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(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major a
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu
OBJECTIVE: To investigate the relationship between the fraction of fetal haemoglobin (HbF(%)) and oxygen requirement as determined by the fraction of inspired oxygen (FiO2) and alveolar-arterial gradient (A-a gradient). Increased alveolar exposure to oxygen may explain the association between decreased HbF(%) and the development of bronchopulmonary dysplasia (BPD).DESIGN: Longitudinal, retrospecti
Breast cancer, a common and often aggressive malignancy, presents significant challenges due to its ability to develop resistance to therapies. This resistance is intricately linked to the function and regulation of the estrogen receptor, a key driver of breast cancer cell proliferation. Our research focuses on unraveling the complex mechanisms underlying this resistance by investigating the roles
The collection contains hitherto unpublished poems from the period 2017 - 2020
The risk of sports participation in elite athletes with cardiac disease with an indication for implantable cardioverter-defibrillator (ICD) therapy is largely unknown. Currently, international guidelines provide restrictive sports advice for such athletes. This case report presents a professional football player who after an episode of syncope and diagnosis of apical hypertrophic cardiomyopathy ex
Bokverkets första del behandlar tiden från istidens slut ca 10000 år före vår tideräkning fram till 1658 då Blekinge blev svenskt. I del 1 behandlas stenålderns och metalltidernas kontakter, mobilitet, gravskick, boplatser, näringsförhållanden. Profana och religiösa maktförhållanden analyseras liksom bebyggelse, kultur- och naturförhållanden. Handeln belyses via vattenvägarna, de tidiga städerna,
Avfallshantering i historisk tid, i nutid och i framtiden.
Objective: To assess changes in morphology and size of endometriomas during pregnancy and after delivery.Design: This was a prospective observational cohort study performed during 2013 - 2024 at a tertiary care center (Ultrasound Unit, Department of Obstetrics and Gynecology, Skane University Hospital, Malmo, Sweden). Women were offered repeated ultrasound examinations every month during pregnancy
Cellular communication within the brain is imperative for maintaining homeostasis and mounting effective responses to pathological triggers like hypoxia. However, a comprehensive understanding of the precise composition and dynamic release of secreted molecules has remained elusive, confined primarily to investigations using isolated monocultures. To overcome these limitations, we utilized the pot
Although very few people appear to travel to the Nordic region in contexts that might accurately be described as ‘climate-related,' some Nordic states have developed bespoke legal provisions, and all have ‘exceptional grounds’ categories that may be applied when people seek to enter or remain in the context of climate change or disaster. This chapter provides a brief overview of legal provisions r
The anesthetic drug propofol is commonly used to control hypnotic depth (suppression of awareness) in patients undergoing surgery or intensive care. In addition to manual titration, a model-based open-loop feed-forward strategy called target-controlled infusion (TCI) has attained some clinical popularity. Research on closed-loop control, with awareness estimates derived from an electroencephalogra
The global COVID-19 pandemic fundamentally changed education as we know it. Globally, billions of learners at all levels were affected by months of rolling school closures and other severe pandemic restrictions to daily life. Magnifying issues of educational equity, access, and opportunity, this unprecedented global crisis forced Deans, and academic and professional staff in schools of education tThe global COVID-19 pandemic fundamentally changed education as we know it. Globally, billions of learners at all levels were affected by months of rolling school closures and other severe pandemic restrictions to daily life. Magnifying issues of educational equity, access, and opportunity, this unprecedented global crisis forced Deans, and academic and professional staff in schools of education t
