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Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. Such diversity does not result from the malignant cells alone but a product of multitudeof complex interactions among the melanoma and non-melanoma cells in the tumor micr
Autoimmune limbic encephalitis is part of CASPR 2 antibody-associated disease. A man with this rare disorder and a very high antibody titre had a unique history of laboratory exposure to the antigen. Together with earlier observations this case calls for caution in laboratory handling of nerve tissue.
Viable city logistics are built on a sound business model that considers the financial viability and performance, and the role of externalities and stakeholders. To this end, the purpose of this dissertation is to increase understanding of how a business model can contribute to achieving viable city logistics initiatives.The research presented is qualitative and consists of three studies and five
AbstractThe building sector in Sweden and Europe is a major energy consumer, accounting for around 40% of total energy use. It is a challenge to optimize available technical and social strategies for the fragmented construction industry. Professionals such as architects and different building engineers play a crucial role in the technology adoption process.This study aims to contribute to the unde
Abstract Background: Dyspnea is a common manifestation of a range of conditions and diseases, sometimes with multiple contributing factors. A subgroup of these patients present with acute hypecapnic respiratory failure (AHRF) and are treated with non-invasive positive pressure ventilation (NPPV). Despite the biomarkers and clinical signs available to predict outcome in patients with respiratory fa
Background: Non-medical Prescription Opioid Use (NMPOU) has increased worldwide during the last decades, and specifically, tramadol misuse may represent a novel pattern of substance use among adolescents. The present study aims to analyze characteristics distinguishing tramadol-using adolescents from other substance-using adolescents seeking out-patient treatment. Methods: This is a cross-sectiona
Purpose: In addition to a breast density category, temporal changes in breast density have gained attention as a dynamic breast cancer risk marker. This case-control study aimed to investigate a potential change in breast density preceding tumor development and the relationship of this potential change to prognostic pathological tumor variables. Method: A total of 51 consecutive, eligible-for-anal
This study investigates how ascending movement is affected by carrying load during a stair‐climbing motion. The methods adopted are based on exercise physiology and fire safety engineering. Experiments with 21 volunteers with mean (SD) age of 27 (4) have been carried out on a stair machine with or without carrying a mass of 8 kg, typical weight of a hand luggage or the average weight of an 8‐month
The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Besides its antimicrobial properties, LL-37 modulates the innate immune system, and furthermore, i
Personal data is often the target of people who are not responsible for being misused. Theft is done to benefit from people who have the data. In addition to the theft of work files, theft is also carried out on video files. Theft of this file aims to find out what the contents of the video. Someone has a private recorded video that cannot be known by others. Misuse of video files will be fatal fo
Objective: To evaluate progression of individual radiographic features 5 years following exercise therapy or arthroscopic partial meniscectomy as treatment for degenerative meniscal tear. Design: Randomized controlled trial including 140 adults, aged 35–60 years, with a magnetic resonance image verified degenerative meniscal tear, and 96% without definite radiographic knee osteoarthritis. Particip
Objective: The incidence of urinary stones is increasing across the globe. Surgical treatment includes extracorporal shock-wave lithotripsy (ESWL), ureterolithotripsy (URS), percutaneous nephrolitotomy (PCNL) and rarely open surgery. This single center study describes complications to PCNL focusing on infections, bacterial growth/resistance and antibiotic prophylaxis/treatment. Materials and metho
This paper investigates the robustness of control systems when a controller is run in a Fog environment. Control systems in the Fog are introduced and a discussion regarding relevant faults is presented. A preliminary investigation of the robustness properties of a MinSeg case study is presented and commented. The discussion is then used to outline future lines of research.
Color information is an important tool for diagnosing melanoma. In this study, we used a hyper-spectral imager (HSI), which can measure color information in detail, to develop an automated melanoma diagnosis system. In recent years, the effectiveness of deep learning has become more widely accepted in the field of image recognition. We therefore integrated the deep convolutional neural network wit
Recent attempts by several big tech companies to create their own currencies, such as Facebook's Libra, have drawn attention to monetary innovations. The case offers important insights for this debate by engaging with the wave of monetary innovation and entrepreneurship triggered by the unemployment and economic distress of the Great Depression in the 1930s. Through the vantage point of one of the
The case is about today's crypto-activists' efforts to organise a cooperative global economic system that is an alternative to the State and to market capitalism. Through the vantage point of FairCoop, the reader gets an insight on the necessary elements needed to consider when organizing an economic system for the commons: a community that produces, a market in which products can be exchanged, an
The case is about the choice of governance structures for a community currency in the impoverished South of Spain that aims to alleviate the economic hardships brought by the economic crisis. The reader gets an insight into the economic contexts of these currencies, the functioning of one of its most common designs (mutual credit systems or LETS), as well as the governance structures of community
Terrestrial ecosystem gross primary productivity (GPP) is the largest land-atmosphere carbon flux and the primary mechanism of photosynthetic fixation of atmospheric CO2 into plant biomass. Anomalous rainfall events have been shown to have a great impact on the global carbon cycle. However, less is known about the impact of these events on GPP, especially in Africa, where in situ observations are
