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Detailed atomic structures are key to understand and evaluate catalytic activity, ligand binding affinities and many other properties. Neutron crystallography is a popular method for deriving structures of proteins. Unfortunately, the experimental data is typically not enough to settle the exact position of all atoms. Therefore, empirical restraints are employed to ensure that the final structures
BACKGROUND The evidence for temperature control for comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects of hypothermia differ per the circumstances of the cardiac arrest or patient characteristics. METHODS An individual patient data meta-analysis of the Targeted Temperature Management at 33◦C versus 36◦C after Cardiac Arrest (TTM) and Hypothermia vers
Mood is a pervasive affective state that influences cognition, including language processing, where it functions as part of the pragmatic context. When linguistic expressions carry emotional valence, mood may amplify or attenuate their perceived emotional nature. Motivated by inconsistent findings on the timing and nature of mood and valence interactions, we conducted an EEG study to investigate w
Second language acquisition (SLA) research has historically prioritized classroom-based contexts, with the exception of areas such as study abroad, incidental and self-directed learning. In the last decades, however, research interest in second language (L2) learning beyond the classroom has grown substantially, expanding our understanding of where and how L2 learning takes place. This can be larg
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk threshold. Methods: In a retrospective case–control study, we evaluated risk prediction performance in 180,398 women (
This study concerns democracy in education examined through the lens of small-group instrumental teaching. Traditionally, one-to-one teaching in a master–apprentice approach has been the established norm for instrumental teaching and the same model has long characterised instrumental teaching in Sweden’s art and music schools (SAMSs, kulturskolor).1 However, although individual teaching is still t
Objective: The aim of this study was to achieve an international expert consensus on managing acute type B penetrating aortic ulcers (PAUs) and intramural haematomas (IMHs). Methods: A modified Delphi consensus process was employed to develop recommendations for the management of acute type B PAU and IMH. Surveys were sent to international experts practicing in high volume aortic centres worldwide
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
This thesis presents a scoping review of academic literature on the intersection of religion, spirituality, and Indigenous worldviews with climate change adaptation. While adaptation research has traditionally emphasised technical, institutional, and financial dimensions, the cultural and spiritual dimensions shaping community responses remain underexplored. To address this gap, the review systema
Background: We aimed to investigate if early life marine n-3 fatty acids and fish intake, and fatty acid desaturase (FADS) genetic variants, were associated with later risk of celiac disease (CeD).Methods: Among 85,244 children in the prospective Norwegian Mother, Father, and Child Cohort Study, fish and marine fatty acid intakes were estimated from questionnaires to mothers during pregnancy, and
BACKGROUND: Several studies have sought to investigate gambling craving and its potential contribution to gambling problems. One aim of this line of research has been to further examine whether craving should be considered a separate diagnostic criterion for gambling disorder, which it currently is not. The present study aimed to investigate the relationship between craving and other risk factors—
ObjectiveDopaminergic medications are commonly prescribed for Parkinson's disease (PD), restless legs syndrome, pituitary and psychotic disorders. Accumulating evidence indicates that dopaminergic treatment triggers impulsive-compulsive behaviors (ICBs), yet systematic synthesis of clinical evidence remains limited.MethodThis scoping review summarizes original research directly clinically relevant
OBJECTIVE: It is unknown how risk factors for infection after transrectal prostate biopsy interact. We designed a study to evaluate this.METHODS: We identified biopsy procedures from 2006 to 2020 in the Swedish nationwide database PCBaSe. Primary outcome was post-biopsy infection, defined as a dispensed prescription of a urinary tract antibiotic and secondary outcome was inpatient care for infecti
ImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA survivImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA surviv
OBJECTIVES: Implementation of the Stroke Action Plan for Europe (2018-2030) (SAP-E) was initiated in 2019. It is now updated at mid-term to reflect and respond to challenges for stroke care in Europe in 2025. METHODS: The SAP-E covers the entire chain of stroke care. The sections (state of the art, current status and targets) were developed by working groups and finalised based on inputs from the
Using population-wide data on Swedish university researchers and teachers, we identify the effects of parenthood on academic careers. Leveraging staggered event-study models that compare mothers and fathers around first birth, we document widening gender gaps in publication output, wage income, promotion, and PhD completion. These gaps arise across all scientific fields. We further document substa
We provide a detailed characterization of the planetary system orbiting HD 85426 (TOI-1774). This bright G-type star (: 0.99;: 1.13; age: 7.4 Gyr; V mag: 8.25) hosts a transiting sub-Neptune, HD 85426 b, with an orbital period of 16.71 d and a blackbody equilibrium temperature of K. By jointly analysing HARPS-N RVs, TESS, and CHEOPS photometric data and using two different stellar activity mitigat
Over four decades, Indigenous Sámi individuals and communities have submitted to United Nations human rights treaty bodies, including the Human Rights Committee, several complaints in respect of the three Nordic countries Finland, Norway, and Sweden. Many of these Sámi rights cases have made important contributions to the understanding and application of Indigenous peoples’ rights globally, in add
