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Pathogenic germline TP53 variants predispose to a wide range of early onset cancers, often recognized as the Li-Fraumeni syndrome (LFS). They are also identified in 1% of families with hereditary breast cancer (HrBC) that do not fulfill the criteria for LFS. In this study, we present a total of 24 different TP53 variants identified in 31 Swedish families with LFS or HrBC. Ten of these variants, ni
Sophisticated IrO2(110)-based model electrodes are prepared by deposition of a 10 nm thick single-crystalline IrO2(110) layer supported on a structure-directing RuO2(110)/Ru(0001) template, exposing a regular array of mesoscopic rooflike structures. With this model electrode together with the dedicated in situ synchrotron based techniques (SXRD, XRR) and ex situ characterization techniques (SEM, T
Background: Incidental gallbladder cancer is a rare event, and its prognosis is largely affected by the tumour stage and treatment. The aim of this study was to analyse the management, treatment and survival of patients with incidental gallbladder cancer in a national cohort over a decade. Methods: Patients were identified through the Swedish Registry of Gallstone Surgery (GallRiks). Data were cro
Maternal lifestyle during pregnancy, as well as early nutrition and the environment infants are raised in, are considered relevant factors for the prevention of childhood obesity. Several models are available for the prediction of childhood overweight and obesity, yet most have not been externally validated. Moreover, the factors considered in the models differ among studies as the outcomes manife
How do mainstream political executives cue their politicised constituencies on European integration? Moving beyond static expectations that EU politicisation induces executives to either undermine, defuse or defend integration, this article theorises executives’ incentives under different configurations of public and partisan Euroscepticism in their home countries. Expectations are tested on the s
Purpose: To demonstrate the feasibility of multidimensional diffusion MRI to probe and quantify microscopic fractional anisotropy (µFA) in human kidneys in vivo. Methods: Linear tensor encoded (LTE) and spherical tensor encoded (STE) renal diffusion MRI scans were performed in 10 healthy volunteers. Respiratory triggering and image registration were used to minimize motion artefacts during the acq
Background and purpose — The incidence of manipulation under anesthesia (MUA) after knee arthroplasty surgery has been reported to vary between 0.5% and 10%. We evaluated the incidence of MUA after primary knee arthroplasty in Sweden, the demographics of the patients and the risk of revision. Patients and methods — Between 2009 and 2013, 64,840 primary total and unicompartmental knee arthroplastie
Unlike much of the contemporary discussion of embodiment, phenomenology is really involved with the body as a kind of meaning appearing to consciousness; and it does not only attend to the body of the biological organism, but also to the kind of organism-independent artefacts which are required by some sign systems. Because it is concerned with meaning, phenomenology is akin to semiotics. From the
Label: Proprius PRCD 2083
Label: Proprius PRCD 2084
Label: Caprice CAP 21735
Label Euterpe Musica EMCD 1316
