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Histamine stimulates progesterone synthesis and cyclic adenosine 3',5'-monophosphate accumulation in isolated preovulatory rat follicles

The effect of histamine on progesterone synthesis and cyclic adenosine 3',5'-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H2-antagonist, cimetidine, inhibited completely the histamine-i

Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8

HLA DQA1(*)0301-DQB1(*)0302 (DQ8) and DQA1(*)0501-DQB1(*)0201 (DQ2) are positively and DQA1(*)0102-DQB1(*)0602 (DQ6) negatively associated with IDDM. In DQA1(*)0301-DQB1(*)0302 (DQ8)-positive patients, susceptibility is also mediated by DRB1(*)0401. The aim of the study was to determine the association between HLA-DR4 and DQ and the presence of GAD65, ICA512, and insulin autoantibodies as well as

Visual fields at different stages of diabetic retinopathy

Available studies on visual field disturbances in diabetic retinopathy have shown conflicting results, obtained with different and often non-comparable techniques. We have studied visual fields at different stages of diabetic retinopathy with modern sensitive computerized technique taking precautions to limit disturbing effects of random field variation and lack of perimetric experience. Sixty-thr

Facing challenges during occupation : Middle eastern immigrants' paths to occupational well-being in sweden

Occupational well-being is a central issue underpinning factors that constitute a good life. This study aimed to explore occupational well-being among Middle Eastern immigrants to Sweden, as reflected in the occupations performed in the context of psychosocial health care. Ten participants experiencing mental health issues, who received occupation-based rehabilitation, were interviewed. Grounded t

In vivo acetylcholine release as measured by microdialysis is unaltered in the hippocampus of cognitively impaired aged rats with degenerative changes in the basal forebrain

Acetylcholine (ACh) release was studied in awake, freely moving animals using in vivo microdialysis in the hippocampus of young (3-month-old) and aged (24-month-old) female Sprague-Dawley rats. Two groups of aged rats were selected on basis of their spatial learning performance in the Morris water maze: non-impaired aged rats which performed as well as the young control animals, and impaired aged

Electromagnetic polarizabilities of nucleons bound in 40Ca, 16O and 4He

Differential cross sections for elastic scattering of photons have been measured for 40Ca at energies of 58 and 74 MeV and for 16O and 4He at 61 MeV, in the angular range from 45° to 150°. Evidence is obtained that there are no significant in-medium modifications of the electromagnetic polarizabilities except for those originating from meson exchange currents.

Prolonged opioid use after distal radius fracture

BACKGROUND: Prolonged opioid use (more than 90 days) after injury puts the patient at risk for adverse effects. We investigated the patterns of opioid prescription after distal radius fracture and the effect of pre- and post-fracture factors on the risk for prolonged use.METHODS: This register-based cohort study uses routinely collected health care data, including purchases of prescription opioids

Area under the curve : Comparing the value of factor VIII replacement therapies in haemophilia A

Introduction: In factor VIII (FVIII) prophylaxis for haemophilia A, cost comparisons have used price per international unit (IU) based on the once reasonable assumption of equivalent outcome per IU. Now, with several extended half-life (EHL) products available, new outcome-oriented ways to compare products are needed. Area under the curve (AUC) quantifies FVIII levels over time after infusion prov

Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo

Regulatory T cells (T(reg)) are currently being tested in clinical trials as a potential therapy in cell and solid organ transplantation. The immunosuppressive drug rapamycin has been shown to preferentially promote T(reg) expansion. Here, we hypothesized that adjunctive rapamycin therapy might potentiate the ability of ex vivo expanded human T(reg) to inhibit vascular allograft rejection in a hum

Tracing Sustainability in the Long Run : Genuine Savings Estimates 1850 - 2018

We introduce a new database of historical Genuine Savings (GS), an indicator of sustainable development promoted by the World Bank and widely used in contemporary economic research. GS derives from the theoretical work on wealth accounting, and addresses shortcomings in conventional metrics of economic development by incorporating broader measures of saving and investment, including human capital

Prevalence of depression and anxiety in older people in low- and middle- income countries in Africa, Asia and South America : A systematic review and meta-analysis

BACKGROUND: There is rapid growth of older people in Low- and Middle- Income Countries (LMICs). The aim of this review was to assess the literature on prevalence of anxiety and depression in this demographic, which to our knowledge, has not yet been conducted.METHODS: Databases including Medline, PsychInfo, Embase, Scielo and African Journals Online were searched for terms including "mental disord

