensory input to NWR as previously found in t

Characterization of the glomerular filtration barrier is of fundamental importance for understanding the pathophysiology of proteinuric kidney diseases. Furthermore, it can be of key value in the understanding of microalbuminuria, which is often associated with endothelial dysfunction in conjunction with cardiovascular disease. In the four studies of this doctoral thesis, macromolecular probes hav

Background: Treatment of pediatric T-cell acute lymphoblastic leukemia (T-ALL) has improved, but there is a considerable fraction of patients experiencing a poor outcome. There is a need for better prognostic markers and aberrant DNA methylation is a candidate in other malignancies, but its potential prognostic significance in T-ALL is hitherto undecided. Design and Methods: Genome wide promoter D