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Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on primary AML CD34+CD38-cells relative to corresponding normal bone marrow cells. Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 inMLL-AF9-driv

Lung cancer accounts for 1.6 million deaths per year worldwide. The majority of patients are diagnosed at advanced stages of the disease and often present with metastasis. Thus, the 5-year survival rate of lung cancer remains around 15%. Early diagnosis of lung cancer allows for better control of the disease with 5-year survival rates up to around 70%. Chest radiography is the most common techniqu

Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph(-)) cell population. A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid l

Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. By screening combinations of 1

Objective: To investigate the effectiveness of a culturally adapted lifestyle intervention for changing dietary intake, particularly energy, fat and fibre intakes, in the intervention group (IG) compared with the control group (CG). Design: Randomised controlled trial. Setting: IG (n 50) and CG (n 46). The IG was offered seven group sessions, including one cooking class, over a period of 4 months.

Purpose -The purpose of this paper is to investigate the added value of using temperature-dependent electric and magnetic properties in high-Temperature electromagnetic simulations. Design/methodology/approach - In this work, the electromagnetic properties of Domex 420, SSAB, have been characterized as a function of the temperature, from room temperature to 900°C. The measurement of the electric a

The Swedish HE Ordinance requires all supervisors of doctoral students to undergo introductory training. The content, goals, learning outcomes and duration is not specified by the Ordinance and thus practices vary between institutions. In 2009/2010, a new study program for doctoral supervisors was launched at Lund University. The program was designed to:- provide research-based support for doctora

Popular Abstract in Swedish Svensk Kärnbränslehantering AB, SKB, har i uppdrag att ta hand om allt radioaktivt avfall från de svenska kärnkraftverken. En av förutsättningarna för att SKB ska få tillstånd att uppföra inkapslings- och slutförvars¬anläggningarna är att metod och teknik för att försluta kapslarna finns. De förslutna kapslarna ska uppfylla de krav på långsiktig säkerhet som SKB, myndigThis thesis presents the development to reliably seal 50 mm thick copper canisters containing the Swedish nuclear waste using friction stir welding. To avoid defects and welding tool fractures, it is important to control the tool temperature within a process window of approximately 790 to 910°C. The welding procedure requires variable power input throughout the 45 minute long weld cycle to keep th

Whereas the characterization of B lymphoid progenitors has been facilitated by the identification of lineage-and stage-specific surface markers, the continued identification of differentially expressed proteins increases our capacity to explore normal and malignant B cell development. To identify novel surface markers with stage-specific expression patterns, we explored the reactivity of CD19+ B c

What is woman’s role in the modernist avant-garde? Feminist art historians have long criticised the dominant masculinity of modernism. The problem, as I see it, is the unreflecting way in which history is written, and the way in which women are squeezed into theoretic models that really only affirm, and cater primarily for, men. The German-Swiss artist Meret Oppenheim (1913-1985) has been describe