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PURPOSE: Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551). The use of (99m)Tc instead of (111)In should improve sensitivity and resolution of

Through a systematic review and a series of meta-analyses, we evaluated the general responsiveness of putative transcriptional biomarkers of general toxicity and chemical stress. We targeted metal exposures performed on bivalves under controlled laboratory conditions, and selected six transcripts associated with general toxicity for evaluation: catalase (cat), glutathione-S-transferase (gst), heat

This work is a continuation of the research recently presented in [1] and [2] on the determination of residual thermal stresses in graphite/polyimide composites with and without externally applied bending loads. In the previous work [1, 2] a combined experimental and numerical methodology for the determination of the residual stresses in unidirectional graphite/PMR-15 composites based on X-ray dif

The purpose of this research is to determine residual thermal stresses in a unidirectional graphite-fiberT/PMR-15 polyimide composite by using crystalline inclusions. X-ray diffraction (XRD) measurements have been made to determine residual stresses in embedded aluminum and silver inclusions placed between the first and second plies of six-ply unidirectional graphite/PMR-15 composite specimens. In

Analytical solutions for a one-line model for shoreline changes are employed to investigate the formation of two wave-dominated river delta coastlines, along with a small-scale laboratory experiment. Since the present analytical solution can be applied only to a river delta with infinite shorelines, a new analytical solution was developed to consider the effects of lateral boundaries to the evolut

There is no inherent meaning in endurance experiences. The experience is accorded meaning in dialogue with the world around us. In this critical exploration of endurance running, endurance runners’ accounts of their consumption of endurance are analysed to reveal what they indicate about contemporary society. The findings question the idea - prevalent in consumer research - that endurance experien

Protein complex formation is encoded by specific interactions at the atomic scale, but the computational cost of modeling proteins at this level often requires use of simplified energy models and limited conformational flexibility. In particular, use of all-atom energy functions and backbone and side-chain flexibility results in rugged energy landscapes that are difficult to explore. In this study

Phobias have historically and evolutionary been vital for humans to escape quickly or fight in dangerous situations. The anxieties that phobias evoke have made people live longer. Evolutionarily, anxiety has been good, but fear and anxiety come in unjustified situations for the civilized population in the 21st century. Some people have an extra sensitive reaction system activated too often in irre

Background: Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based evidence is still lacking. Methods: By accessing a couple of nationwide Swedish registers, we performed a cohort study to explore whether using proguan

Refugee integration is a highly politicised topic and is rarely analysed from a legal perspective. This contribution aims to address this gap by tracing the potential of the right to be integrated in legal terms, analysing its legal sources in European human rights law, and in European Union (EU, the Union) law, using a doctrinal method. It answers the question: is there a state obligation to prov

Previous observations have indicated that topical application to the rabbit eye of tachykinin antagonists, including spantide, effectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. The present study shows that spantide is taken up into the rabbit eye following topical application. This was established by determination of spantide in the aqueou

Purpose: Finasteride has been shown to reduce the incidence of prostate cancer. Yet the use of finasteride remains low, likely because of the risk of adverse effects. We sought to determine whether prostate-specific antigen (PSA) levels could identify a high-risk subgroup for which the benefits of finasteride treatment outweigh the potential harms. Patients and Methods: Raw data from the Prostate

The objectives of this study were to analyse the changes in airway cross-sectional areas and volumes due to surgical movements of the jaws and to identify any possible correlation with the direction of the movements. Fifty-seven participants, aged 18–28 years (mean 20.8 years) at surgery, were followed up for 12 months postoperatively. Pre- and postoperative measurements of the facial region obtai

Background. The urokinase plasminogen activator (uPA) system is involved in tissue remodelling processes and is up-regulated in many types of malignancies. We investigated whether serum levels of different forms of soluble uPA receptor (suPAR) are associated with survival and in particular with prostate cancer and cardiovascular disease mortality. Methods. Using time-resolved fluorescence immunoas

Pop is increasingly assimilating the compositional practices of hip- hop and EDM (electronic dance music). This shift is driven by a new generation of Digital Audio Workstations (DAWs). These are less based on a recording studio logic and more a combination of controlling loops and the networked logic of ubiquitous computing (ubicomp) culture. Via new media theory, this article discusses how the p

Background: Long-distance migratory birds undergo complex annual cycles during which they must adjust their behaviour according to the needs and conditions encountered throughout the year. Yet, variation in activity throughout the entire annual cycle has rarely been studied in wild migratory birds. Methods: We used multisensor data loggers to evaluate the patterns of activity throughout the comple