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In many developing tropical countries, rapid urban growth leads to several problems, including increased thermal stress. This has negative consequences for people's health and well-being, and affects social and commercial outdoor activities negatively. Consequently, the creation of thermally comfortable microclimates in urban environments is highly important. The main aim of this thesis is to dee
Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents as macrocytic anemia during infancy. Linkage analysis suggests that at least four genes are associated with DBA of which two have been identified so far. The known DBA genes encode the ribosomal proteins S19 and S24 accounting for 25% and 2% of the patients respectively. This study shows that RPS19 gene transfer
Popular Abstract in Swedish Denna avhandling redogör för cellulär lokalisation, reglering och funktion av två nya peptider, ghrelin och CART, i pankreas (bukspottskörteln). Pankreas och de Langerhanska öarna: Pankreas består av en exokrin del, som producerar matspjälkningsenzymer till mag-tarm kanalen, och en endokrin del som producerar hormoner som insöndras i blodomloppet. Endokrina pankreas bUntil recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. The cells are developmentally regulated in that they are numerous around birth and fewer in the adult. The islet ghrelin cell
Popular Abstract in Swedish En autonom agent kan definieras som ett system som med syfte att utföra uppgifter kan interagera med sin omgivning genom sina egna sensorer och effektorer. En ny arkitektur för autonoma agenter inspirerad av teorin för antecipatoriska system föreslås. Det är en hybrid arkitektur i det avseende att den kombinerar planerande förmåga, som behövs för att lösa långsiktiga prThis thesis has two main themes, autonomous agents and concepts. An autonomous agent is a system capable of interacting with its environment via its own sensors and effectors in order to accomplish some task. Arguments against both purely reactive and purely deliberative agent architectures are presented in favor for hybrid approaches. A novel hybrid approach based on the concept of anticipatory s
The CD4+ T cells have an important role in inflammation. Based on the local cytokine milieu, these cells can differentiate into either a Th1 population promoting cellular immunity or Th2 population involved in humoral immunity. Th2 cells produce the anti-inflammatory cytokines IL-4 and IL-10, which might have a protective role in autoimmune diseases like rheumatoid arthritis (RA) and multiple scle
Popular Abstract in Swedish Emilia Fogelklou (1878-1972) utbildades vid Högre Lärarinneseminariet och Uppsala universitet, där hon som första kvinna i Sverige tog en teologie kandidat (1909). En stark gudsupplevelse i unga år hade kommit att styra hela hennes liv. Hon fick så småningom sitt religiösa hem hos kväkarna. Som sökare och gränsöverskridare spände hennes liv och verk över vida fält, främEmilia Fogelklou (1878-1972) was the first woman in Sweden to take a degree in theology (1909) and later became a Quaker. She was a teacher and writer, mainly in the fields of religious education and psychology, and an active supporter of peace and other women's movements. Her autobiographical series, Arnold (1944), Bareheaded (1950), and Ready to Travel (1954), is written in the third person, Fog
Popular Abstract in Swedish ABSTRAKT Titel: Organ improvisation - activity, action and rhetorical practice [Orgelimprovisation - verksamhet, handling och retorisk praktik]. Författare: Karin Johansson Språk: Engelska Sökord: Orgelimprovisation, kulturhistorisk verksamhetsteori, högre musikutbildning, västerländsk konstmusik, diskursiv praktik, retorisk praktik. ISSN: 1404-6539 ISBN: 978-91-976053-This thesis focuses on contemporary organ improvisation in Western European musical culture. The aim of the study is to explore organists’ descriptions, constructions and definitions of improvisation in words and music, with an interest in the interaction between receptivity, creativity and change. As a research object, the art of organ improvisation is defined as a source for exploring learning a
Pharmacokinetic and pharmacodynamic activities of the antidepressants venlafaxine (VEN) and citalopram (CIT) were investigated in the portacaval shunted (PCS) rat, a model of chronic hepatic encephalopathy (HE), and normal/control rats. The levels of VEN in serum and brain were higher in PCS rats than in controls after a single injection and chronic treatment with VEN (10 mg/kg). After reducing th
