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Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors, which for many years was considered to be a ubiquitous phenomenon. However, the understanding of differences in the EPR-effect betwe
Background and purpose We analysed the positional and structural stability of a long-term biodegradable liquid fiducial marker (BioXmark) for radiotherapy in patients with locally advanced lung cancer. Material and methods Markers were injected via endoscopic- or endobronchial ultrasound in lymph nodes and reachable primary tumours. Marker volume and Hounsfield Units (HU) changing rates were estim
The ecosystem-atmosphere flux of biogenic volatile organic compounds (BVOCs) has important impacts on tropospheric oxidative capacity and the formation of secondary organic aerosols, influencing air quality and climate. Here we present within-canopy measurements of a set of dominant BVOCs in a managed spruce- and pine-dominated boreal forest located at the ICOS (Integrated Carbon Observation Syste
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes
Waste management policies aim to divert waste from lower positions on the waste hierarchy such as landfill and incineration to higher positions in the hierarchy such as energy recovery and recycling. However, empirical evaluations of such policies are scarce. This study highlighted the effect of waste management policies on the amount of waste treated with landfill, incineration, energy recovery aWaste management policies aim to divert waste from lower positions on the waste hierarchy such as landfill and incineration to higher positions in the hierarchy such as energy recovery and recycling. However, empirical evaluations of such policies are scarce. This study highlighted the effect of waste management policies on the amount of waste treated with landfill, incineration, energy recovery a
Since its heyday in the 1960 and 70s, the sociology of literature has been declared dead and gone, yet research related to the field also seems to be reemerging in the first decades of the 21st century. Research relating to the field is scattered across other disciplines, such as literary studies, media studies and cultural studies; indeed, sociology of literature is “everywhere and nowhere”, as J
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Vast amounts of resources extracted through the times are in today’s built environment, with only an estimated 20-30% of building material recycled or reused and the sector accounting for over 35% of the EU’s total waste generation. Buildings are also responsible for 25-40% of all global carbon dioxide emissions. Circular Economy (CE) refers to the better management of resources and waste by closi
One of the most popular estimators of interactive effects panel data models is the common correlated effects (CCE) approach, which uses the cross-sectional averages of the observables to estimate the unobserved factors. The present paper proposes a simple test statistic that is suitable for testing hypotheses about these factors. The statistic can be used to test if a subset of the averages is eno
This paper considers a model with general regressors and unobservable common factors. An estimator based on iterated principal component analysis is proposed, which is shown to be not only asymptotically normal, but under certain conditions also free of the otherwise so common asymptotic incidental parameters bias. Interestingly, the conditions required to achieve unbiasedness become weaker the st
This article addresses the role of the corporate purpose in strategic financial communication from the perspective of investor relations officers (IROs) with particular reference to their sensemaking process. Strategic financial communication increasingly includes intangible assets that contribute to the value of the company. At the same time, more and more companies are publishing corporate purpo
Protein aggregates are a hallmark of Alzheimer's disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What happens to Bax if it fails to target mitochondria? We previously showed that a mitochondrial target-d
This article analyzes the utilization of the concept “Gnosticism” in a form of Satanism that has come to be known as “Chaos Gnosticism,” or “Gnostic Satanism.” The topic of the study is the Swedish expressions of this phenomenon attached to Current 218 and the Temple of Black Light, previously named the Misanthropic Luciferian Order (MLO). The group is known as one of the more radical and violent This article analyzes the utilization of the concept “Gnosticism” in a form of Satanism that has come to be known as “Chaos Gnosticism,” or “Gnostic Satanism.” The topic of the study is the Swedish expression of this phenomenon attached to Current 218 and the Temple of Black Light, previously named the Misanthropic Luciferian Order (MLO). The group is known as one of the more radical and violent f
