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Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with divers
Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com
The downscaling of environmental responsibilities poses new challenges for regional governments, necessitating an evolution in their roles to manage environmental policy alongside traditional local development duties. This paper draws on the concept of the entrepreneurial state and on the idea of the ‘entrepreneurial region’ to explore how local and regional governments implement bioeconomy polici
Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameter
Purpose: Surgical repair of parastomal hernias (PH) is challenging, mainly due to high recurrence rates. The Local Parastomal repair (LoPa) is a novel technique utilizing a retromuscular synthetic mesh with an outward-facing collar. This study describes the LoPa technique and evaluates its outcomes. Methods: This single-centre study retrospectively reviewed 39 consecutive patients who underwent Lo
Aim: To provide an overview of a project aimed at enhancing person-centred surgical care through teamwork and professional development. Design: A discursive paper with the purpose of describing and discussing the project activities to strengthen person-centred care, teamwork and professional development. Methods: This project aimed to strengthen evidence-based surgical nursing care within a Surger
Treatment response in pediatric social anxiety disorder (SAD) is highly variable, and symptoms may be maintained by maladaptive attention. A previous study found that youth with SAD scan a more restricted area of faces than healthy controls during emotion recognition, potentially limiting interpretation of social cues. The current study followed up on these results by examining whether restricted
Wages earned by men are often used as an indicator of the material standard of living (MSoL). However, this indicator relies on several assumptions when used for comparisons across time and space. Considering these assumptions will improve estimates of the MSoL from wages. One necessary assumption is that households in the compared populations relied on the primary income of the male head of house
Objective: To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKis). Methods: RA patients treated with JAKi (n=46) at the Department of Rheumatology, Skåne University Hospital, Sweden, and healthy controls (n=37) received two doses of the HZ/su vaccine. Blood samples were colle
Background/Objectives: Mitochondrial dysfunction is a major cause of brain injury in patients with primary mitochondrial disease. New mitochondrial therapeutics and non-invasive tools for efficacy monitoring are urgently needed. To these ends, succinate prodrug NV354 (methyl 3-[(2-acetylaminoethylthio)carbonyl]propionate) and diffuse optical techniques are promising. In this proof-of-concept study
Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision-making and real-time experimental control. Here, we introduce a theoretical framework that reconceptualises sma
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are rare autoimmune diseases, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophil granulomatosis with polyangiitis (EGPA). They are three distinct diseases with overlapping symptoms and signs. The ANCAs involved in AAV are mainly directed against myeloperoxidase (MPO) and proteinase
Context. Neutron-capture elements are believed to make up almost all elements heavier than iron in the periodic table. By studying the abundance of these elements throughout the Galaxy, it is possible to put constraints on how and where neutron-capture processes occur. Determining elemental abundances is made possible through the correct interpretation and modelling of astrophysical spectra. Key i
