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Wildlife-vehicle collisions (WVCs) pose significant risks to highway safety and wildlife populations, leading to considerable economic losses. However, efforts to systematically characterize and mitigate WVCs are often constrained by substantial under-reporting in official crash record databases. This study integrates police-reported crash data with carcass removal records from 7041 road segments
Tinnitus, the perception of sound without an external source, affects many individuals, yet its impact on the brain's functional connectome remains underexplored. Traditional functional connectivity (FC) methods, such as Pearson correlation, phase lag index, and coherence, rely on pairwise comparisons between activity of macro-scale brain regions, limiting holistic characterization. We used an app
Background Lower limb conditions (LLCs) are a major cause of pain, disability, and loss of livelihood globally, yet their prevalence and functional impacts in low- and middle-income countries, including Nepal, remain poorly described. Methods We conducted a cross-sectional, community-based survey in three Nepali districts representing plains, hills, and mountains. Of 2525 screened households, the
Over the past several centuries, the Baltic Proper harbour porpoise (Phocoena phocoena) has undergone significant population declines, resulting in its current IUCN classification as critically endangered. While conservation efforts are extensive and multinational, the population's abundance has only been estimated once (SAMBAH Project, 2011–2013). Ad hoc historical sources and the sub-fossil arch
Methane is emitted from a range of anthropogenic and natural sources, and identifying these sources is important for emissions monitoring and mitigation. Different sources emit methane with different isotopic signatures. However, these signatures can vary spatially and temporally and are often not well understood. Top-down inverse methods can be used with measurements of methane mole fractions to
Epidemiological studies suggest an association between Parkinson’s disease (PD) and ulcerative colitis (UC), yet the molecular programs potentially linking these disorders remain poorly defined. Here, we integrated curated disease-gene resources with publicly available blood transcriptomic datasets to identify shared molecular features across PD and UC. We identified 320 shared signature genes and
The APOE locus is the strongest genetic factor for Alzheimer’s disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across plasma and cerebrospinal fluid in GNPC, BioFINDER-2, ADNI, UK BioBank, and PPMI. APOE-associated protein alterations are detectable before amyloid pathology and remain st
We present the combined JWST/NIRSpec/G395H and NIRISS/SOSS transmission spectrum of a warm mini-Neptune, TOI-1130 b (3.66 R⊕, 19.8 M⊕, and Teq ∼ 825 K). It is part of a rare and unique multiplanet system, TOI-1130, which hosts an inner mini-Neptune and an outer hot Jupiter locked in a 2:1 mean motion resonance. From the transmission spectrum of TOI-1130 b we detect multiple molecules—H2O (7.5σ), C
OBJECTIVES: To explore the possible effects of intensive care follow-up visits and diaries on patients physical and psychosocial problems at 2, 6, and 12 months after unit discharge as well as the patient' experiences of follow-up visits and diaries.METHODS: A descriptive and explorative cohort design. Patients (n = 441) with a length of ICU stay for ≥24 hours, who responded to the 3-set 4P questi
Doughnut Economics has become an important model for planning, often assumed to offer a better, more sustainable approach. This article engages with such assumptions by critically interrogating the radical potential of doughnut planning. It does this through examining the doughnut diagram, which conceptualizes core ideas of Doughnut Economics, and by relating these to discussions in planning. The
In numerical combustion research, accurate chemical reaction mechanisms for heavy hydrocarbons are essential to investigate the flame dynamics of sustainable aviation fuels (SAF) relative to conventional jet fuels. However, accounting for hundreds or thousands of reactions makes finite-rate chemistry (FRC) large-eddy simulations (LES) impractical for realistic engineering scenarios. Here, a multid
Sufficiency policies address unsustainable consumption and production patterns by promoting ways of living and economies that prioritize “enough” over “more,” reducing resource use while safeguarding fundamental human needs. Public support is crucial for the effective implementation of sufficiency policies, yet empirical research on citizens' preferences and their underlying mechanisms remains sca
Multiple choice question tests are often the gateway to important professional outcomes. We study gender differences in willingness to guess among highly skilled and trained candidates in a high stakes multiple choice question test, before and after a reduction in the number of alternative answers to each question, lowering the penalty for incorrect answers to the critical value, i.e, the one yiel
Background: PERK (Protein kinase R-like endoplasmic reticulum kinase), encoded by EIF2AK3, is a key ER stress sensor that regulates protein synthesis and the unfolded protein response (UPR). Its dysregulation is linked to cancer development and progression. This study investigated EIF2AK3/PERK expression across 28 tumour types (n = 7,251) and their matched normal adjacent tissues (NATs; n = 667) f
Abstract – Although electroencephalography (EEG) is used to assess neonatal pain in research settings, EEG assessments have not been sufficiently characterized for use as end points to assess the efficacy of analgesics in regulatory-endorsed, industry-sponsored trials. We aimed to identify all studies conducted in neonates with EEG recordings during acute somatic nociceptive skin-breaking procedur
The Routledge International Handbook of Research Security examines research security - the act of protecting and securing university research and teaching in the name of national security - through a multidisciplinary and comparative lens. In this volume, contributors explore theoretical, domestic, international, and practical pursuits of research security across the globe. Over six sections, the
Beamstopper-Integrated Sensors (BIS) based on silicon carbide (SiC) represent a novel class of compact, radiation hard devices that combine beam interception with real-time diagnostics. We present the first characterization of four-quadrant BIS designed for simultaneous intensity and position monitoring on synchrotron beamlines. Based on the established reliability of single-pixel BIS as intensity
