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BACKGROUND: The aims of this study were to determine which consent procedure patients prefer for use of stored tissue for research purposes and what the effects of consent procedures on actual consenting behaviour are.METHODS: We offered 264 cancer patients three different consent procedures: 'one-time general consent' (asked written informed consent), 'opt-out plus' (had the opportunity to opt ou

Background: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) helpBackground: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) help

Popular Abstract in Swedish Det är en viktig uppgift för samhället att förebygga HIV och STI (sexuellt överförbara infektioner) bland ungdomar. Under de första åren av 1990-talet, när denna studie genomfördes, ökade dessa infektioner på ett oroväckande sätt. Detta gällde särskilt klamydiainfektionerna och nästan 25% av studenterna vid Lunds universitet rapporterade att de hade haft en konstaterad Slowing the incidence of HIV and STI among young people requires that they change their sexual behaviours. There is evidence that community-based interventions that target multiple levels of influence can be effective. In community mobilization different segments and sectors of a population are directly involved in problem identification and in the design and implementation of programs. The proces

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA I blodet finns en mängd olika celltyper som alla har sin specifika funktion. De röda blodkropparna (erytrocyterna), transporterar livsnödvändigt syre till kroppens alla vävnader. De vita blodkropparna (leukocyterna), vilka inkluderar lymfocyter, monocyter och granulocyter, deltar i kroppens immunförsvar och skyddar kroppen Hematopoiesis is a highly complex process by which a range of specialized blood cells are generated from a small pool of multipotent stem cells in the bone marrow. The survival, proliferation, and differentiation of hematopoietic stem cells are tightly regulated by both soluble and membrane-bound cytokines produced within the bone marrow microenvironment. Kit Ligand (KL) and Flt3 Ligand (FL) are t

International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV-related liver disease and important biological and antigenic differences that exist between variants. A group of scientists expert in the field of HCV genetic variability, and those involved in development of HCV sequence data

Replication of tobacco mosaic virus (TMV) is connected with endoplasmic reticulum (ER)-associated membranes at early stages of infection. This study reports that TMV movement protein (MP)-specific protein kinases (PKs) associated with the ER of tobacco were capable of phosphorylating Thr104 in TMV MP. The MP-specific PKs with apparent molecular masses of about 45–50 kDa and 38 kDa were revealed by

Popular Abstract in Swedish Depression är en av de stora folksjukdomarna och drabbar varannan kvinna och var fjärde man någon gång under deras livstid. Vid djupa depressioner, då självmordsrisken är hög eller då patienten hamnat i ett livshotande tillstånd på grund av oförmåga att äta och dricka används elektrokonvulsiv terapi (ECT), eller som det ofta kallas, ”elbehandling”. Ungefär 45 000 patienElectroconvulsive therapy (ECT) is a well-established treatment for severe depressive disorder, but its clinical use has been limited by concerns about side effects such as memory disturbances. Despite over 70 years in clinical use, the exact mechanisms of action behind the therapeutic or adverse effects are not fully understood. Enhanced brain plasticity, including neurogenesis, angiogenesis and

Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: 4,666 controls were pooled

Bose-Einstein correlations (BEC) between final state particles in the reaction e(+)e(-) -> W+ W- -> q(1)(q(2)) over barq(3)(q(4)over bar>) over bar) have been studied. Data corresponding to a total integrated luminosity of 550 pb(-1), recorded by the DELPHI detector at centre-of-mass energies ranging from 189 to 209 GeV, were analysed. An indication for inter-W BEC between like-sign particles has

Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to

Popular Abstract in Swedish Intresset för biobränsle som en alternativ energiresurs har ökat eftersom utsläppen av CO2, NOx och SO2 bör sänkas. Användningen av biobränsle i en trycksatt fluidiserad bädd förbrännare/förgasare är därför en teknik som är lovande. En fluidiserad bädd har en rad fördelar såsom effektiv värmeöverföring, bränsleflexibilitet och låg förbränningstemperatur. Trots sina fördIncreasing awareness of the need of reducing CO2, NOx and SOx emissions from combustion systems has led to a strong interest in biomass as a fuel source. Using it in combination with fluidised bed combustion technology can lead to a lowering of NOx emissions to the atmosphere. However, this is not a problem-free technique, since the flue gas can contain ammonia, NOx and tar. The fluidised bed can

Popular Abstract in Swedish Utövandet av läkekonsten består till en del av rent medicinsk-tekniska insatser som grundas på vetenskap och beprövad erfarenhet. Dessa insatser äger rum inom ett omvårdnadssammanhang, och här anses den personliga relationen vara ytterst betydelsefull för patientens tillfrisknande. Patienter och vårdpersonal har specifika roller som ej är jämlika. Rollinnehåll och rollThe personalities and qualities of nursing personnel are considered to be of great importance for their interactions with patients and may also influence work satisfaction. The aim of the thesis was to explore the extent to which different personal qualities and personality factors, with a possible effect on motivation, professional conduct, and coping with anxiety, are represented in a group of a

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

Syftet med examensarbetet har varit att åstadkomma en kapacitetsökning i Thom Lightings lager i Landskrona. Målet var att bestämma hur en lämplig lagerlayout med ett smalgångsalternativ skulle se ut och hur mycket kapacitetsökning denna lösning skulle åstadkomma. Ytterligare en målsättning var att se över vilka rutiner som krävs för att skapa ett effektivt lager och slutligen göra en simulering so

INTRODUCTION: Whether low socioeconomic status (SES) is associated with worse rheumatoid arthritis (RA) outcomes in countries with general tax-financed healthcare systems (such as Sweden) remains to be elucidated. Our aim was to investigate the influence of educational background (achieving university/college degree (high) or not (low)) on the outcomes of early RA, in terms of disease activity (DA

Essentials: High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial of late/tertiary prophylaxis vs on-demand therapy. Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy.

The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear. To address this, we globally resolve their individual properties and inter-relationships. We purify 18 of the human NUDIX proteins and screen 52 substrates, providing a subs