Renewable energy sources dominated the world energy supply until the beginning of the 20th century, when fossil energy became the dominant energy source worldwide. Today, fossil fuels contribute to over 80% of world energy supply. But there are two major reasons why fossil energy use has to stop. First, fossil energy is limited and will not last forever. Second, emissions of carbon dioxide change
Germline mutations in the breast and ovarian cancer susceptibility gene BRCA1 are responsible for the majority of cases involving hereditary breast and ovarian cancer. Whereas all truncating mutations are considered as functionally deleterious, most of the missense variants identified to date cannot be readily distinguished as either disease-associated mutations or benign polymorphisms. The C-term
The effect of different additives on protein stability was studied, and the basis for stabilization was investigated at molecular level. The addition of sorbitol enhanced thermal stability of hen egg white lysozyme in aqueous solution. NMR spectroscopy revealed changes in the relaxation properties of Ala and Thr methyl groups in lysozyme, indicating compression of the enzyme as a consequence of pr
A phonetogram is a diagram displaying sound pressure levels (SPL) of softest and loudest possible phonation over the entire fundamental frequency range (F0) of a voice. Female singers mean phonetogram had a significantly higher upper contour than female nonsingers. When reading at various voice levels female singers produced markedly higher mean equivalent sound pressure levels (Leq) and mean rel
BACKGROUND: Multi-atlas segmentation, a popular technique implemented in the Automated Segmentation of Hippocampal Subfields (ASHS) software, utilizes multiple expert-labelled images ("atlases") to delineate medial temporal lobe substructures. This multi-atlas method is increasingly being employed in early Alzheimer's disease (AD) research, it is therefore becoming important to know how the constr
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10×10
Purpose: To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.Methods: This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty Scale
The gamma decay of the 12(+) yrast trap in Fe-52 has been measured for the first time. The two E4 gamma-branches to the 8(+) states are hindered with respect to other B(E4) reduced transition probabilities measured in the f(7/2) shell. The interpretation of the data is given in the full pf shell model framework, comparing the results obtained with different residual interactions. It is shown that
This presentation will engage with the issue of educational reform in the Middle East, discussing preliminary findings of a recently initiated research project on community based educational projects in Beirut. Such initiatives will be discussed in relation to national Lebanese educational policies and practices, as well as in relation to international educational programs such as Education for Al
Sinus tachycardia (ST) is ubiquitous, but its presence outside of normal physiological triggers in otherwise healthy individuals remains a commonly encountered phenomenon in medical practice. In many cases, ST can be readily explained by a current medical condition that precipitates an increase in the sinus rate, but ST at rest without physiological triggers may also represent a spectrum of normal
Popular Abstract in Swedish Cellulosa är ett av de vanligast förekommande biologiska ämnena på jorden och en mycket viktig råvara. Cellulosa är en polymer, uppbyggd av glukosmolekyler som är bundna till varandra i kedjor. Kedjorna kan bli mycket långa och består ofta av flera tusen glukosmolekyler. Eftersom cellulosakedjor är lineära kan de packa sig parallellt med varandra och bilda styva fibrer Soluble derivatives of cellulose have become increasingly important in industrial products e.g. in pharmaceutical applications and in technical dispersions. The polymer characteristics of modified celluloses are to a high degree determined by the substituent distribution along the polymeric backbone. The distribution will be more or less heterogeneous both due to the fact that polymers from renewa
In Swedish higher formal aesthetic education, students from ethnic minorities are significantly underrepresented. This also seems to be the case in music education for younger children. Accordingly, the relationship between music education and the ethnic diversity of the contemporary Swedish society, not reflected in the selection of students to the Swedish music and culture schools, is of vital iIn Swedish higher formal aesthetic education, students from ethnic mi-norities are significantly underrepresented. This also seems to be the case in music education for younger children. Accordingly, the relation-ship between music education and the ethnic diversity of the contem-porary Swedish society, not reflected in the selection of students to the Swedish music and culture schools, is of vita
