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Structural optimization aims to find the geometry of the best performing design in a predefined setting, using mathematical techniques. The motivation for this study can be categorized into three main benefits: efficient material usage, enhancing existing designs and enabling new technologies. All of these benefits are crucial for solving contemporary technological and environmental challenges. An
How can a live opera performance stimulate visitor involvement by displaying immersive features!? With the AI-based chamber opera The Prophecies, we took the opportunity to structure a visitor’s journey through a series of differentiated chambers inhabited by both human and machine agents. This model was primarily informed bydistinctions made about game immersion from cognitive science and game st
Extended Reality (XR) serves as a broad term that encompasses several immersive technologies, including Augmented Reality (AR), Mixed Reality (MR), and Virtual Reality (VR). Currently, most XR devices are connected by cables, which restrict user mobility and negatively impact the overall Quality of Experience (QoE) for users. XR devices face limitations not only in terms of connectivity but also i
Background: Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fibrillary acidic protein (GFAP) and phosphorylated tau (pTau), and whether a three-way interaction exists among APOE ε4, GFAP, and pTau that influences AD progression remain unclear. Method
This paper examines the emerging concept of hybrid intelligence, the collaboration between humans and AI, and its growing importance in sensemaking processes across diverse organizational contexts. While hybrid intelligence offers significant potential for progress, the integration of responsibility into this collaborative framework remains a crucial challenge. Current research often explores huma
Mental health assessments increasingly rely on remote formats that produce rich but complex multimodal data in the form of text, audio, and video, processed through multiple machine learning models. While these environments offer new opportunities for insight, they also pose significant challenges for effective clinical sensemaking. This study introduces a dashboard designed to address these chall
The goal of the VAST challenge 2019 Mini Challenge 2 was to visualize radioactive contaminations measured by mobile and static sensors and their changes over time, allowing city officials to determine the severity of the leakage at the city's nuclear power plant. We propose cpmViz, a web-based tool that allows for interactive data exploration of the sensor readings in both of the spatial and tempo
As 6G networks evolve, offloading extended reality (XR) applications emerges as a key use case, leveraging reduced latency and edge processing to migrate computationally intensive tasks, such as rendering, from user devices to the network. This enables lower battery consumption and smaller device form factors in cellular environments.However, offloading incurs delays from network transmission and
Background: The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [18F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients. Methods: A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion upt
Context. The nuclear stellar disc (NSD) is a rotating, disc-like structure in the Galactic centre; it is believed to have a distinct star formation history and a predominantly old stellar population. However, its formation history and evolutionary links to other structures in the Galactic centre remain uncertain. Studying the chemical evolution of the NSD could provide new insights into this regio
Background: Although Kirsten rat sarcoma virus (KRAS) mutations represent the most frequent oncogenic driver alterations in Caucasian lung adenocarcinoma (LADC) patients, their impact on immune phenotype and tumor morphology is largely unexplored. Here, we investigated the associations between KRAS mutation subtypes, immune landscape, and tumor heterogeneity in surgically treated LADC, with a part
Purpose: Cancer affects a great number of people during working life, and tailored interventions targeting this population are important. The present study, focused on the developmental phase of a work-oriented intervention, aimed to describe work-related experiences and needs among people undergoing curative cancer therapy. Methods: People (n = 22, age md 55 years, range 39–64, purposive sampling
Objectives: This work aims to present epidemiological data on penile cancer from the Nordic region (Denmark, Finland, Iceland, Norway, Sweden) and discuss the results in light of the present knowledge and possible future treatment strategies. Patients and Methods: All patients diagnosed with penile cancer in the Nordic countries between 2000 and 2022 were identified in the NORDCAN database. Data o
Incidence of early-onset (< 40 years) type 2 diabetes (T2D) is increasing. While multiple risk factors have been identified, particularly obesity and low socioeconomic status, early-life factors are hypothesised to play a role via fetal programming. We investigated sociodemographic and early-life factors in relation to early-onset T2D using a family-based design that accounts for shared genetic an
