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AIMS: To study the prospective relationship of blood pressure response during orthostatic challenge with incidence of heart failure (HF). METHODS AND RESULTS: In a Swedish prospective cohort study (the Malmö Preventive Project), we followed up 32 669 individuals (68.2% men; mean age, 46 years) over a period of 24 years. Incidence of first hospitalization due to new-onset HF was related to early (6
Objectives:The overall aim of the dissertation is to examine antibody response to immunization with pneumococcal vaccine in patients with inflammatory rheumatic disease (IRD), in relation to disease-modifying antirheumatic drug (DMARD) treatments, and in postsplenectomy patients.Methods:(I) Splenectomized patients without previous pneumococcal conjugate vaccine (PCV) immunization were invited to r
Macroporous hydrogels (MHs), cryogels, are a new type of biomaterials for tissue engineering that can be produced from any natural or synthetic polymer that forms a gel. Synthetic MHs are rendered bioactive by surface or bulk modifications with extracellular matrix components. In this study, cell response to the architecture of protein ligands, bovine type-I collagen (CG) and human fibrinogen (Fg)
Risk assessment constitutes a valuable tool for organizations responsible for critical societal functions in their effort of reducing the likelihood and mitigating the consequences of potentially harmful events. In a previous project, the researchers have contributed to the development and implementation of a method for risk assessment in the municipality of Malmö, Sweden. Shortly after the full-s
Road verges can support high densities of flowers and could therefore provide new opportunities for the conservation of flower-visiting insects. One way of optimizing road verges for vascular plant diversity is to adjust mowing regimes, but to date it is unclear how this affects flower-visiting insects. Furthermore, for mobile organisms like wild bees and butterflies, there is a risk that the bene
We have studied somatic mutation activity early in a response to 2-phenyl-5-oxazolone coupled to ovalbumin (phOx-OVA). Although the V kappa Ox1 gene rearranged to J kappa 5 is known to predominate in this response, other closely related V kappa genes are involved. We compared the introduction of point mutations into V kappa Ox1 genes and into a set of related V kappa genes rearranged to the same J
Soil microorganisms play an integral role in the regulation of carbon (C) cycling. In high-latitude ecosystems, climate warming is leading to higher plant productivity, shrub expansion and faster nutrient cycling; all of which increase resource availability to soil microorganisms. To understand how a legacy of enhanced resource availability affects the functional traits of microbial communities, a
This study aimed to experimentally examine how riverbed drying and different rates of water level reduction influenced the vertical movement of amphipods of various sizes into different subsurface sediment compositions. Using sediment columns (mesocosms) filled with different sized transparent substrates, we explored how varying speeds of drawdown affected vertical movement and stranding of indivi
Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA a
Designing building form in urban areas is a complicated process that demands considering a high number of influencing parameters. On the other hand, there has been an increasing trend to design highly fenestrated building envelopes for office buildings to induce higher levels of natural lighting into the workspace. This paper presents a novel optimization framework to design high-performance build
In an experimental study of humans reactions to social motor intention (SMI) in a humanoid robot, we showed that SMI cause the emergence of social interaction between human and robot. We investigated whether people would respond differently to a humanoid robot depending on the kinematic profile of its movement. A robot placed a block on a table in front of a human subject in three different ways.
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary
Allergic diseases affect many individuals world-wide and are dependent on the interaction between allergens and antibodies of the IgE isotype. Allergen-specific immunotherapy (AIT) can alter the development of the disease, e.g., through induction of allergen-specific IgG that block allergen-IgE interactions. The knowledge of epitopes recognized by allergy-causing and protective antibodies are limi
Strategisk kommunikation har länge förföljts av ryktet att vara omoraliskt, ofta använt synonymt med nedsättande ord som sofistik och propaganda. Forskare inom samhällsvetenskapen har tränats att acceptera denna beskrivning av strategisk kommunikation som en normativ utgångspunkt, genom inflytelserika teorier som Habermas diskursetik och metodologier som kritisk diskursanalys. Denna avhandling utmStrategic communication has long suffered from a reputation of immorality, often being conflated with derogatory terms such as sophistry and propaganda. Scholars in the social sciences have been trained to accept this moralizing idea of strategic communication as a normative point of departure, through influential theories such as Habermas’ discourse ethics and methodological approaches such as cr
Factors behind intraspecific variation in sensitivity to pathogens remain poorly understood. We investigated how geographical origin in two North European amphibians affects tolerance to infection by the chytrid fungus Batrachochytrium dendrobatidis (Bd), a generalist pathogen which has caused amphibian population declines worldwide. We exposed newly metamorphosed individuals of moor frog Rana arv
Introduction: One of the vital skills which has an impact on emotional health and well-being is the regulation of emotions. In recent years, the neural basis of this process has been considered widely. One of the powerful tools for eliciting and regulating emotion is music. The Anterior Cingulate Cortex (ACC) is part of the emotional neural circuitry involved in Major Depressive Disorder (MDD). Th
