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Phlorotannins, the polyphenols mostly found in brown seaweeds, have attracted high attention from the pharmaceutical industry in recent years due to their antioxidant, antibacterial, and anti-inflammatory activities. These properties make them desirable to be utilized in a wide range of therapeutics. Despite their importance, several challenges make their extractability and identification complex,
Organizations may be confronted with both expected and unexpected events that challenge their abilities to provide these services uninterrupted. Traditional strategies based on anticipation and planning are primarily useful for expected events, but for unexpected events, organizations must develop capacities to adapt to situations and conditions not foreseen. As systems and societies are becoming
The process of industrialization is typically associated with urbanization and a large urban-rural gap in productivity and skills. To what extent were these disparities driven by the direct impact on occupational attainment of living in an urban area or the result of the positive self-selection of migrants moving to cities? In this paper, we leverage exceptional Swedish longitudinal data that allo
In this contribution we present the preliminary results regarding laser-driven nuclear isomer-production obtained during the commissioning of 1 PW-E7 experimental area at ELI-NP. The study of nuclear isomers production and their photoreactions has been a subject of lasting interest in the nuclear physics community. Nuclear isomers play a crucial role in the creation of the elements in the Universe
Swedish multifamily housing is dominated by warm-rent apartments, where heating is included in the rent. This, together with low inequality and an extensive social security system, has been argued to protect a large part of the Swedish population from energy poverty. However, during the energy crisis of 2021–2023, energy poverty quickly rose on the public agenda. In this paper, we challenge the do
Background: Substance use disorder (SUD) is associated with elevated suicide risk. The aim was to compare health care contacts as well as clinical and suicide-specific characteristics in individuals with and without substance use issues who died by suicide. Methods: Data were derived from a nationwide medical record review of confirmed suicides in Sweden. In the current study we included individua
This paper reviews the state of knowledge on past and present storms and marine coastal flooding (MCF) events of various origins within the Baltic Sea, which is an economically and environmentally important part of northwestern Europe. We show that the combination of sedimentary, historical and instrumental records provides the most comprehensive insight into the history of storms and MCF. The fre
Massively parallel sequencing (MPS) is increasingly used in forensic DNA analysis for SNP and STR genotyping, though accredited proficiency tests remain limited. To address this, five forensic DNA laboratories from four countries participated in a study to assess MPS methods across different kits and platforms. In this study ForenSeq DNA Signature Prep Kit, ForenSeq MainstAY kit, Precision ID Glob
Miniaturisation can influence the foraging behaviour of flower visitors by shaping their sensory systems, flight capabilities, and their compatibility with floral shapes and structures. For bees, vision is a primary sensory modality, and a reduction in eye size compromises the resolution and sensitivity of vision. In Tetragonula iridipennis, a diminutive tropical stingless bee common in South Asia
Aims: To examine how educational attainment impacts clinical presentation and pharmacological treatment at type 2 diabetes (T2D) diagnosis. Methods: Cross-sectional analysis of 10,020 individuals with recently diagnosed T2D enrolled in the Danish prospective DD2 cohort. Sex- and age-adjusted prevalence ratios (aPRs) for detailed clinical characteristics and pharmacotherapy were computed. Results:
Introduction: Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for acquired cardiovascular disease and mortality – more so than patients without CHD. In the general population, health related quality of life (HRQoL) is associated with regular physical activity. It was the aim of this study to evaluate the most important predictors of HRQoL
We consider waveform iterations for dynamical coupled problems, or more specifically, PDEs that interact through a lower-dimensional interface. We want to allow for the reuse of existing codes for the subproblems, called a partitioned approach. To improve computational efficiency, different and adaptive time steps in the subsolvers are advisable. Using so-called waveform iterations in combination
Aim: To qualitatively assess an intervention for ambulance nurses, including simulation training concerning intimate partner violence (IPV), and to describe the ambulance nurses’ experiences of their work after the intervention. Background: IPV is a common public health issue with serious consequences from individual and societal perspectives. Previous research indicates that deficits in knowledge
Trauma accounts for around 4.4 million deaths annually and is among the leading causes of death, disproportionately affecting low- and middle-income countries. Trauma quality improvement programmes may reduce adverse patient outcomes but lack robust evidence. This study assessed the effect of implementing a trauma quality improvement programme using audit filters on health-related quality of life
Small neutral organic compounds have traditionally the role of EOF markers in electrophoresis, as they are expected to have zero electrophoretic mobility in external electric fields. The BGE contains, however, ions that have unequal affinities to the neutral molecules, which in turn results in their mobilization. In this study we focused on two EOF markers-thiourea and DMSO, as well as on N-methyl
Release of halide ions is an essential step of the catalytic cycle of haloalkane dehalogenases. Here we describe experimentally and computationally the process of release of a halide anion from the buried active site of the haloalkane dehalogenase LinB. Using stopped-flow fluorescence analysis and umbrella sampling free energy calculations, we show that the anion binding is ion-specific and follow
Neutron diffraction with isotopic substitution was performed on aqueous solutions of isopropyl alcohol and isopropylamine. The difference between these two measurements primarily contains information about the different hydration of the alcohol and amino group. This data is used as a test of the accuracy of molecular dynamic simulations of the same systems. Having established the level of accuracy
Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. This reaction supports S-adenosylmethionine biosynthesis, which is required for hundreds of methylation reactions in humans. Herein we report that BHMT is activated by potassium ions with an apparent KM for K+ of about
A combination of Fourier transform infrared and phase transition measurements as well as molecular computer simulations, and thermodynamic modeling were performed to probe the mechanisms by which guanidinium (Gnd+) salts influence the stability of the collapsed versus uncollapsed state of an elastin-like polypeptide (ELP), an uncharged thermoresponsive polymer. We found that the cation's action wa
