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Lipases are vital in modifying lipid substrates across industries such as food, cosmetics, and pharmaceuticals. Among their features, fatty acid selectivity is particularly important for industrial applications. Rhizopus oryzae lipase (ROL) stands out for its high selectivity and broad applicability. In this study, we engineered single-residue variants of ROL by targeting Ala89 and Phe95 in its li
The ELEGANCE study (NCT05043103) is an ongoing, non-interventional registry study collecting real-world data on long-term efficacy, safety and patient-reported outcomes following treatment with levodopa–entacapone–carbidopa intestinal gel (LECIG) infusion. To explore the effect of LECIG on non-motor symptoms (NMS) in advanced Parkinson’s disease patients participating in the ELEGANCE study and usi
Ectomycorrhizal fungi are critical mediators of nitrogen acquisition in forest ecosystems, exhibiting variation in both host association and metabolic traits that mediate differential responses to forest nitrogen availability. However, how nitrogen acquisition strategies vary among closely related fungal species, how these patterns manifest in conifer-associated ECM fungi, and whether they persist
Background: Endometriosis can cause gastrointestinal symptoms that sometimes lead to incorrect diagnosis of irritable bowel syndrome (IBS). Receptors of thyroid-stimulating hormone (TSH) are found in the endometrium and are overexpressed in ectopic endometrium. The role of TSH receptors and thyroid hormones in the pathophysiology of endometriosis has therefore been discussed. No biomarker is avail
A central challenge in water electrolysis lies with the oxygen evolution reaction (OER) where the formation of molecular oxygen (O2) is hindered by the constraint of angular momentum conservation. While the reactants OH− or H2O are diamagnetic (DM), the O2 product has a paramagnetic (PM) triplet ground state, requiring a change in spin configuration when being formed. This constraint has prompted
Introduction: Different strategies in prophylaxis for haemophilia among countries may affect long-term outcome. Aim: The aim of this study is to compare joint health in persons with severe haemophilia (PwSH) between Sweden and Greece, based on different approaches on prophylaxis initiation and management. Methods: Data were extracted from the PedNet Registry, which collects patient data prospectiv
Breviates are anaerobic protists and among the closest unicellular relatives of animals and fungi, yet their ecology and metabolism remain poorly understood. In this thesis, I investigated the distribution, metabolic potential, and bacterial interactions of breviates in low-oxygen environments. Breviates rely on bacteria both as a food source and potentially as metabolic partners. Breviates are pr
Major Histocompatibility Complex (MHC) polymorphism is maintained by balancing selection through host-pathogen interactions and mate choice. MHC-based mate choice has been investigated across a wide range of vertebrates, and an established concept is that females should choose a mate with an MHC genotype that is dissimilar to her own to ensure high MHC divergence in her offspring. Here we present
Carbon Fibre-Reinforced Polymers (CFRP) are a fast growing market of high performance materials and components. Thermally induced damage during machining processes such as drilling or routing are among the limiting factors for product quality, yet accurate temperature measurement remains challenging. This study develops a methodology which combines machinable thermocouples and IR thermometry techn
The problem of evil is commonly regarded as one of the greatest intellectual obstacles to theistic faith. But this is on the assumption that faith requires belief. In contemporary analytical philosophy of religion, many question this assumption and argue that non-doxastic, or belief-less, faith is possible. In this paper, we consider how the evidential problem of evil affects non-doxastic faith. N
In this chapter, we discuss threats and emotions as drivers of affective polarization. We base our discussion on Social Identity Theory and Intergroup Threat Theory, with the basic idea that threats posed by other social groups strengthen intergroup differentiation. Drawing on intergroup threat theory, we argue that when individuals perceive an outgroup threatens the ingroup, they will react with
On religious fictionalism, the problem of evil becomes a problem about fictional inconsistency. How can the fiction contain both a perfectly good and omnipotent God, and a world full of suffering? Le Poidevin has presented three strategies a fictionalist might use to come to terms with the problem: to edit the fiction, to let the fiction remain open, and to let the fiction be paradoxical. In my vi
Background and objective: The impact of a smoking and alcohol cessation intervention on health-related quality of life (HRQoL) following radical cystectomy (RC) is unclear. This study aimed to evaluate the effect of a 6-wk perioperative smoking and/or alcohol cessation intervention on HRQoL. A secondary objective was to assess the difference in HRQoL between patients with more than two and those w
The IPUMS Multigenerational Longitudinal Panel (MLP) is a longitudinal population panel that links American censuses, surveys, administrative sources, and vital records spanning the period from 1850 to the present. This article explains the rationale for IPUMS MLP, outlines the design of the infrastructure, and describes the linking methods used to construct the panel. We then detail our plans for
Introduction: Strategies for tuberculosis (TB) elimination in low-incidence countries involve screening recent migrants from TB-endemic regions for TB infection (TBI) and providing TB preventive treatment (TPT) to individuals with an increased risk of reactivation. This study aimed to determine TB incidence and identify reactivation risk markers in a cohort of asylum seekers in Sweden after screen
Background: Kidney transplant recipients after kidney transplantation may develop transplant renal artery stenosis (TRAS). Multiple studies have sought to identify risk factors, yet the findings remain inconsistent. Methods: PubMed, Scopus, and Web of Science Core Collection were comprehensively searched to retrieve studies. The 1st screening phase required studies to be in English and evaluate pa
Based on extraterrestrial chromite grains (63–355 μm) in late Eocene sediments, the Chesapeake Bay impact crater (northeastern United States; 40–85 km diameter) likely formed from an H-chondritic projectile. This impact occurred 10–20 k.y. after the formation of the Popigai crater (Siberia, Russia; ∼100 km). The craters formed at the peak of a 2-m.y. period with a factor of 3–5 enhanced flux of 3H
