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BACKGROUND: Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor.METHODS: In a syngeneic mouse model of breast cancer, tumors expressing SUSD4 had a smaller volume compared with the corresponding mock control tumors. Additionally, data from th

Open science aims to improve research accessibility, replicability, and consequently its quality. Empirical software engineering entails both data and artifacts, which may be shared more or less openly, to support transparency. However, the trade-offs involved in balancing the openness against integrity and secrecy concerns need methodological guidance. Aim. We aim to derive such advice, based on

Kapitlet diskuterar vilken roll systemintermediärer spelar för att främja innovation i lokala ekosystem. Fallet som studeras är hur Lunds kommun tillsammans med andra aktörer har valt att bygga upp en särskild organisation, Future by Lund, för att tillsammans driva frågor som rör samhällsutveckling. Utgångspunkten är att dagens innovationspolitiska insatser i stor utsträckning fokuserar på samhäll

Radionuclides released and discharged into the environment from nuclear and other radiation-related facilities, such as the European Spallation Source (ESS), may accumulate in aquatic bottom sediments. Sediments should therefore, as recommended by the IAEA, be monitored regularly. This report describes the setting up of a methodology for zero-point assessments of the radiation levels in sediments

Responsible internationalization is a term increasingly used to promote relationship building in a world shaped by the growing impact of global challenges and geopolitical competition. In these changing global conditions, researchers and universities have learned that they need to adhere to an expanded set of research norms. Today these norms include aspects well known to researchers, such as rese

Under de senaste åren har säkerhetsrisker med internationella forskningssamarbeten alltmer uppmärksammats. Det har därför från politiska aktörer i Sverige betonats att tydligare hantering av säkerhetsrisker kommer att krävas från statligt håll. Denna artikel beskriver den utveckling som setts i Sverige de senaste åren och diskuterar utmaningar med ett ökat säkerhetsfokus. Framför allt finns det en

Borealis - a Festival for Experimental Music is a yearly 5-day New Music festival in Bergen, Norway that has implemented numerous DEI (diversity, equity, and inclusion) initiatives since 2015 in its programming and festival organisation. This 20-minute presentation will draw on the results of my institutional ethnographic analysis of the festival in order to analyse the work of its festival team.

Sundbyberg kommun har genomfört en ombyggnation av en del av Ursviksvägen. En traditionell tvåfilig väg med skyltad hastighet på 30 km/tim byggdes om till en fil för bilar och två cykelfält, en på vardera sida om körfältet för bilar, det vill säga en 2 minus 1-väg. Före ombyggnation och efter ombyggnation tillfrågades boende och passerande individer om deras upplevelser av Ursviksvägen. I synnerhe

Shared spaces är tänkta att inbjuda till ett levande stadsrum för alla samtidigt som trafiksäkerheten säkerställs genom att den traditionella uppdelningen mellan oskyddade och skyddade trafikanter tas bort. Tanken är att borttagandet av den traditionella uppdelningen ska skapa en viss osäkerhet som i sin tur ska bidra till större försiktighet. Syftet med detta projekt var därför att undersöka bili

Based on the physical and geographical conditions, the Baltic Region is categorised as a humid climate zone. This means that, there is usually more precipitation than evaporation throughout the year, suggesting that droughts should not occur frequently in this region. Despite the humid climate in the region, the study focused on assessing the spatio-temporal patterns of droughts. The drought event

This paper considers an allocation problem with a finite number of objects and unit-demand agents. The main result is a characterization of a class of strategy-proof price mechanisms on a general domain where preferences over pairs of objects and houses are rational, monotonic, and continuous. A mechanism belongs to this class if and only if the price space is restricted in a special way and, give

The cytokine IL-23 plays important roles in intestinal barrier protection and integrity, but is also linked to chronic inflammation. In this issue of JEM, Ohara et al. (https://doi.org/10.1084/jem.20230923) provide clarity on the much-debated question of which cells produce IL-23.

Sodium-glucose transport protein 2 inhibitors (SGLT2i) slow the progression of renal dysfunction and improve the prognosis of patients with heart failure. Amyloidosis constitutes an important subgroup for which evidence is lacking. Amyloidotic fibrils originating from misfolded transthyretin and light chains are the causal agents in ATTR and AL amyloidosis. In these most frequent subtypes, cardiac

The donor (BTR-Cl) and acceptor (BTP-FCl-FCl) have well-defined small molecule properties and excellent repeatability, and they can form charge transfer complexes with a wide spectral absorption range. Using density functional theory (DFT), we simulate the photoinduced charge transfer of bulk-heterojunction (BHJ) organic solar cell (OSC) materials modulated by the external electric field (Fext) at

A phytochemical investigation of Curcuma zedoaroides rhizomes resulted in the isolation of ten sesquiterpenes (1–10) and two diterpenes (11−12). The structure of compounds 1–12 was identified as phaeocaulisin E (1), zedoarondiol (2), isozedoarondiol (3), isoprocurcumenol (4), neoprocurcumenol (5), procurcumenol (6), 1-epi-procurcumenol (7), aerugidiol (8), curcumenol (9), curcumenone (10), curcumi

Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an increased risk of developing multiple sclerosis. The objective of thi

Recovery of the collagen structure following Achilles tendon rupture is poor, resulting in a high risk for re-ruptures. The loading environment during healing affects the mechanical properties of the tendon, but the relation between loading regime and healing outcome remains unclear. This is partially due to our limited understanding regarding the effects of loading on the micro- and nanostructure

More granular grading scales provide a more accurate assessment of achievement and thus provide students with more informative feedback on their performance. Using Swedish administrative data and exploiting a natural experiment, we identify the effects of moving from a system with three passing grades to one with five passing grades. Students receiving more informative grades are less likely to gr

Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT