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Background: Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear. Objective: Evaluate previously identified SNPs for association with prostate cancer and accuracy in predicting prostate cancer in a large prospective population-based cohort of unscreened men. Design, setting, an

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

The antibody microarrays have become widespread, but their use for quantitative analyses in clinical samples has not yet been established. We investigated an immunoassay based on nanoporous silicon antibody microarrays for quantification of total prostate-specific-antigen (PSA) in 80 clinical plasma samples, and provide quantitative data from a duplex microarray assay that simultaneously quantifie

Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissi

In the research on two of the most prominent persons among those who rescued Jews from the Holocaust, Oskar Schindler and Raoul Wallenberg, a reappearing purpose has been to separate mythical, and therefore more or less false, elements in the story from the true, and implicit, academic historical writing. However, during the last decades, it has been obvious that history is not only, and sometimes

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. There have been several reports of miRNA deregulation in prostate cancer and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing. In this study, we show that miR-34c is downregulated in prostate cancer (p = 0.0005) by performing qRT-PCR on 49 TURPs from prosta

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroid defect remain elusive. Previous studies have indicated that activation of p53

The transcription factor STAT3 is constitutively active in several malignancies including castration-resistant prostate cancer and has been identified as a promising therapeutic target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces apoptosis of prostate cancer stem cel

Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on redu

This bachelor thesis addresses women's trust in the Swedish judicial system in regard to sexual offences with the ultimate aim of detecting any differences in trust between the age groups of 18-21, 22-25 and 26-29 years old as well as district and city location and size. The outset for this was an internet-based survey, which was shared in two of the biggest Swedish Facebook groups for women.

In the European Union there are special schemes in Value Added Tax that Member States may adopt. Those rules are set out in the VAT Directive. Two of those special schemes are the special scheme for small enterprises and the common flat-rate scheme for farmers. Along to the provisions of the VAT Directive there is also some case law from the CJEU that clarifies the application of the schemes. Ger

Under "The Big Bang" så bildades den materia som idag utgör vårt universum. Enligt den teoretiska så kallade "Standardmodellen" i partikel fysik så skulle det i detta skede bildats lika mycket materia som antimateria. Men observationer idag visar sig att i princip all antimateria är på något vis bortkommet. Denna motsägelse av en annars väl bevisad teoretisk modell är något somThis work relates to the proposed n-nbar experiment at ESS and covers a procedure with which future neutron research can be made using a small TPC prototype. Settings for the GEM amplification voltage supply and main drift field across the chamber have been established using minimum ionizing cosmic muons as a reference. To be able to reconstruct tracks in three dimensions and measure the deposited