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Samverkande proteiner vid syrebrist under inflytande av inhibitorn PT2385 i hjärntumörceller från barn DIPG är en typ av hjärncancer hos barn som är placerad i övre delen av nacken vilket gör den svår att operera. Ledsamt nog finns ingen behandling för denna sjukdom, och patienter behandlas ofta med strålning för att förlänga livet med några enstaka månader. Hos den typiska patienten så överlevePurpose: The HIF-2α inhibitor PT2385 inhibits complex formation between HIF-2a and ARNT1 and thereby blocks HIF-2a transcriptional activation. It has been proven to extend survival in renal cancer, while its effects in pediatric brain cancer are unknown. This study is to investigate the effect of PT2385 in diffuse intrinsic pontine glioma (DIPG) cells, as well as to investigate HIF-2a interaction

Emotionellt arbete är ett begrepp som innebär den känsloreglering en individ gör för att leva upp till olika situationers förväntade beteenden och uttryck. Sker detta inom en yrkesroll så är det ett emotionellt lönearbete. Forskning har visat att denna känsloreglering, som innebär både att förstärka vissa känslor och förtrycka andra, kan vara skadligt för en individ som utövar detta under en längr

Investigating the Mechanism of Action of DNA Damage Response Inhibitors Cancer is a complex, heterogenous, systemic disease. It is considered to be a leading cause of death worldwide. Currently, there is limited treatment for this disease and the field of oncology presents the highest percentage of failed trials (32%) for drugs in phase II and phase III, mainly due to lack of efficacy or safety.

Glucose transporters, known as Gluts, play an important role in facilitating the transport of sugar across the cell membrane. Of these, 14 types are known, one of which is Glut3, which is highly expressed in the brain, testicles and nervous system. Its importance lies in the fact that it is responsible for the uptake of glucose in cells with high sugar requirements, such as neurons. Glucose uptake

Cracking the Code: Why Cancer Cells Struggle to Transform into Antigen-Presenting Dendritic Cells Since cancer is one of the leading causes of death worldwide, the possibility of converting cancer cells into other cell types represents an interesting approach to fighting cancer. Transforming cancer cells into immune cells by reprogramming their cell identity into immune cells could be a smart way

Rökextrakt och dess negativa påverkan på återvinningsprocesser i lungceller från KOL-patienter Kroniskt obstruktiv lungsjukdom (KOL) är en global folksjukdom och den tredje största dödsorsaken i världen. Den kan kopplas till en mängd andra sjukdomar och tillstånd som också ofta ökar risken för att utveckla KOL, t ex hög ålder, kardiovaskulära och neurosjukdomar. Men den största och mest välkända Chronic obstructive pulmonary disease (COPD) is the third largest cause of death worldwide, with its most prominent risk factor being inhalation of smoke and pollutants. In this project, we studied two processes that are involved in COPD: autophagy and cellular senescence. Using primary human bronchial epithelial cells (HBECs) from healthy and COPD donors, we aimed to show that cigarette smoke ext

Våra celler kommer ihåg SARS-CoV-2 Hjärt- och kärlsjukdomar är en av de ledande dödsorsakerna i världen. Ateroskleros, ett tillstånd där fett ansamlas i kärlen, har visats orsaka hjärt- och kärlsjukdomar. Flera delar av vårt immunförsvar har även visats ha ett samband med ateroskleros. En av dessa delar är det adaptiva immunförsvaret, där så kallade B- och T-celler finns. B- och T-celler ingår iAdaptive immunity has been implicated in cardiovascular diseases, but the relationship between immune capacity or immune function in these diseases has yet to be established. I optimized a method to screen for immune capacity using immune responsiveness against the SARS-CoV-2 spike protein as a proxy. This method screens for markers upregulated during activation on lymphocytes using fluorescent an

Pneumonia is a common infectious disease of the lungs. When the lung tissue becomes inflamed, it can lead to symptoms such as cough, fever, and difficulty breathing. The most common cause of pneumonia is the bacterial species Streptococcus pneumoniae, also known as pneumococcus. This species is sometimes found in cultures from the nose or throat, without causing disease. If the immune system is we

The purpose of this paper has been to study whether or not the Swedish language has any significant impact on immigrant integration and their psychic well-being in Swedish society. By adhering to the theoretical framework of Diaz, Gordon, and Heckmann for integration, and Antonovsky’s theory of salutogenesis, we’ve established our results using qualitative semi-structured interviews to get our emp

Given the importance of copper prices to investors, governments, and policymakers, this paper investigates short-term price predictability using VAR and XGBoost models. All models are trained with historical data from November 2021 to December 2022 and using MSE, RMSE and MAE for evaluating the model performance. The results show that the XGBoost model outperforms VAR models, implying that machine

With Russia becoming increasingly hostile towards the West with the culmination of the full-scale invasion into Ukraine in February of 2022, the rhetoric of Putin has been linked to the philosophy of a geopolitically aggressive right-wing sociologist called Alexander Dugin. With several previous statements pertaining to the delegitimization of the sovereignty of Europe Dugin has previously argued

The banking and financial services industry is experiencing a significant transformation driven by factors such as regulatory changes, customer demands, and the growing focus on data. This evolution has given rise to the concept of open finance, an extension of open banking that encompasses various financial sectors. Open finance aims to promote data sharing and access across the industry, with th

Situated in the context of the global rise of the right and growing anti-feminist and anti-gender mobilization, this thesis explores the impacts of Jair Bolsonaro's right-wing populist government (2019-2022) on feminist activism in Brazil from an activist's perspective. It investigates the shifts and disruptions this government has entailed on three levels: in the realms of social public p

The primary aim of this study has been to examine to what extent people with addiction experience feelings of loss and sorrow as they go from being active in their abuse, to being an addict in recovery. The study is based on life stories generated from semi-structured, qualitative interviews, meaning the results are built on the voices of 6 people who are all recovering addicts. The complex emotio

According to the Swedish Care of Young Persons Act (LVU), rulings regarding compulsory care should be independent of aspects of gender, ethnicity, or social background. This paper aims to examine on what grounds youths are taken into compulsory care according to the prerequisite “other socially destructive behavior” stated in 3 § LVU. Meanwhile, how administrative courts apply the concept of the c

As the number of displaced people is increasing globally, host countries are experiencing difficulties in keeping up with the increasing demands of their growing population. But who is paying the highest price? Through a qualitative approach, this research aims to study the refugee response to Wash, Sanitation, and Hygiene (WASH) as well as Menstrual Hygiene Management (MHM) and how the needs of w

Sweden has long been seen as a generous, inclusive provider for refugees, historically granting social rights on par with citizens shortly upon arrival. However, extensive recent academic literature has come to critique this perception, highlighting retrenchments and restrictive developments in asylum policy amid increasing precarity for asylum seekers. Studies have also documented mental health v

The purpose of this thesis is to study how human mobility in the context of climate and environmental change is governed at a regional level in Southeast Asia, with the regional intergovernmental organisation ASEAN, as a case study. Through a policy review of ASEAN policies on climate, migration, disaster risk reduction and development this study finds that the climate-environment-mobility nexus i

Exit strategies constitute a pivotal moment of humanitarian action and greatly determine the sustainability of programmes’ outcomes. Despite their significance, they are often rushed and fail to consider the impact on aid recipients. This thesis aims to examine the exit strategies’ aspirations of four international organizations providing humanitarian health assistance through the lens of accounta