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Parkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by a progressive loss of dopaminergic neurons (DNs) in substantia nigra pars compact and accumulation of aggregated forms of the protein α-synuclein known as Lewy Bodies (LBs). LBs are present in surviving DNs and other regions of the central nervous system (CNS) in PD patients. PD patients also disp
The whole word has been getting somewhat familiar with the crisis that the newspaper industry has been experiencing. The past decade has seen print mainly absorbing finances with little to no profits, and the ever-growing digital not offering enough advertising revenue. Hence, the challenges managers face becomes clear: how can we innovate effectively when the current system is a loophole? Additio
Biological drugs such as tumor necrosis factor (TNFα) blockers are very successful and effective in therapy of chronic inflammatory disease. These blockers bind TNFα and inhibit its pro-inflammatory function. But unfortunately, biological drugs are immunogenic and prolonged treatment triggers the formation of anti-drug antibodies and neutralizing antibodies (NAbs). This reaction is associated with
The fast food industry is one of the important and growing segments of the overall restaurant industry. At the same time, it is a very dynamic and competitive business where too many vendors are chasing too few clients.To maintain sustainable growth and long-term success it is crucial to meet consumer needs and offer value to them. In order to achieve this, fast food providers must first evaluate
This research study aims to examine why small business owners comply with rules and regulations within their industries. The purpose is to obtain a deeper understanding of legal obedience amongst small business owners. More specifically, what extrinsic and intrinsic motivations makes small business owners comply with the laws. This study is exploratory and is based on five semi-structured intervi
The purpose of this project was to gain knowledge of polyhydroxyalkanoates’ (PHAs’) ability to be fractionated and form miscible blends for different structures, by using the methods: solvent/non solvent fractionation and co-dissolving in 2-butanol.The outcome of the fractions and blends was evaluated with differential scanning calorimetry (DSC), size exclusion chromatography (SEC), Fourier transf
This bachelor thesis was performed at BorgWarner AB in Landskrona. The assignment was to investigate different methods for external measurement of a permanent magnetized DC motor speed in revolutions per minute when you have no access to the rotor. The task was to examine different measurement methods, to produce a finished circuit that converts the signal frequency to rpm and build a complete too
Building new wind farms is an important part in the transition to renewable energy. However these projects often require large investments, and the cost of upgrading the existing infrastructure - to allow for the connection of new parks - is a component that cannot be ignored. When several wind farms seek interconnections, they are forced to collaborate and financing the connection. This leads to
After the introduction of a conjugate vaccine that provides immunization to Haemophilus influenzae type b, an increase in the number of infections caused by Non-typeable H. influenzae (NTHi) has been reported. NTHi mostly affects children under the age of 1, causing cases of otitis media and conjunctivitis, and it is also associated with respiratory tract infections such as exacerbations of chroni
The CRISPR-Cas9 system for genetic engineering has recently emerged as promising tool for studying gene functions in a variety of systems and organisms. Here, we are particularly interested in studying the role of DGCR8 in a human neuroepithelial-like stem (hNES) cell line. Beyond its characterized role in the microRNA biogenesis pathway, recent studies have implicated the enzyme’s involvement in
