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Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin III derivative or 10-deacetyl-baccatin III derivative to obtain a mixture of isomers; separating the isomers via chromatography; and carrying out a reversion of t
Frequent wildfires increasingly impact tourist populations, yet there is a shortage of evidence-based, human-centered tools for wildfire risk reduction tailored to these areas. Most current tools focus primarily on assessing and reducing physical vulnerabilities, overlooking human aspects. While some community wildfire management guidelines exist, actionable strategies for disaster managers to add
The rapid development of generative AI has prompted a surge in future-oriented documents on a wide range of anticipated educational concern within the Nordic welfare state. Among these, the roadmap has become an increasingly popular foresight technique, exemplified by the AI Commission’s Roadmap for Sweden, which is the focus of the paper. Mobilised within an anticipatory regime of future thinking
This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of pac
Tracking animal displacement on video recording is a frequently used method in ethology, behavioral ecology, and neuroscience to characterize animal behavior in an automated and objective way. We propose here a quick-start tutorial of AnimalTA, a video tracking program, which aims to provide a free, open-source, and user-friendly tool for the scientific community. The strength of this software res
Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
The present invention relates to a method of removing an endotoxin from solution containing basic proteins. More specifically, the method of the present invention comprises the steps of adding the surfactant to solution containing the basic protein obtained from the recombinant microorganism and mixing the resultant, of loading the resultant solution on the cation exchange column, washing the cati
The practices of doctoral education are intricately entangled with technologies. This methodological paper examines the practical concerns involved in doing the analytic work in a networked learning setting with Actor-Network theory (ANT). It is a story about engaging with ANT as a companion in an ethnographic research project on teaching practices in Sweden during the Covid-19 pandemic. The empir
The paper explores what the methodological considerations are for a study of educational practice and networked learning in technologically dense classrooms. The approach of the discussed study is informed by Actor-Network Theory (ANT) (Latour, 2005) and the paper outlines the methodological consequences for adopting principles associated with ANT and post-humanist critiques of representational ep
Controlling the surface morphology and chemical interaction is necessary for the development of advanced quantummaterials, particularly in low-dimensional systems. As the research increasingly focuses on miniature and nanoscaletechnologies, a fundamental understanding of localized or interface states becomes essential for successful integrationinto functional devices. This thesis investigates atom
Chemical exchange saturation transfer MRI is a promising magnetization transfer (MT) imaging technique that utilizes, by radiofrequency irradiation, selective saturation of exchangeable protons in solutes. This enables the indirect detection of the solutes through the water signal after saturation transfer by chemical exchange, cross-relaxation, or the combination of the two. Typically, the water-
INTRODUCTION: Epidemiological studies focusing on the association of exposure to perfluoroalkyl substances (PFAS) with cardiovascular disease (CVD) morbidity and mortality are limited, with inconsistent findings.OBJECTIVES: This register-based study aimed to investigate the associations between exposure to PFAS and the risk of CVD morbidity and mortality in a Swedish population exposed to PFAS, do
This study investigated the associations between solar and geomagnetic activity and circulating biomarkers of systemic inflammation and endothelial activation in the Normative Aging Study (NAS) cohort. Mixed effects models with moving day averages from day 0 to day 28 were used to study the associations between solar activity (sunspot number (SSN), interplanetary magnetic field (IMF)), geomagnetic
Estrogen influences T cell development and enhances infection resistance in females, but its immunological effects during gender-affirming hormone therapy (GAHT) remain poorly understood. Here, we characterize immune adaptations in male rhesus macaques (RMs) treated with 17β-estradiol (E2) or placebo over 7 months. E2 therapy suppressed endogenous testosterone production, induced female physical t
Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and prevalence of autoimmunity. Intrinsic biological sex differences arise from varying contributions of chromosomal sex, and sex hormone sensing and downstream signa
OBJECTIVE: To externally validate the Paediatric Emergency Care Applied Research Network (PECARN) rule for identifying febrile infants aged <60 days at low risk of serious bacterial infections (SBIs) and assess the utility of the rule with C reactive protein (CRP) instead of procalcitonin (PCT).METHODS: Secondary analysis of data from the Management and Outcomes of Fever in Children in Europe (MOF
