Filtyp
STUDY QUESTION Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? SUMMARY ANSWER Single-cell transcriptomic analysis reveals that only undifferentiated spermatogonia are present in prepubertal boys, while differentiated states emerge during puberty, w
Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 c
We analyze and compare the structure of two tables, the tables of al-Khwārizmī and George Peurbach’s Tabulae Eclypsium, looking at the syzygy angular velocities of the Sun and the Moon and the angular radii of the Sun, the Moon and the lunar eclipse umbra. We show that part of the underlying structure has a mediaeval Indian origin. Finally, we compare recomputed tables with Peurbach’s tables.
The growing use of 5G networks for critical services makes them vulnerable to Distributed Denial of Service (DDoS) attacks. While numerous Machine Learning (ML)-based approaches have been proposed, the real-world deployability of these models remains understudied. This work presents what is, based on existing literature, the first simulation-driven methodology to evaluate both the transferability
INTRODUCTION: Survival and healthcare for patients with congenital heart disease have improved, and the number of pregnancies among women of childbearing age with congenital heart disease has increased. Our aim was to investigate obstetric outcomes in a large retrospective, national registry study of women with congenital heart disease compared to controls.MATERIAL AND METHODS: The study included
Mechanisms of the aerosol indirect effects (AIEs) from ice nucleating particles (INPs) are investigated with the cloud-resolving “aerosol–cloud” (AC) model with a hybrid bin–bulk microphysics scheme coupled with a radiation scheme in 1) continental deep convection observed during the Midlatitude Continental Convective Clouds Experiment (MC3E) over Oklahoma and 2) supercooled stratiform clouds obse
In both second language acquisition research and teaching, there is a need for practical, reliable and valid proficiency tests to be used with learners of various target languages and at different proficiency levels. In the present study, a written proficiency test based on the C-test methodology was developed and tested on 144 Swedish 15-year-olds studying French, German, and Spanish in lower sec
I år är det 30 år sedan Sverige blev medlem i EU. Därmed är det också 30 år sedan Sverige anslöt sig till EU:s två språkpolitiska mål om lärande av främmande språk och skydd av minoritets- och regionalspråk. Det kan emellertid konstateras att dessa båda mål gått olika öden till mötes i Sverige. Medan minoritetsspråkens ställning har stärkts har hållningen kring främmande språk varit vacklande. Ett
Symmetric informationally complete measurements are both important building blocks in many quantum information protocols and the seminal example of a generalized, non-orthogonal, and quantum measurement. In higher-dimensional systems, these measurements become both increasingly interesting and increasingly complex to implement. Here, we demonstrate an integrated quantum photonic platform, operatin
Boreal forests are globally important carbon (C) sinks, but strategies for maximising their climate benefit remain under debate. Major uncertainties in this discussion arise from contrasting sink-source estimates, which largely emanate from inherent limitations of standard measurement techniques to distinct spatio-temporal scales. Here, we use a spatially-nested measurement framework that integrat
BACKGROUND: Prediction models for sentinel lymph node (SLN) status could potentially substitute surgical axillary staging in patients with early breast cancer. Several imaging modalities have been used with various feature extraction and selection approaches. This systematic review and meta-analysis aimed to evaluate prediction models for SLN status based on breast imaging in patients with early b
Changes in pupil size can lead to apparent gaze shifts in data recorded with video-based eye trackers in the absence of physical eye rotation. This is known as the pupil-size artifact (PSA). While the PSA is widely reported in desktop eye trackers, it is unknown whether and to what extent it occurs in head-mounted eye trackers. In this paper, we examined the effects of pupil size variations on eye
Acute myeloid leukemia is a genetically and cellularly heterogeneous disease. We characterize 120 AMLs using genomic and transcriptomic analyses, including single-cell RNA sequencing. Our results reveal an extensive cellular heterogeneity that distorts the bulk transcriptomic profiles. Selective examination of the transcriptional signatures of >90,000 immature AML cells identifies four main cluste
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
BackgroundAmbulance clinicians regularly encounter medical, caring, existential and ethical challenges. Meeting patients with complex medical presentations underscore the need for holistic decision-making and actions as ambulance clinicians struggle to strike a balance between addressing medical and caring needs.AimThis study aimed to explore action alternatives considered and discussed during eth
Vacuum membrane distillation is a promising technology for seawater desalination, as it enables high recovery ratios, with reasonable thermal and minimal electric consumption. Ceramic membranes can offer notable advantages over polymeric membranes, mainly due to their robust thermal and mechanical stability, yet they have limited representation in the literature. Accordingly, this work investigate
In this article, we argue for the value of student podcasts for fostering dialogue around questions of poetry and sustainable futures in an English as a foreign language context. Our research draws on our experiences of inviting student teachers to create their own podcasts on a recently published poem about nature or the Anthropocene, or both, in our first-year literature course for those studyin
Lon Fuller famously argued that polycentric issues are not readily amenable to binary and adversarial forms of adjudication. When it comes to resource allocations involving various interested parties, binary polemical forms of decision making may fail to capture the polycentric nature of the dispute, namely the fact that an advantage conferred to one party invariably involves (detrimentally) affec
In the wake of sustainability challenges and geopolitical tensions, the circular economy and x-shoring have received increasing attention as possible solutions or models for future development. Both concepts have an important geographic dimension and share other features such as foci on resilience and security. In this article, we elaborate on the two concepts and explore common drivers, potential
