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Function of Cerebellar Microcircuitry within a Closed-loop System during Control and Adaptation

The human motor control is both robust and stable, despite large delays and highly complex motor systems with an abundance of actuators, sensors and degrees of freedom. The cerebellum is thought help accomplish this by compensating for external loads and internal limitations and disturbances through adaptation, creating inverse models of the motor system dynamics. The cerebellum does also exhibit

The effect of endothelin receptor blockade on the development of the Sephadex-induced inflammation in the rat lung

The non-peptide ET-receptor antagonist Bosentan was used to investigate the role of endogenous endothelin-1 (ET-1) in the development of the Sephadex-induced lung inflammation in the rat. Intratracheal instillation of Sephadex caused a 60-fold rise in endothelin-1-like-immunoreactivity (ET-1-LI) in bronchoalveolar lavage fluid (BALF) concomitant with development of lung oedema, an influx of inflam

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease

Alzheimer's disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. The S18Y polymorphism of the UCHL1 gene confers

Finding Risk Groups by Optimizing Artificial Neural Networks on the Area under the Survival Curve Using Genetic Algorithms

We investigate a new method to place patients into risk groups in censored survival data. Properties such as median survival time, and end survival rate, are implicitly improved by optimizing the area under the survival curve. Artificial neural networks (ANN) are trained to either maximize or minimize this area using a genetic algorithm, and combined into an ensemble to predict one of low, interme

Consequences of Inadvertent Radioiodine Treatment of Graves' Disease and Thyroid Cancer in Undiagnosed Pregnancy. Can We Rely on Routine Pregnancy Testing?

Introduction. Radioiodine and most cytostatic treatments are contraindicated in pregnancy. Still, inadvertent therapy does occur. Radioiodine was given to two pregnant women with Graves' disease and thyroid cancer respectively, both in their 20th gestational week. Routine pregnancy tests based on urinary β-hCG had failed to indicate pregnancy in both cases. Methods. Estimation of doses to the foet

Who Leads Matters? A study of presidential leadership and its impact on environmental policy

As climate change is a global threat it is of essence to understand how we can work against it. Research within the sphere of Peace and Conflict Studies lacks the perspective of the psychology behind world leaders as an explanation for how environmental policy is conducted. This thesis investigates what type of leader Obama and Trump are, what implications that has on environmental policy and how

Studenternas representanter : En kvantitativ studie av samband mellan socioekonomisk bakgrund och engagemang i studentkåren

In Swedish higher education, the students have a right by law to partake in the decisions that concern them and the education. The participation in such decisions is organized through student representatives elected by the student unions. Previous studies on representation in student unions and politics suggested that a certain socioeconomic background might be overrepresented among the student un

Försvarsmaktens militära profession

In 2016 the Swedish armed forces published a control document, Vår militära profession, which specified the new vision of the Swedish military profession. This study’s purpose is to investigate if Swedish officers view on their profession corresponds with the vision from the control document. Nine qualitative interviews have been conducted with officers of the Southern Skåne Regiment. The study h

Employer attitudes towards people with a psychological disability

Only ten percent of people with disabilities in Sweden hold a salaried employment and one of the main barriers in hiring these individuals is employer attitudes. Using a correlational approach, the aim of this study was to investigate employer attitudes towards hiring people with a psychological disability. Two hundred questionnaires were distributed to headhunters and employers with hiring respon

Effektiva energilösningar för småhus

People's energy needs are constantly increasing, and with rising electricity prices, environmental degradation and reduced fossil fuel reserves of oil in particular, the need for new thinking is necessary. In Sweden, the construction sector stands for 40% of energy consumption and 60% of it is for heating and hot water. With those figures one realize the importance of finding alternative ways

Energieffektiva lösningar för småhus

People's energy needs are constantly increasing, and with rising electricity prices, environmental degradation and reduced fossil fuel reserves of oil in particular, the need for new thinking is necessary. In Sweden, the construction sector stands for 40% of energy consumption and 60% of it is for heating and hot water. With those figures one realize the importance of finding alternative ways

Bloggares beskrivningar av nätmobbning

The purpose of this study was to elucidate the traditional views on cyberbullying and more specifically how others perceive and describe cyber-bullying and its causes, consequences and solutions. To carry out my investigation, I have used qualitative research methods in the form of text analysis. My empirical material consists of 44 Swedish blogs which 28 were written by young people, and the rema

Mot mitten för att vinna val? En studie om moderaternas framgång i svensk politik utifrån en teori om röstmaximerande

In the 2002 election, the Swedish conservative party, Moderaterna, did their worst election in over twenty years. After the 2002 election the party managed to become successful and in eight years the party has doubled their voter support, and has together with the parties from Alliansen managed to win two elections in a row. This study focuses on Moderaterna’s success in Swedish politics in the la

Riktade emissioner - En nödvändighet för börsbolagens nutida kapitalanskaffning?

Då konkurrensen mellan börsbolagen ökat och det generella finansklimatet hårdnat är det i dagsläget nästintill en daglig företeelse att svenska börsbolag genomför olika typer av emissioner. Börsbolagens ökade kapitalbeho¬v har även lett till en klar ökning vad gäller bolagens användning av riktade emissioner och samtidigt åskådliggjort vissa bolags- och aktiemarknads-rättsliga problem som uppstår The increased competition between listed companies on the Swedish stock market (“Stock market” below) in connection with a hardening of the financial climate has made various types of stock issues almost a daily occurrence on the Stock market. The companies’ steadily increasing capital requirements has also led to a significant upturn in the use of targeted stock issues. This development exemplifi

Political Institutions, Integration, and Within-Country Inequality - An Empirical Study

Within-country inequality varies greatly between countries. Despite much research about the determinants of this inequality there is little consensus on what the underlying factors are. This thesis looks into the connection between political institutions, integration and inequality. Both institutions and integration has previously been put forward as important determinants of within-country inequa

The Victim’s Perspective : Essays on Moral Responsibility

This thesis approaches the moral responsibility debate from the “victim’s perspective,” a perspective that is often neglected in the literature. My aim is to show that by taking the victim’s perspective, philosophical discussions can gain a more spherical if not, complete picture of responsibility practices. The thesis explores the implications of adopting or excluding certain perspectives in phil

Dialogue in the making : Emotional engagement with materials

Taking a psychological and philosophical outlook, we approach making as an embodied and embedded skill via the skilled artisan’s experience of having a corporeal, nonlinguistic dialogue with the material while working with it. We investigate the dynamic relation between maker and material through the lens of pottery as illustrated by wheel throwing, claiming that the experience of dialogue signals

EU:s inflytande vid gränskonflikter: Fallet Cypern- En fallstudie av EU:s maktutövning i Cypernkonflikten

This study discusses the European Union´s influence regarding the Cyprus Conflict since 1998, when the EU began the official membership negotioations with Cyprus. The first aim of the study is to investigate in what way the EU has tried to practice influence concerning the Greek- and Turk Cypriots, but also Turkey, since Turkey is seen as a relevant party in the conflict. The second aim of the stu