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Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improves outcome for patients with estrogen receptor-positive (ER+) metastatic breast cancer, but drug resistance and thus disease progression inevitably occur. Herein, we aimed to identify genomic alterations associated with combined CDK4/6i and endocrine therapy resistance, and follow the levels of specific mutations in long
Background: Osteonecrosis (ON) is a potentially disabling skeletal complication of cancer treatment. Although symptomatic osteonecrosis (sON) is well-known in acute lymphoblastic leukemia (ALL), with an incidence around 6%, studies on sON in pediatric Hodgkin lymphoma (HL) are scarce. The aim of this study was to examine the incidence, risk factors, and outcome of sON in children treated for HL. P
Several digestive system models have been developed, varying in sophistication. These models measure under dynamic, semi-dynamic, or batch conditions, with notable distinctions between them. This chapter covers models for gastrointestinal digestion, including static and dynamic models, and important aspects of digestion and fermentation, such as bioaccessibility, bioavailability, and bioconversion
Offspring sex ratios may deviate from parity when the fitness benefits of producing male or female offspring vary. We tested for sex ratio bias in smooth-billed anis Crotophaga ani, a communal laying cuckoo with low within-group relatedness and high offspring dispersal. One male group member performs nocturnal incubation and sires more offspring than other males in the group, suggesting males may
Obesity is a major risk factor for metabolic and cardiovascular disease in adults. The Framingham Heart Study was established to follow the development of cardiovascular disease (CVD) over a long period of time and to identify major risk factors for premature death. 1 The study was one of the first to show that obesity is a major risk factor for CVD in adults.
Despite the importance of fungi to forest carbon (C) cycling and increasing calls to include microbial interactions in ecosystem models, how shifting fungal guild abundances impact soil C stocks remains poorly quantified, particularly in mineral soils where most C is stored. Additionally, a greater understanding of how fungal interguild interactions affect belowground litter decomposition is neede
Background: Family is a crucial social institution in end-of-life care. Family caregivers are encouraged to take on more responsibility at different times during the illness, providing personal and medical care. Unpaid work can be overburdening, with women often spending more time in care work than men. Objectives: This study explored multiple views on the family’s role in end-of-life care from a
Importance: The lack of an in vivo measure for α-synuclein (α-syn) pathology until recently has limited thorough characterization of its brain atrophy pattern, especially during early disease stages. Objective: To assess the association of state-of-the-art cerebrospinal fluid (CSF) seed amplification assays (SAA) α-syn positivity (SAA α-syn+) with magnetic resonance imaging (MRI) structural measur
This article is concerned with the historical evolution of the mining industry in Canada since 1859. The focus is directed on changes that occurred in the industry and allows for the identification of four distinct mining regimes. These regimes are defined using the Regulation Theory, which connects conditions of production, technical progress, financial structures, and social relations. The ident
Between 1980 and 2000, total employment in the Canadian mining sector halved. While the literature on resource economy is thriving in Canada, little is known about how local labor markets experienced such a decline. This article presents a novel strategy to measure the effects of mine closures on local direct, indirect, and induced employment. This ripple effect is estimated using impulse response
Aims and background: Whole-genome sequencing (WGS) is increasingly applied in clinical practice and expected to replace standard-of-care (SoC) genetic diagnostics in hematological malignancies. This study aims to assess and compare the fully burdened cost (‘micro-costing’) per patient for Swedish laboratories using WGS and SoC, respectively, in pediatric and adult patients with acute lymphoblastic
In this study, we simulate the automatic control of an electric wheelchair for indoor Pac-Man-style navigation using solely thought commands. We delve into the decision-making mechanisms of an operational EEG-based brain computer interface that employs a visual oddball paradigm. We investigate strategies to enhance the efficiency of decision-making processes, aiming to accelerate response times wh
Clinical reasoning and decision-making in prehospital contexts are complex, and patient assessments may be influenced by stress or biases, thus potentially risking patient safety. Previous research has shown mixed results regarding cognitive interventions designed to counteract biases and improve decision-making. In educational settings, there are no tools that assess clinical reasoning while also
Background and Objectives: Animal studies have suggested a link between benzodiazepine and related Z-drug (BZDR) use and immune dysfunction. Corresponding evidence in humans is limited and focuses mainly on pneumonia. This study aimed to assess the association of incident BZDR use with subsequent development of serious infections. Methods: This Swedish register-based study included a population-ba
The Sjuøyane archipelago is the northernmost land area of Svalbard; thus, it provides a window to study the terrestrial glacial history and dynamics of the Svalbard–Barents Sea Ice Sheet and complement marine geological studies in the region. To reconstruct the glacial history of Sjuøyane, we describe coastal sedimentary sections in Quaternary sediments and constrain their chronology by radiocarbo
Osteonecrosis (ON) is a common complication of glucocorticoid-based Hodgkin lymphoma (HL) treatment, but the natural evolution and prognosis of ON lesions remain poorly understood. We describe the radiological evolution of ON lesions identified in a Nordic population-based cohort of paediatric HL patients. Magnetic resonance images of suspected ON lesions were centrally reviewed to confirm ON diag
A parent’s life threating illness and death can significantly affect their children's wellbeing in both the short and long term. Support from professionals is recommended when parents lack the ability to help children cope with loss, bereavement, and grief. The overall aim of this dissertation was to illuminate professionals’ encounters with children of a seriously ill or deceased parent and to ex
This qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environ-ment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theoryand the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizationalcommunication web. The results indicated that thisThis qualitative study explores how communication practice affects Swedish home care nurses’ psychosocial work environment. Data consisted of interviews and field observations, analyzed from the perspective of Media Synchronicity Theory and the Job-Demand-Control-Support model. Individual home care nurses were found to manage an interorganizational communication web. The results indicated that thi
Objective: The scientific literature reports on how social media potentially influences eating disorders, although there is a large gap in the specific case of TikToks influence of adolescent's recovery from anorexia nervosa (AN). Our study uses in-depth interviews with female adolescents primarily suffering from AN to explore how they perceive the social media platform TikTok in relation to their
