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Background Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. Objective To evaluate
Background ODM-201, a new-generation androgen receptor inhibitor, has shown clinical efficacy in prostate cancer (PCa). Quantitative methods are needed to accurately assess changes in bone as a measurement of treatment response. The Bone Scan Index (BSI) reflects the percentage of skeletal mass a given tumour affects. Objective To evaluate the predictive value of the BSI in metastatic castration-r
Aim: Clinical seizures are common after cardiac arrest and predictive of a poor neurological outcome. Seizures may be myoclonic, tonic-clonic or a combination of seizure types. This study reports the incidence and prognostic significance of clinical seizures in the target temperature management (TTM) after cardiac arrest trial. Our hypotheses were that seizures are associated with a poor prognosis
The concept of genre is scrutinized as a semantic phenomenon, and it is argued that the concept of genre must be defined according to a pragmatic semantic, not a realistic. Genres are not logical classes. The analytic practice is then connected to this way of defining the concepts: it is governed by how the culture using the concept understands the word. An analysis of a letter of Mme de Sévigné d
Hydrophobins are small secreted proteins that are present as several gene copies in most fungal genomes. Their properties are now well understood: they are amphiphilic and assemble at hydrophilic/hydrophobic interfaces. However, their physiological functions remain largely unexplored, especially within mycorrhizal fungi. In this study, we identified hydrophobin genes and analysed their distributio
Sex ratio variation is commonly observed in natural populations of many organisms with separate sexes and genetic sex determination, including bryophytes. Most bryophyte populations exhibit female-skewed expressed adult sex ratios, generally inferred from counts of sexually mature plants. For the rarely sexually reproducing perennial dioicous moss Drepanocladus lycopodioides, we showed that a fema
This paper presents an adaptive video encoder that can be used to compare the behavior of different adaptation strategies using multiple actuators to steer the encoder towards a global goal, composed of multiple conflicting objectives. A video camera produces frames that the encoder manipulates with the objective of matching some space requirement to fit a given communication channel. A second obj
Tunnel FETs (TFETs) have been identified as the most promising steep slope devices for ultralow power logic circuits. In this paper, we demonstrate in-plane InAs/Si TFETs monolithically integrated on Si, using our recently developed template-assisted selective epitaxy approach. These devices represent some of the most scaled TFETs with dimensions of less than 30 nm, combined with excellent aggrega
Self-adaptation provides a principled way to deal with change during operation. As more systems with strict goals require self-adaptation, the need for guarantees in self-adaptive systems is becoming a high-priority concern. Designing adaptive software using principles from control theory has been identified as one of the approaches to provide guarantees. However, current solutions can only handle
Background: The fractalkine/CX3C chemokine receptor 1 (CX3CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also been shown to be important in the regulation of the inflammatory response in the early phase after experimental stroke. The present study was performed to investigate if CX3CR1 de
We report on the influence of doping on the band-edge abruptness of InAs/GaSb p-n and p-i-n tunnel diodes. Understanding and fabrication of a well-defined and sharp band edge is mandatory for tunnel FET operation. InAs/GaSb nanowire junctions were selectively grown by metal organic chemical vapor deposition (MOCVD) on silicon-on-insulator (SOI) substrates using template assisted selective epitaxy
We demonstrate for the first time a technology which allows the monolithic integration of both p-Type (InAs-Si) and n-Type (InAs-GaSb) heterojunction Tunnel FETs (TFET) laterally on a Si substrate. The lateral heterojunction nanowire (NW) structures are implemented using top-down CMOS-compatible processes combined with Template-Assisted Selective Epitaxy (TASE) [1] of the III-V materials. Sub-40nm
In this presentation we will discuss our recent progress on the integration of InAs/Si p-tunnel FETs (TFETs) and InAs/GaSb n-TFETs on SOI wafers. Local III-V growth is enabled by the development of Template-Assisted Selective Epitaxy (TASE) [1-4]. Both polarity devices have scaled geometries with cross-sections on the order of 30nm. The p-channel InAs/Si TFETs are developed based on our previously
This part of the paper presents TCAD simulations of the InAs/Si lateral nanowire (NW) tunnel FET (TFET) with the same geometry as the fabricated device discussed in the first part. In addition to band-to-band tunneling, trap-assisted tunneling (TAT) at the InAs/Si and InAs/oxide interfaces was considered. A very good agreement is found between the simulation results and experimental transfer chara
We report InAs-Si nanowire (NW) Tunnel FETs fabricated inside nanotube templates. High device yield and performances are obtained by optimizing the growth conditions and the fabrication flow using inorganic material as dielectric spacer, atomic-layer-deposition for the metal gate and by scaling the equivalent oxide thickness (EOT). We extract the exponential parameter B of Kane's tunneling model f
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of mesDA neuron development. Here, we studied this process using transcriptome-wide single-cell RNA sequencing of mouse neural progenitors expressing the
