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Cancer detection is challenging, especially in patients with diffuse symptoms that overlap with non-malignant conditions. Here we show that plasma protein profiling can identify cancer among patients with non-specific symptoms. Using proximity extension assay-based proteomics of 1463 plasma proteins from 456 patients presenting with non-specific symptoms sampled prior to cancer diagnostic work-up
Capturing fast transient spray phenomena, such as droplet breakup and secondary atomization, requires both high temporal and spatial resolution over extended durations, which is difficult to achieve with existing imaging methods. Burst imaging on one hand offers ultra-high frame rates but for short windows in time, while conventional high-speed cameras extend duration but are currently unable to t
Neural simulation-based inference (NSBI) is a powerful class of machine-learning-based methods for statistical inference that naturally handles high-dimensional parameter estimation without the need to bin data into low-dimensional summary histograms. Such methods are promising for a range of measurements, including at the Large Hadron Collider, where no single observable may be optimal to scan ov
Why are some regions rich and others poor? This study investigates the geographical origins of Italy’s persistent regional income gap. Using municipal population density as both a proxy for historical income and an outcome shaped by geography, we show that first-nature advantages, such as mild climates and fertile soils, predict higher population density in Northern Italy from the earliest availab
The present study aimed to increase understanding of how singing activities may be initiated in primary school, and what support and assistance teachers require to conduct singing activities as an integrated part of the school day. Five music teachers participated in a focus group interview. The following main themes were identified: 1) pedagogical and methodological flexibility, 2) the role of ro
Understanding the genetic regulation of blood CD34+ cell levels could lead to better methods for stem cell mobilization and transplantation. Recently, in a genome-wide association study (GWAS), we identified 11 genetic associations with blood CD34+ cell levels. One of the most significant maps to an intergenic region between the ENO1 and RERE genes at chromosome 1p36.23. However, the underlying me
Discontinuous Galerkin (DG) methods are promising high order discretizations for unsteady compressible flows. Here, we focus on Numerical Weather Prediction (NWP). These flows are characterized by a fine resolution in z-direction and low Mach numbers, making the system stiff. Thus, implicit time integration is required and for this a fast, highly parallel, low-memory iterative solver for the resul
The transition to a circular economy has placed growing pressure on packaging systems to enable effective material recovery across increasingly complex waste and recycling infrastructures. Focus on aggregate recycling rates obscure the stage- specific inefficiencies that determine whether packaging material re- enters production, making it difficult to target packaging design efforts, infrastruc
ObjectivesLong COVID, defined as diverse symptoms persisting > 3 months post-infection, remains a major post-pandemic healthcare burden. Here we investigate risk factor posed by pre-existing respiratory symptoms and illnesses for development of long COVID, with focus on individuals with mild-to-moderate COVID-19 at the primary infection, that did not require hospitalization during the primary SARS
This article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingraiThis article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingrai
A less studied aspect in research on globalisation and outsourced production is how work in the global value chain is infused with precarity and may even become a space of harassment and violence, including sexual abuse. This themed section seeks to contribute to the literature on gender-based violence in factories where production has been outsourced to the Global South, especially Asia. In this
This study explored how final-year psychology students experienced their initial exposure to virtual reality (VR) relaxation using a scientifically developed application designed to promote emotional well-being and stress reduction. The aim was to understand how VR is perceived as a space for emotional regulation, embodiment, and reflection within psychological education. A qualitative exploratory
Mojtaba Khamenei’s rise to Iran’s supreme leadership represents the consolidation of dynastic power within the Islamic Republic. Long operating behind the scenes through the Supreme Leader’s office and the Islamic Revolutionary Guards, he has been widely viewed as the most likely successor to his father. His leadership signals continuity with the regime’s totalitarian structure and suggests a furt
BACKGROUND: The Leiden group and the Assessment of Spondyloarthritis International Society (ASAS)-MRI study group have proposed definitions for structural (SL) and active (AL) lesions typical for axial spondyloarthritis (axSpA) on MRI of the sacroiliac joints (MRI-SIJ).OBJECTIVES: To analyse the predictive validity of proposed SL and AL MRI-SIJ definitions in early axSpA and compare proposed AL wi
INTRODUCTION: Ventilator-associated pneumonia (VAP) is the most frequent healthcare-associated infection in intensive care units and is associated with high morbidity and mortality. Current diagnostic criteria lack specificity, leading to misclassification and unnecessary antibiotic use. Identifying patient subgroups with a common pathophysiological basis (pneumoclusters) may distinguish true VAP
BACKGROUND: Pesticides play a crucial role in pest control; however, exposure remains high, particularly among smallholder farmers in low-income and middle-income countries (LMICs) with little access to pesticide safety training. This study aimed to provide comparative biomarker-based evidence from Latin America and Africa and identify actionable determinants of exposure to inform context-specific
Resisting obsessive-compulsive disorder (OCD) compulsions is a key predictor of exposure and response prevention (ERP) effectiveness, yet trauma-exposed individuals with OCD endorse more severe compulsions and are more likely to be labelled 'treatment resistant.' Among trauma-exposed individuals, compulsions are theorised to function to prevent future trauma and cope with trauma-related responses.
OBJECTIVE: To investigate a recently developed MRI technique for mapping the Mean Diffusivity of Tissue (MDT), which improves diffusion MRI imaging of the cerebral cortex by reducing partial volume effects from cerebrospinal fluid (CSF). As cortical lesions are common in patients with focal epilepsy, we explored the clinical value of MDT imaging in patients with drug resistant epilepsy and low-gra
