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BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no

In Sweden there are many laws that apply to government archives. Amongst them are the Public Access and Secrecy Act (offentlighets- och sekretesslagen) which regulates which records are bound by secrecy and which are rendered public. The Public Access and Secrecy Act frequently makes implicit references to a protection of integrity, particularly in its treaties on extradition. To investigate what

The presence of phytate in plants-based food is considered a threat to proper nutrition in developing countries and in particular in rural areas. There is evidence of micronutrient deficiencies due to the presence of phytate in plant-based diets. People from low income households are most affected by diets rich in phytate. The aim of this study was to investigate different processes through which

Antalet olovliga nyttjanden av ensamrätter har ökat under de senaste åren. En immateriell rättighet som inte kan skyddas mot intrång saknar i många avseenden värde. Tillgången av verkningsfulla och effektiva sanktioner är därför en nödvändighet. År 1994 infördes en ny sanktionsform i varumärkes-, mönster- och upphovsrättslagen, nämligen vitesförbud. Sanktionsformen skulle förse rättighetsinnehavarThe number of cases of infringements of intellectual property rights has increased in recent years. An exclusive right, which cannot be protected, lacks value in many aspects. Access to efficient and effective sanctions is therefore essential for rightsholders. In 1994, a new sanction in the Swedish copyright-, design- and trademark act was adopted. The Swedish legislator intended to provide right

Kartlägga buskar på Öland för att rädda den biologiska mångfalden. På södra delen av Öland finns ett område som kallas Stora Alvaret som har mycket höga naturvärden. En minskning av betande djur under 1900-talet har dock gjort att den biologiska mångfalden hotas av buskar som sprider sig och utkonkurrerar andra växter. I examensarbetet Looking for shrubs in an alvar undersöker Jorun Westman metodeLoss of biodiversity is an immediate threat to the planet and if no actions are taken it is expected to accelerate. The highest species richness on smaller scale is found in semi-natural temperate grasslands, with one of the documented records from Stora Alvaret on Öland, Sweden. The area is protected under the Natura 2000-network and Länstyrelsen Kalmar are responsible for monitoring while local

Uppsatsen syftar till att utreda hur rättstillämpningen på S:t Barthélemy fungerade i förhållande till rättstillämpningen i Sverige. Genom en rättshistorisk metod och ett komparativt perspektiv undersöks skillnaderna och likheterna mellan de två rättssystemen. Frågan besvaras genom att närmare undersöka följande tre områden: domstolens sammansättning, lagstiftningen och rättskipningen. DomstolensThe thesis aims to investigate how the adjudication in St. Barthélemy functioned in relation to the adjudication in Sweden. The differences and similarities between the two legal systems are examined through a legal historical method and a comparative perspective. The question is answered by examining the following three areas: the composition of the court, the legislation, and the administration

Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the

Animal venoms and toxins are a valuable source of bioactive peptides with pharmacologic relevance as potential drug leads. A large subset of biologically active peptides discovered up till now contain disulfide bridges that enhance stability and activity. To discover new members of this class of peptides, we developed a workflow screening specifically for those peptides that contain inter- and int

Previous studies of prostate cancer (PCa) risk and anthropometrics (ie, body measurements) were based on single measurements or obtained over limited time spans.

Prostate specific antigen (PSA) is a well-established tumor marker, which is frequently employed as model biomarker to develop and evaluate emerging quantitative proteomics techniques, partially due to wide access to commercialized immunoassays serving as "gold standard". We designed a multiple reaction monitoring (MRM) assay to detect PSA proteoforms in clinical samples (n=72), utilizing specific

This work reports a method to select the optimal working frequency in transversal bulk resonator acoustophoretic devices by electrical impedance measurements. The impedance spectra of acoustophoretic devices are rich in spurious resonance peaks originating from different resonance modes in the system not directly related to the channel resonance, why direct measurement of the piezoelectric transdu

Cell reprogramming concepts have been classically developed in the fields of developmental and stem cell biology and are currently being explored for regenerative medicine, given its potential to generate desired cell types for replacement therapy. Cell fate can be experimentally reversed or modified by enforced expression of lineage specific transcription factors leading to pluripotency or attain

Studies on cultural evolution from archaeology, neuroscience and cognitive semiotics have shown the role of tool making for development of novel cognitive capabilities in early humans. Therefore, it is reasonable to assume that tool making was a cognitive threshold from nonhuman primates to hominins. Tool making begun with rudimentary skills for tool production based on motor patterns, learned soc

Malafouris (2013) proposes that agency is an emergent product of the relational ontology of our material engagement. However, I suggest a distinction between meaning and agency for a better understanding of our relational ontology with things. Meaning is the payoff of the relational ontology, meaning emerges when an agent act within the world. Agency is the capability to act, signify, produce and

The physician’s communication skill influences the patient’s mental and physical wellbeing, as well as the physician’s own experience of stress. Most patients wish to be informed about their disease, by physicians who are honest, gives time, sustains hope, listens and shows compassion and empathy. Even though there are established guidelines on how to break bad news, the physician must find out an

Purpose Previous research shows that the death of a parent places children at risk for a number of negative outcomes. The role of trust in health care at the end of life has been acknowledged as crucial for patients and adult family members. However, the consequences of children’s distrust in the care provided to their parents remain unknown. Therefore, we investigated the negative long-term outco

In Mozambique, despite considerable investments in the promotion of drinking water supplies, the access to quality water of sufficient quantity for the majority of people is still far from optimal. Current official figures report that nearly half of the country´s population and about 45 per cent of urban residents do not have access to safe water. As a result of poor performance or absence of publ