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The downstream process of monoclonal antibodies (mAbs) is expensive and significantly contributes to overall manufacturing costs. One primary reason is the extensive consumption of water and chemicals required for preparing large volumes of various buffers, essential for multiple chromatography and filtration steps. Reducing the water consumption in biopharmaceutical processes is critical to drive
We update the HOMER method, a technique to solve a restricted version of the inverse problem of hadronization – extracting the Lund string fragmentation function f (z) from data using only observable information. Here, we demonstrate its utility by extracting f (z) from synthetic PYTHIA simulations using high-level observables constructed on an event-by-event basis, such as multiplicities and shap
Intolerance of uncertainty (IU), cognitive avoidance (CA), positive beliefs about worry (PBW) and a tendency to view everyday problems as threats, termed negative problem orientation (NPO), are cognitive vulnerabilities associated with symptoms of anxiety and depression in adults, with fewer studies examining all four vulnerabilities in youth. In this study, validated measures of IU, CA, PBW and N
Introduction: Doxorubicin (DOX), a potent anthracycline, is widely used in cancer therapy, but its effect is limited by doxorubicin-induced cardiotoxicity (DIC). Increasing evidence suggests that DIC is associated with ferroptosis, a cell death characterized by the iron-dependent accumulation of lipid peroxides. Although aerobic exercise is recommended for chemotherapy-related cardiac dysfunction,
Epilepsy is a prevalent neurological disorder characterized by spontaneous recurrent seizures (SRS). Epileptogenesis is a multifaceted pathophysiological process that transforms a normal brain into one prone to chronic seizures. Targeting epileptogenesis is a compelling line of epilepsy therapy. Thus, discovering new drugs that oppose, mitigate, or modify epileptogenesis is a significant challenge
The life of Jerome of Stridon (d. 419/420), who was regarded as a father of the church and one of the most important authorities in the Middle Ages, has often been depicted as highly controversial: In modern reconstructions, Jerome is typically described as an outsider, constantly involved in controversies and frequently criticized and questioned by his contemporaries. This begs the question of ho
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
The popularity of the Vikings and the Viking Age in Scandinavian history cultures never seems to fade. As a projection surface for meaning-making needs in the present, the Viking Age constantly finds new ways to mirror the present, thus voicing new history-cultural trends. However, the Vikings carry heavy history-cultural traditions that tend to lead them to being portrayed as national symbols and
In architecture and urban geography, discussions on repair, maintenance and adap5ve re-usehave emerged as a crucial intellectual terrain. Temporal aspects of how the urban fabric isused have also emerged as an issue worth theore5cal and empirical a=en5on. Latching ontothese themes, we will present work tracking the history of conten5on around the publiclyowned mee5ng and arts venue in Lund’s Peopl
Membrane bioreactor (MBR) has been recognized as an advanced water treatment technology to remove diverse impurities from various water resources (such as wastewater, surface water, groundwater, and rainwater). In MBRs, membrane separation and biodegradation are synergized to enhance pollutant removals in order to achieve treated water of superior quality. Pressure-driven microfiltration (MF)/ultr
Membrane Technology for Water Purification is a comprehensive guide arranged in three parts to enable the student and researcher learn about membrane technology and the most recent updates of material science to clean water of its pollutants. Membrane systems are finding increasing application worldwide in purification and the editors re lead experts in the field. The book contains real-life appli
Despite a flurry of critical analyses discussing its controversial track record in terms of effectiveness and social feasibility, carbon offsetting remains one of the key mechanisms within global climate governance. We address an understudied dimension of the offsetting paradigm, with a focus on the voluntary carbon market and nature-based ‘solutions’, to inquire whether carbon trading constitutes
Internalizing disorders (INTs), including anxiety (AD) and depressive disorders (DD), frequently emerge during adolescence. Studies suggest that certain core domains of executive functioning (EF), i.e. inhibition, shifting and working memory (WM) may show selectively lower performance in certain INTs. This systematic review aimed to evaluate the evidence of associations between INTs and EF in adol
Aims/hypothesis: The aim of this work was to investigate whether baseline uric acid (UA) is associated with future complications among young individuals with newly diagnosed type 1 diabetes. Methods: UA levels were analysed in individuals, aged 15–34 years with newly diagnosed type 1 diabetes, from the nationwide Diabetes Incidence Study in Sweden (DISS) cohort to assess the relationship with macr
Literature reviewsfrom various countries indicate a difference between calculated and measuredbuilding energy use, often known as the ‘energy performance gap’. This articleexplores the existence and magnitude of the energy performance gap in Swedenand identifies possible reasons behind it. A general evaluation of Swedishbuildings showed a median discrepancy between 10–20%. To explore causes,semi-s
Background Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age worldwide, caused by dysbiosis of the vaginal microbiome. Despite its prevalence, the underlying molecular mechanisms remain poorly understood, making diagnosis and treatment challenging. Although antibiotics are the standard therapy, recurrence rates are high, up to 50% within 1 year, and repe
Objective: To investigate the validity, reliability, and interpretability of the Danish and Swedish versions of the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire (BRAF-MDQ) and Bristol Rheumatoid Arthritis Fatigue Numerical Rating Scales (BRAF-NRS V2) (BRAFs) in patients with spondyloarthritis (SpA). Method: The BRAFs were tested for validity and reliability in an online sur
Dissolved organic matter (DOM) is a major source of macronutrients to freshwaters, yet it has variable and poorly understood bioavailability. Because intrinsic variation in bioavailability is caused by chemical structures of organic nutrients, DOM composition data should improve predictions of bioavailable resource pool sizes. We hypothesized that bioavailable organic carbon (C) and nitrogen (N) f
Industrial dairy membrane processes require frequent cleaning due to hygienic and regulatory demands and lowered efficiency, caused by fouling. This decreases the membrane life cycle and consumes large volumes of rinsing water and cleaning solution. Therefore, the aim of this project is to increase the understanding of membrane fouling and cleaning and to apply this knowledge to develop more ener
