Filtyp
The liver is a central metabolic hub, performing vital functions such as bile production, protein, carbohydrate, lipid and drug metabolism, detoxification of xenobiotics, and the synthesis of essential biomolecules for reproduction, and also shows regenerative capability. Several of these functions can be affected by sexual dimorphisms with important consequences. In this study we used high-throug
The use of Earth Observation Data and Machine Learning models to generate gridded micro-level poverty maps has increased in recent years, with several high-profile publications. producing some compelling results. Poverty alleviation remains one of the most critical global challenges. Earth Observation (EO) technologies represent a promising avenue to enhance our ability to address poverty through
Ulnar nerve entrapment at the elbow (UNE) is the second most common compression neuropathy in the upper limb. Immediate return-to-work (RTW) after surgery is seldom possible due to restrictions and recovery demands. We aimed to explore RTW after UNE surgery and investigate factors contributing to variations. A prospective study with patients undergoing primary UNE surgery was conducted. Treatment
The pattern of substitutions at sites in proteins provides invaluable information about their biophysical and functional importance and what selection pressures are acting at individual sites. Amino acid site rates are typically estimated using phenomenological models where sequence variability is described by rate factors that scale the overall substitution rate in a protein to sites. In this stu
We resolve the multiple images of the binary-lens microlensing event ASASSN-22av using the GRAVITY instrument of the Very Large Telescope Interferometer (VLTI). The light curves show weak binary-lens perturbations, complicating the analysis, but the joint modeling with the VLTI data breaks several degeneracies, arriving at a strongly favored solution. Thanks to precise measurements of the angular
Hybrid perovskites are interesting optoelectronic materials. The perovskite ABX3 structure offers a vast compositional space, and we have identified over 300 perovskite ions. This flexibility enables tuneable properties and has significantly contributed to the success of perovskite optoelectronics. However, this diversity also leads to confusion, ambiguity, and inconsistencies causing challenges f
Peripheral nerve tumours, most commonly schwannomas and neurofibromas, might present significant challenges by eliciting physical symptoms and emotional distress. We aimed to explore patients’ expectations, perceptions, and experiences regarding their diagnosis and the surgical treatment of a nerve tumour in the upper limb. Fourteen adults (10 women, 4 men; age range 35–85) from two Swedish hand s
Context. Hot Jupiters (HJs) with close-by planetary companions are rare, with only a handful of them having been discovered so far. This could be due to their suggested dynamical histories, which lead to the possible ejection of other planets. TOI-2109 b is special in this regard because it is the HJ with the closest relative separation from its host star, being separated by less than 2.3 stellar
För att minska och försöka eliminera utsläppen av koldioxid från byggsektorn krävs alternativ till dagens metod att skapa önskad funktion genom att riva befintliga byggnader följt av nyproduktion. Nyproduktion av byggnader medför stora klimatbelastande utsläpp kopplade till framställning av nya produkter och material, men även kopplat till rivnings- och nybyggnadsprocessen. Samtidigt är en del av Decarbonisation of the built environment requires alternatives to the prevailing practice of demolition followed by new construction. The new production of buildings adds upfront embodied emissions, while much of the non-residential stock remains underutilised, and housing demand remains high. Adaptive reuse, the practice of converting existing buildings for new functions, preserves the building's
Background: Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality. Aim: To develop a machine learning (ML) model to predict 30-day mortality in patients with diabetes admitted to the emergency department (ED). Design and setting: A cohort study utilizing data from all nine ED’s
Being one of the largest industries, the agricultural sector is central to achieving EU and UN sustainability goals. However, the role of sustainable business model innovation (SBMI) in low-tech sectors, such as agriculture, remains empirically underexplored, as existing research has largely focused on high-tech industries and large firms. The paper addresses this gap by examining how SBMI can sup
Targeted radionuclide therapy is an emerging potent therapeutic strategy in oncology. The cell surface antigen CD44v6 is a potential pan-cancer target for radionuclide therapy. This study aimed to evaluate the therapeutic efficacy, biodistribution, dosimetry, and safety profile of AKIR001, an antibody targeting CD44v6 labeled with 177Lu. Methods: The biodistribution and preclinical dosimetry of [1
BACKGROUND: Group 5 allergens, such as Phl p 5 of timothy grass, are major contributors to grass pollen allergy. Antibody 212597 specific for this allergen was recently isolated by single cell sequencing of bone marrow B cells of a grass pollen-allergic subject. This antibody, although subjected only to a low level of hypermutation resulting in six amino acid substitution across the heavy and ligh
Background: The Autism- Tics, ADHD and other Comorbidities inventory (A-TAC) has been validated in epidemiological data. However, validation against clinical diagnostic assessments in a population-based sample has been lacking, limiting the implications for clinical practice, clinical research and public health decisions. Methods: Study participants were recruited from the longitudinal Child and A
Chaperone proteins are essential for maintaining proteostasis. Their main role is to assist with the folding of other proteins and to prevent the aggregation of misfolded proteins. The molecular chaperone DNAJB6b efficiently suppresses amyloid formation of several peptides. This activity may rely on the same physicochemical properties as those driving chaperone self-assembly into large micellar-li
Background: Pneumocystis jirovecii pneumonia (PCP) is a severe opportunistic infection affecting immunocompromised patients. Quantitative polymerase chain reaction (qPCR) is widely used for the detection of P. jirovecii in respiratory samples. However, the diagnosis of PCP remains challenging and the high prevalence of P. jirovecii airway colonisation complicates the interpretation of positive res
Background: Cystic fibrosis (CF)-related diabetes (CFRD) is the most common extrapulmonary complication in CF. CFRD is associated with low lung function, but the underlying mechanisms are poorly understood. The aim of the present study was to compare airway inflammation and the airway proteome in people with CF (pwCF) with and without CFRD.Methods: Sputum samples from pwCF were analysed for neutro