Introduction to Living Standards in the Past

In the introduction, different contributions are brought together in an analysis of pre-industrial living standards in East and West, viewed in the light of the general debate on these issues from the classical economists to present times. The general picture emerging is not one of great divergence, but instead one of considerable similarities. Regional differences within Europe or Asia were often

Osteonecrosis of the jaw among patients with cancer treated with denosumab or zoledronic acid : Results of a regulator-mandated cohort postauthorization safety study in Denmark, Norway, and Sweden

BACKGROUND: Osteonecrosis of the jaw (ONJ) is an adverse effect of antiresorptive treatment. This study estimated incidence proportions and incidence rates of ONJ in cancer patients with bone metastases from solid tumors treated for the prevention of skeletal-related events in routine clinical practice.METHODS: This cohort study in Denmark, Norway, and Sweden in 2011-2018 included 3 treatment coho

Designing smart call forwarding: creating a new type of product

Nya system skapar svårigheter då man inte kan använda redan etablerade metaforer, designer eller sätt att beskriva och prata om systemet. Detta arbetet ämnar att underlätta arbetet med sådana system genom att erbjuda designprinciper och metodiker för att jobba med dem och undersöka vilka svårigheter man behöver vara medveten om. För att forma och testa nya designprinciper och metodiker så genomföOne of the difficulties in designing new products is the absence of already tried metaphors, designs or ways to talk about the system. This thesis focuses on methods and practises one could potentially use when designing something new - and if there are any challenges one need to aware of as a designer of such a system. In order to devise, and test, these practices and methods, an example system

The "EU Climate Bank"? - A study on the environmental commitments of the European Investment Bank and the alignment with the right to a healthy environment

Den här uppsatsen undersöker förhållandet mellan internationella finansiella institutioner, mänskliga rättigheter och miljö. I kampen mot klimatförändringar har hållbar finansiering lyfts fram som en åtgärd för att stödja skiftet till en hållbar ekonomi. Internationella finansiella institutioner är centrala aktörer i omväxlingen mot en hållbar ekonomi och utgör de främsta tillhandahållarna av offeThis thesis examines the relationship between international finance and environmental rights, and how the concept of sustainable finance has emerged as a response to climate change and the rapid transition towards a sustainable economy. Multilateral development banks (MDBs) are a key player in the transition to a green economy, contributing to 68% of global climate finance. Thus, MBDs are the majo

Next Stop: Value Creation - Analysing the Potential to Enhance Public Transport Authorities’ Strategic Corporate Social Responsibility by Providing Mobility as a Service

Concepts such as Creating Shared Value [CSV] and Strategic Corporate Social Responsibility [SCSR] respond to a demand for organisations to take responsibility for their contributions to increasing social issues such as social exclusion or the effects of climate change. The concept of SCSR is describing activities that provide economic values for organisations while at the same time targeting socia

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This bachelor thesis studies the syntactic structures in four textbooks in German as a foreign language used in the Swedish upper secondary school (the gymnasium). The aim of the study is to test whether the German syntax is presented in such a way that it becomes optimally processable for learners. Research on grammatical developmental stages has shown that learners of a language acquire grammati

Love thy neighbor: social sustainability assessment in built environments : the case of the Greenhouse project in Augustenborg ecocity, Malmö, Sweden

Även om en av de tre pelarna i hållbarhetstriaden bredvid den ekonomiska och miljömässiga är social hållbarhet (SS) den minst studerade och undersökta. Eftersom dess definition, mätning och drift är föremål för olika tolkningar, tenderar social hållbarhet att undervisa och ibland förbises. Denna förklarande fallstudie undersöker de sociala hållbarhetsaspekterna i det lilla samhället i Greenhouse pAlthough one of the three pillars of the sustainability triad beside the economic and environmental, Social Sustainability (SS) is the least studied and researched. Since its definition, measurement and operation are subject to different interpretations, SS tends to be undertheorized and sometimes overlooked. This explorative case study investigates the SS aspects of the small community of the Gre

Stjärnfamiljer och kärnfamiljer - En kritisk diskussion kring flersamt föräldraskap i svensk familjerätt

How we choose to organize our families has changed significantly since the mid-20th century. It might be true that the nuclear family remains the most common family form. However, it has to an increasing extent been accompanied by a number of non-traditional families, including same-sex families. Naturally, this development has also affected the way we live and how we practice family life. While

DEN INBILLADE LÄRAREN - Utveckling av undervisning genom aktionsforskning

In this study, the initial aim was to combine the roles as teacher and researcher in a project called “The Inner Teacher”. The teacher-researcher wanted to study if, and in that case how, organ students on an academic level had access to an inner teacher when approaching a written piece of organ music. The study was interrupted by the fact that the teacher-researcher failed to act as planned when