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Background: In 2015, a proton therapy (PT) facility was established in Sweden with one aim being to ensure access for all children expected to benefit from PT. Despite potential dosimetric advantages and full subsidisation, PT is not always selected. This study explores reasons for choosing alternative radiotherapy (RT) modalities in a paediatric population. Material and methods: RT courses delive
Biases in animal behaviour research are inevitable consequences of our societal and cultural standpoint. To remove our biases, the first stage is to identify them. We call on individual researchers to adopt a more active approach to addressing bias within their research. We propose that biases exist within a matrix defined by the general acceptance of a bias's existence and the understanding of th
We study the effects of principal instructional leadership on pupil educational achievement using longitudinal data of 120,394 teacher responses across 1919 schools in Sweden over 9 years. Through multilevel structural equation modelling, we test how teacher ratings of principal leadership influence indicators of educational achievement and the extent to which this effect is channelled through a c
The Sörvik granite forms rounded intrusions in the dominating Revsund granite, north-eastern Jämtland, central Sweden. Laser-ablation single-collector magnetic sector field-inductively coupled plasma-mass spectrometry on zircons was used to date the granite. The zircons are inhomogeneous, some with evident cores. The fractionation curves, 207Pb/235U versus time (depth), are irregular and often inc
Complexity and innovation are emerging as fundamental issues for the future of human life and society. To deal with them, different versions of systems thinking have been proposed. However, System-of-Systems (SoS) thinking, based on the biperspectival principle and human reflexivity, has not yet been clearly recognized. The unclear distinction between ‘systems’ and ‘SoS’ thinking often results in
Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. Transforming growth factor-β (TGFβ) induces the expression of this plasma membrane protein specifically in aggressive and treatment resistant tumor cells derived from mesenchymal stem cells, with minimal expression observed in non-neoplastic tissues. We have developed a humanized monocl
Plasma-assisted technologies are rapidly advancing and are set to play a crucial role in the green transition. One challenge in this development, specifically tied to laser-based plasma diagnostics, is the presence of interfering plasma-induced emissions, such as the de-excitation of naturally excited species, which can complicate the detection of laser-induced signals. Successfully differentiatin
INTRODUCTION: In drug facilitated sexual assault (DFSA) the victim is unable to consent to the sexual act due to influence of alcohol, narcotics, or medicine. Increasing the awareness of characteristics associated with DFSA can assist the judicial system in early recognition of cases and guide public health interventions for reducing DFSA. This study aims to assess characteristics of DFSA victims
Background Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown. Methods A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden
OBJECTIVE: To estimate the prevalence and predictors of sustained remission (SR) in patients with psoriatic arthritis (PsA) receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in Sweden. METHODS: All patients with PsA initiating b/tsDMARDs and who were registered in the national Swedish Rheumatology Quality Register (SRQ) from April 1999 to December 2019 wer
Aims Cardiac allograft vasculopathy (CAV) is a significant complication that contributes to both morbidity and mortality after heart transplantation. The aim of this study was to (i) assess if quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion could detect different stages of CAV and (ii) establish a myocardial perfusion reserve (MPR) cut-off for significant CAV. Methods and
In the post-World War II era, international lawyers have occupied the front seat in the study of international organisations (IOs). During the past decade, this disciplinary hierarchy has grown to feel increasingly unsatisfying. This chapter offers an anthropological take on the study of IOs building both on the past decade of anthropological work and my ethnography at the UN Human Rights Committe
The Economic Dispatch Problem (EDP) plays a critical role in power system operations by trying to allocate power generation across multiple units at minimal cost while satisfying complex operational constraints. Traditional optimization techniques struggle with the non-convexities introduced by factors such as valve-point effects, prohibited operating zones, and spinning reserve requirements. Whil
Digital innovation offers promising avenues for accessible, engaging, and user-friendly training solutions, crucial for promoting safety among manufacturing workers. However, optimizing these solutions demands a profound understanding of workers’ needs and preferences in interacting with these digital systems. The ongoing “DigiSafeMan” project aims to develop a prototype of a digital training tool
There has been great interest in the rationales for transformative innovation policies (TIP), including those following a mission-oriented logic. However, few studies have investigated how public administration can effectively implement TIP. To study this, we first identify from existing literature four TIP governance tasks (creating legitimacy and leadership, coordination across levels/instrument
Pathogenic variants of human CDC14A (cell division cycle 14A) are associated either with nonsyndromic deafness DFNB32 or HIIMS, hearing impairment infertile male syndrome. The 623-residue CDC14A protein has two globular domains (residues 17-152 and 217-325) and a 278-residue C-terminal intrinsically disordered region (IDR). To date, 16 recessive variants of human CDC14A are associated with hearing
Quantitative investigation of insect activity in their natural habitat is a challenging task for entomologist. It is difficult to address questions such as flight direction, predation strength and overall activities using the current techniques such as traps and sweep nets. A multi-spectral kHz remote detection system using sunlight as an illumination source is presented. We explore possibilities
