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Objective. Although partial meniscectomy is a risk factor for the development of knee osteoarthritis (OA), there is a lack of evidence that meniscal damage that is not treated with surgery would also lead to OA, suggesting that surgery itself may cause joint damage. Furthermore, meniscal damage is common. The aim of this study was to evaluate the association between meniscal damage in knees withou
This thesis deals with the hunting of wild boar during the Mesolithic in South Scandinavia and the relationship between humans and wild game. The study is based on an analysis of osteological remains from sites in Scania, Sweden, dating from the Late Maglemose Culture to the Early Ertebølle Culture. Tooth development and tooth wear in recent populations from Poland, Germany and Sweden have been s
We extend the algorithm for matching fixed-order tree-level matrix element generators with the Dipole Cascade Model in Ariadne to apply to processes with incoming hadrons. We test the algoritm on for the process W+n jets at the Tevatron, and find that the results are fairly insensitive to the cutoff used to regularize the soft and collinear divergencies in the tree-level matrix elements. We also i
Objective. To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort of systemic lupus erythematosus (SLE) patients. Methods. The study was conducted by the Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months of fulfilling the American College of Rheumatolo
Two Late Jurassic successions from western Skåne were investigated with respect to clay mineral contents of mudstones. Although these resemble clay mineral suites from a third succession in Central Skåne, it is evident that different depositional areas show separate clay mineral trends with time, probably due to that detrital clay minerals were derived locally from heterogeneous weathered crystall
1H-[1,2,3]-Triazol-1-yl mannosides have been synthesized as inhibitors for the beta-galactoside-binding family of galectin proteins. Easier synthetic access to C1 in mannose, as compared to C3 in galactose, for attachment of affinity-enhancing triazoles rendered a synthetic advantage. The best mannose-derived inhibitor for galectin-9N, 4-benzylaminocarbonyl-1H-[1,2,3]-triazol-1-yl beta-D-mannopyra
A number of failures have recently occurred in glulam structures in the Scandinavian countries. This paper analyses and discusses two of these failures: Two recently built glulam roof structures with spans of about 75 and 55 m that failed under low loading conditions. Gross error in the design was found to be the main cause in one case, but other potential failure causes were identified and analys
The tryptophan (W) repressor-binding proteins (WrbA) from Escherichia coli (EcWrbA) and Archaeoglobus fulgidus (AfWrbA) were investigated for possible use in 1,4-dihydronicotinamide adenine dinucleotide (NADH) dependent amperometric biosensors and biofuel cells. EcWrbA and AfWrbA are oligomeric flavoproteins binding one flavin mononucleotide (FMN) per monomer and belonging to a new family of NAD(P
SELDI-TOF MS is a mass spectrometric technique which has been extensively used for biomarker discovery. In this study, we show that in-source decay is an important source for the generation of additional spectral peaks with this technique, both for pure proteins and proteins in serum samples. Thus, SELDI-TOF MS could be used to gain sequence information from proteins, but the results also question
We prove that any connected 2-compact group is classified by its 2-adic root datum, and in particular the exotic 2-compact group DI(4), constructed by Dwyer-Wilkerson, is the only simple 2-compact group not arising as the 2-completion of a compact connected Lie group. Combined with our earlier work with Møller and Viruel for p odd, this establishes the full classification of p-compact groups, stat
The cyp102A2 and cyp102A3 genes encoding the two Bacillus subtilis homologues (CYP102A2 and CYP102A3) of flavocytochrome P450 BM3 (CYP102A1) from Bacillus megaterium have been cloned, expressed in Escherichia coli, purified, and characterized spectroscopically and enzymologically. Both enzymes contain heme, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) cofactors and bind a vari
Objective: To evaluate the effects of a single-session, interactive computer-based educational program on knowledge, compliance and quality of life in heart failure patients with special emphasis on gender differences. Methods: One hundred and fifty-four patients, mean age 70 years, from five heart failure clinics were randomised to either receiving only standard education (n = 72) or standard edu
Defects in the mitochondrial protein frataxin are responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1:40,000 children. Here, we present the crystal structures of the iron-free and iron-loaded frataxin trimers, and a single-particle electron microscopy reconstruction of a 24 subunit oligomer. The structures reveal fundamental aspects of the frataxin mechanism.
Type 2 diabetic patients are at increased risk to develop atherosclerotic vascular disease. These patients are often treated with sulphonylurea derivatives, and it has been suggested that this treatment might contribute to the increased atherosclerotic process. The aim of the present study was therefore to investigate whether tolbutamide influences lipid metabolism in such a way that the atheroscl
