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Lumican and fibromodulin compete for collagen type I binding in vitro and fibromodulin-deficient mice have four-fold more lumican in tendons. These observations indicate that homologous sequences in lumican and fibromodulin bind to collagen type I. Here, we demonstrate that lumican binding to collagen type I is mediated mainly by Asp-213 in LRR 7. The mutation D213N in lumican impairs interaction
Individuals are often restricted to indirect cues when assessing the mate value of a potential partner. Females of some species have been shown to copy each other’s choice; in other words, the probability of a female choosing a particular male increases if he has already been chosen by other females. Recently it has been suggested that mate-choice copying could be an important aspect of human mate
Phospholipase C-gamma (PLC-gamma) isoforms are thought to be activated by both tyrosine phosphorylation and phosphatidylinositol 3,4,5 trisphosphate (PtdIns 3,4,5 P(3)), the product of phosphatidylinositol 3-kinase (PtdIns 3-kinase). In this study, we show that stimulation of mouse macrophages with either zymosan beads or bacteria (Prevotella intermedia) induced tyrosine phosphorylation of PLC-gam
The optimal definition of the size, shape and location of gross tumour volume is one of the most important steps in the planning of radiation therapy, and necessitates a proper understanding of the procedure from both the oncologic radiologist and the radiation oncologist. This overview reports on the different terms and concepts that have been recommended in the ICRU Reports for this purpose; the
Here, the problem of the classical chaos effect on dissipation in nuclear many-body systems is addressed. To investigate this problem, the energy response on parametric driving of external confinement of the simplest interacting many-body system is studied: two identical like-charged particles moving on the plane in the field of a deformed harmonic oscillator, which shows a rich structure of the c
This study evaluated the structural reliability, construct-related validity, and cultural validity generalization of the Hare Psychopathy Checklist: Screening Version (PCL:SV) in a sample of more than 560 male and female Swedish forensic psychiatric treatment patients, forensic evaluation patients, and criminal offenders. Structural reliability was excellent for most indices. PCL:SV scores were hi
Motivating people is an importnt issue for physiotherapists working with health promotion aiming at maintaining and strengthening resources for health.The aim of this literature review is to describe the theoretical foundations for how to improve work motivation and from that suggest strategies that can be used by physiotherapists in health promotion. The databases Medline and Psychlit were search
One way to assess the uncertainty in fatigue damage analysis is to use a so-called safety index. In the computation of such an index the coefficient of variation for the accumulated damage is needed. Employing the rainflow cycle count method for fatigue damage leads to, in most cases, complicated calculations. Here we present a new and simplified method to estimate the coefficient of variation for
The free energy of binding between avidin and seven biotin analogues has been calculated with the molecular mechanics Poisson- Boltzmann surface area (MM/PBSA) method. We have studied how the force field and the method to generate geometries affect the calculated binding free energies. Four different force fields were compared, but we saw no significant difference in the results. However, mixing t
During oxygen evolution, the Mn cluster in Photosystem II cycles through five oxidation states, S0-S4. S0 and S2 are paramagnetic, and can be monitored by electron paramagnetic resonance (EPR). Recently a new EPR signal from the S0 state was discovered [Åhrling et al. (1997) Biochemistry 36, 13148-13152, Messinger et al. (1997) J. Am. Chem. Soc. 119, 11349-11350]. Here, we present a well-resolved
Degradation of bovine nasal cartilage induced by interleukin-1 (IL-1) was used to study catabolic events in the tissue over 16 days. Culture medium was fractionated by two-dimensional electrophoresis (isoelectric focusing and SDS-PAGE). Identification of components by peptide mass fingerprinting revealed released fragments representing the NC4 domain of the type IX collagen {alpha}1 chain at days
The synthesis of a C-2-symmetric cleft molecule 2 based on the fused framework between bicyclo-[3.3. 1] nonane and 4-oxo-5-azaindole, incorporating a self-complementary hydrogen-bonding motif, in both racemic and enantiomerically pure forms is reported. This cleft molecule is reminiscent of analogues of Troger's base though with different cleft dimensions and tilt angles. The framework of 2 provid
Processing of the recycling proteoglycan glypican-1 involves the release of its heparan sulfate chains by copper ion- and nitric oxide-catalyzed ascorbate-triggered autodegradation. The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains. We have investigated the possi
Radioiodine therapy is a common form for treatment of hyperthyroidism. This treatment has been performed for half a century, with the annual number of I-131-iodide therapies for hyperthyroidism in Sweden being around 3000 since the 1970s. Methods used to calculate the administered activity to the individual patient differ widely, and a survey was made to get information about the different protoco
We present experiments with a rolling multichannel microphone array where measurements can be taken continuously while moving. Leaky air-coupled surface waves are measured with ordinary non-directional audio microphones. Results show that microphones can be successfully used to produce a realistic phase velocity spectrum even while moving along the surface. The paper presents some theoretical back
This experimental study examines the influence of moisture variations on the load-bearing capacity of steeltimber dowel joints. The glulam specimens used to manufacture the joints were first exposed to controlled climate changes. After being stored in the climate chambers, holes were drilled and dowels were inserted. Then, the joints were loaded to failure. The main aim of this study was to inv
Infants gradually learn to predict the motion of moving targets and change from a strategy that mainly depends on saccades to one that depends on anticipatory control of smooth pursuit. A model is described that combines three types of mechanisms for gaze control that develops in a way similar to infants. Initially, gaze control is purely reactive, but as the anticipatory models become more accura
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclosporin A (CsA) is well known, for its extracerebral effect, as an immunosuppressant
Participation is about finding consensus in diversity and reflects a normative shift towards multiple-use values that recognise that forest management should blend multiple management objectives into a coherent set of practices. A framework to incorporate interest groups' values and needs into functional forest management systems has yet to be institutionalised in contemporary forest policy and ma
