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Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressively destructive polyarthritis. Key autoimmune features include the presence of autoantibodies. The purpose of this review is to discuss the diagnostic and prognostic properties of rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA), based on current use in Swe
This paper critiques the implementation of the EU's Smart Specialization Strategies (S3), advocating for a deeper analysis of the long-term evolution of regional industrial portfolios. We investigate the changing coherence of these portfolios across 401 German NUTS-3 regions from 1993 to 2018, utilizing skill- and task-based metrics for relatedness and complexity, alongside sequence analysis and o
Understanding to what extent phenotypes vary in their physiological traits and their associations to life-history strategies may help to better understand how animals are adapted to their environment and how they can cope with changing conditions. Melanin-based colour polymorphism is a phenotypic trait closely associated with physiological characteristics and fitness, which in tawny owls (Strix al
This paper reports results from a trust game in which trustors, before deciding on their transfer, are shown a statement about the perception of the situation by another person. Statements expressed either suspicion, insecurity, worry of disappointment or curiosity. Trustors first had to indicate their identification with the statement before making trust game decisions. Compared to a standard tru
We have investigated the bacterial decomposition of dissolved organic matter (DOM) extracted from the organic layer of a boreal forest soil and filtered at a pore size of 0.2 µm. This DOM source has previously been extensively characterized and contains approximately equal amounts by carbon of a colloidal fraction, mainly composed of carbohydrates, and a fraction of molecularly dissolved DOM. Here
Private-sphere conversations about global environmental change play an important role in environmental communication. However, they receive less attention than information campaigns aimed at raising awareness, educating, or challenging the public. From a psychological perspective, it is increasingly recommended to talk about global environmental change and the emotions it evokes as a way of coping
Galectins are a family of carbohydrate-recognising proteins involved in regulation of cell adhesion and cell signaling, leading to roles in e.g. cancer progression, fibrosis, and ulcerative colitis. Glycomimetic galectin inhibitors based on different molecular scaffolds are known and have demonstrated effects from cell experiments to the clinic. Presented here is the synthesis and evaluation of 3-
Hydromechanical models of Darcy–Brinkman–Stokes type consider mass- and momentum conservation of an incompressible fluid on a domain with varying permeability. They include the two important limits of free flow governed by the classical Navier–Stokes equations and porous Darcy flow. The conceptual simplicity makes the model attractive from a modeling perspective, but any numerical solution procedu
The synergistic integration of biologics and additive manufacturing (AM) technologies has catalyzed groundbreaking advancements in spinal surgery. These innovations address persistent challenges, such as optimizing fusion outcomes, enhancing tissue regeneration, and achieving precise anatomical compatibility. Biologics have transformed spinal fusion by facilitating bone formation and promoting ost
Blog post at Strasbourg Observers
There is an ongoing debate about what should be considered an energy community (EC), particularly in terms of citizen engagement and the proximity of community members to renewable energy production. The type of EC that exclusively engages with actors in a certain geographical location is defined as a community of place (COP). In contrast, communities of interest (COI) do not limit membership to t
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcrip
Background: Patients with irritable bowel syndrome (IBS) are often interested in dietary interventions as a means of managing their symptoms. However, the relative efficacy of available diets for the management of IBS is unclear. We aimed to examine the relative efficacy of various dietary interventions in IBS. Methods: For this systematic review and network meta-analysis we searched MEDLINE, EMBA
Glycopolymers are versatile materials for biomedical and healthcare applications, e.g., as carrier and polymeric therapeutics. Especially, the topology and surface composition of such materials play a key role in being promising materials in the anti-amyloidogenic interventions. Herein, 2nd and 3rd generation of pseudo-glycodendrimers (PGDs), based on hyperbranched polyester core with different su
Major Depression (MD) and General Anxiety Disorder (GAD) are the most common mental health disorders, which typically are assessed quantitatively by rating scales such as PHQ-9 and GAD-7. However, recent advances in natural language processing (NLP) and machine learning (ML) have opened up the possibility of question-based computational language assessment (QCLA). Here we investigate how accurate
Double cones have been described in the retinae of both fishes and tetrapods. While fish double cones are two closely attached single cones, the two members of tetrapod double cones each evolved to be distinctly different from all single cones.
The evolution of reproductive isolation is a key evolutionary process, but the factors that shape its development in the early stages of speciation require clarification. Here, using a meta-analysis of 34 experimental speciation studies on arthropods, yeast and vertebrates, we show that populations subject to divergent selection evolved stronger reproductive isolation compared with populations tha
